SST was purchased from Bachem. The following chemicals were products of R&D Systems: tetrodotoxin (TTX), kynurenic acid, picrotoxin, CGP55845, BAPTA, SCH23390, linopirdine, ZD7288, CH275, L-803,087, BIM 23052, 1R,1′S,3′R/1R,1′R,3′S)-L-054,264 (abbreviated as L-054,264), octreotide, CYN154806, GDP-β-S, MDL12330A, SQ22536, Rp-cAMPS, H89, KT5720, GF109203X, forskolin, IBMX, HJC0350. PKI(5-24) was provided by Enzo Life Sciences. Drugs were initially prepared in stock solution, aliquoted and stored at −20°C. For those chemicals which are only soluble in dimethyl sulfoxide (DMSO), the concentration of DMSO was less than 0.1%. This concentration of DMSO either in the recording pipettes or in the bath had no significant effects on neuronal activity.
Kt5720
Manufactured by R&D Systems
Sourced in Macao
KT5720 is a potent and selective inhibitor of cAMP-dependent protein kinase (PKA). It acts by competitively blocking the ATP-binding site of the kinase, thereby inhibiting its activity.
Automatically generated - may contain errors
Lab products found in correlation
Forskolin, by R&D Systems (2 mentions)
Gf109203x, by R&D Systems (2 mentions)
Picrotoxin, by R&D Systems (1 mentions)
Gdp β s, by R&D Systems (1 mentions)
Sq22536, by R&D Systems (1 mentions)
3 isobutyl 1 methyl xanthine (ibmx), by R&D Systems (1 mentions)
Bapta, by R&D Systems (1 mentions)
Sch23390, by R&D Systems (1 mentions)
Kynurenic acid, by R&D Systems (1 mentions)
Cgp 55845, by R&D Systems (1 mentions)
Tetrodotoxin, by R&D Systems (1 mentions)
Zd7288, by R&D Systems (1 mentions)
Gallein, by R&D Systems (1 mentions)
Nifedipine, by R&D Systems (1 mentions)
Sp600125, by R&D Systems (1 mentions)
U0126, by R&D Systems (1 mentions)
ω conotoxin mviic, by Bio-Techne (1 mentions)
Ly294002, by R&D Systems (1 mentions)
Sb203580, by R&D Systems (1 mentions)
Phorbol myristate acetate (pma), by Bio-Techne (1 mentions)
2 protocols using kt5720
1
Neurophysiological Recordings with Diverse Pharmacological Agents
2
Pharmacological Modulation of Ion Currents
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All drugs were purchased from Sigma (MO, USA) unless otherwise indicated. Stock solutions of 4-aminopyridine (4-AP), pertussis toxin (PTX), cholera toxin (CTX), PMA (Tocris Bioscience, Ellisville, MO) and ω-conotoxin MVIIC (Tocris Bioscience, Ellisville, MO) were prepared in distilled deionized water. Z941 was a kind gift from Dr. Terrance P. Snutch (University of British Columbia, Vancouver, British Columbia, Canada). Stock solutions of cholecystokinin-8 (Tocris Bioscience, Ellisville, MO), LY294002, CCK-4, nifedipine, forskolin, gallein, wortmannin, KT5720 (RD system), devazepide, LY225910, GW5823, BC264, SP600125, SB203580, anisomycin, PP2, PP3, Akt inhibitor III, U0126, and GF109203X were prepared in dimethylsulfoxide (DMSO). The final concentration of DMSO in the bath solution was estimated to be less than 0.01%, and this compound had no functional effects on IA (not shown).
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