Itraconazole

Manufactured by Santa Cruz Biotechnology

Sourced in United States

Itraconazole is a laboratory product manufactured by Santa Cruz Biotechnology. It is an antifungal medication used in research applications.

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Lab products found in correlation

Voriconazole, by Santa Cruz Biotechnology (2 mentions) Dipyridamole, by Merck Group (2 mentions) Fluconazole and voriconazole, by Pfizer (2 mentions) Guanidine hydrochloride, by Merck Group (2 mentions) Ketoconazole, by Enzo Life Sciences (2 mentions) Sant 1, by Bio-Techne (2 mentions) Sant 2, by Bio-Techne (2 mentions) β estradiol, by Merck Group (2 mentions) Posaconazole, by Merck Group (2 mentions) Ketoconazole, by Santa Cruz Biotechnology (1 mentions) Posaconazole, by Santa Cruz Biotechnology (1 mentions) Isavuconazole, by Merck Group (1 mentions) Fluconazole, by ICN Biomedicals (1 mentions) Ni2 nitrilotriacetate nta agarose, by Qiagen (1 mentions) Posaconazole, by Selleck Chemicals (1 mentions) Potato dextrose agar (pda), by Thermo Fisher Scientific (1 mentions) Amphotericin b, by Avantor (1 mentions) Dimethyl sulfoxide (dmso), by Merck Group (1 mentions) Amphotericin b, by Merck Group (1 mentions) Rpmi 1640 medium, by Merck Group (1 mentions)

5 protocols using itraconazole

Synthesis and Characterization of Novel Antifungal Compounds

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Large preparations of VNI, FF-VNI, VFV, and F-VFV were synthesized by the Chemical Synthesis Core Facility (Vanderbilt Institute of Chemical Biology),^{34 (link)} and synthesis of their analogues CF₃F-VNI and VFV-Cl has been described previously.^{9 (link),10 (link)} The purity of the compounds was >95%. Voriconazole, ketoconazole, itraconazole, and posaconazole were purchased from Santa Cruz Biotechnology (Dallas, TX); isavuconazole was from Sigma-Aldrich, and fluconazole was from ICN Biomedicals. Hydroxypropyl-β-cyclodextrin (HPCD) was purchased from Cyclodextrin Technology Development (Gainesville, FL). DEAE- and CM-Sepharose resins were from GE Healthcare, and Ni²⁺-nitrilotriacetate (NTA) agarose was purchased from Qiagen.

Hargrove T.Y., Wawrzak Z., Rachakonda G., Nes W.D., Villalta F., Guengerich F.P, & Lepesheva G.I. (2021). Relaxed Substrate Requirements of Sterol 14α-Demethylase from Naegleria fowleri Are Accompanied by Resistance to Inhibition. Journal of medicinal chemistry, 64(23), 17511-17522.

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Compound Procurement and Preparation for Biological Experiments

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The following compounds were purchased: itraconazole (Santa Cruz Biotechnology); posaconazole (Merck); ketoconazole (Enzo Life Sciences); fluconazole and voriconazole (Pfizer); T-00127-HEV1 (Pharmeks Ltd.); dipyridamole, guanidine hydrochloride (GuHCl) and β-estradiol (Sigma Aldrich); Sant-1, Sant-2 (Tocris Bioscience); cyclopamine-KAAD (Calbiochem). PIK93 was a kind gift from Dr. K. Shokat, UC Berkeley, USA, BF738735 (MacLeod et al., 2013 (link)) was provided by Galapagos NV, Mechelen, Belgium, and OSW-1 was isolated from nature (Burgett et al., 2011 (link)). β-estradiol was dissolved according to the manufacturer’s instructions, GuHCl was dissolved in water and all other compounds in DMSO.

Strating J.R., van der Linden L., Albulescu L., Bigay J., Arita M., Delang L., Leyssen P., van der Schaar H.M., Lanke K.H., Thibaut H.J., Ulferts R., Drin G., Schlinck N., Wubbolts R.W., Sever N., Head S.A., Liu J.O., Beachy P.A., De Matteis M.A., Shair M.D., Olkkonen V.M., Neyts J, & van Kuppeveld F.J. (2015). Itraconazole Inhibits Enterovirus Replication by Targeting the Oxysterol-Binding Protein. Cell Reports, 10(4), 600-615.

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Antifungal Susceptibility of Blastomyces

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Clinical isolates of Blastomyces spp collected at the University of Wisconsin Hospital between 2004 and 2017 were tested for antifungal susceptibility retrospectively. They were cultured at 35°C for 10–15 days on potato dextrose agar (Oxoid, Hampshire, England) to induce conidial formation. Conidia were then suspended in Roswell Park Memorial Institute (RPMI) 1640 medium (Sigma-Aldrich, St. Louis, MO) at 1.0 × 10⁵ conidia/mL and 200 µL was added to 96-well plates containing the antifungals. Five antifungals were tested: itraconazole, voriconazole, and isavuconazole (Santa Cruz Biotechnology, Santa Cruz, CA), posaconazole (Selleck Chemicals, Houston, TX), and amphotericin B (AMRESCO, Solon, OH). Stock solutions were prepared in dimethyl sulfoxide (Sigma-Aldrich) except for amphotericin B, which was in sterile water. Drugs were diluted into RPMI medium via serial doubling dilutions, with concentrations ranging from 0.015 to 8.0 µg/mL except for itraconazole, which had concentrations ranging from 0.13 to 64 µg/mL.

Scolarici M.J., King C., Sterkel A., Smith J., Gauthier G, & Saddler C. (2022). The Role of Isavuconazonium Sulphate for the Treatment of Blastomycosis: A Case Series and Antifungal Susceptibility. Open Forum Infectious Diseases, 9(7), ofac220.

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Azole Resistance Profiling in Aspergillus

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TR₃₄ and TR₄₆ repeat analysis within cyp51A was performed using qPCR as described [36 (link)], additional information about the sequence of the cyp51A was available for human isolates (Additional file 1: Table S1). Microdilution assays to determine Minimum inhibitory concentrations (MIC) of itraconazole (Santa Cruz Biotech, Dallas, USA), posaconazole (MSD, Kenilworth, USA) and voriconazole (Pfizer, New York, USA) were performed according to EUCAST (http://www.eucast.org/fileadmin/src/media/PDFs/EUCAST_files/AFST/Files/EUCAST_E_Def_9_3_Mould_testing_definitive.pdf).

Valdes I.D., van den Berg J., Haagsman A., Escobar N., Meis J.F., Hagen F., Haas P.J., Houbraken J., Wösten H.A, & de Cock H. (2018). Comparative genotyping and phenotyping of Aspergillus fumigatus isolates from humans, dogs and the environment. BMC Microbiology, 18, 118.

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Compound Sources and Preparation for Biological Assays

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The following compounds were purchased: itraconazole (Santa Cruz Biotechnology); posaconazole (Merck); ketoconazole (Enzo Life Sciences); fluconazole and voriconazole (Pfizer); T-00127-HEV1 (Pharmeks); dipyridamole, guanidine hydrochloride (GuHCl), and β-estradiol (Sigma Aldrich); Sant-1, Sant-2 (Tocris Bioscience); and cyclopamine-KAAD (Calbiochem). PIK93 was a kind gift from Dr. K. Shokat (Universeity of California, Berkeley), BF738735 (MacLeod et al., 2013 (link)) was provided by Galapagos NV, and OSW-1 was isolated from nature (Burgett et al., 2011 (link)). β-estradiol was dissolved according to the manufacturer’s instructions. GuHCl was dissolved in water and all other compounds in DMSO.

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