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Cb 839

Manufactured by Aurogene
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CB-839 is a small molecule inhibitor. It targets the enzyme glutaminase, which is involved in cellular metabolism.

Automatically generated - may contain errors

Lab products found in correlation

Etomoxir, by Merck Group (2 mentions) Physcion, by Merck Group (2 mentions) 2 3 butanedione 2 monoxime bdm, by Merck Group (2 mentions)

2 protocols using cb 839

1

Zebrafish Cardiac Contractility Modulation

Check if the same lab product or an alternative is used in the 5 most similar protocols
For the vMCs coverage analysis, zebrafish embryos were treated with the following drugs: 6-AN (Sigma), Physcion (Sigma), CB-839 (Aurogene #S-7655), Etomoxir (Sigma) and AZ67 (TOCRIS #5742) from 48 hpf (hours post fertilization) onward. The myosin ATPase inhibitor 2,3-butanedione 2-monoxime (BDM) (Sigma) was used to block cardiac contraction in the developing embryo as previously published. BDM was dissolved at 4 mM in fish water embryo media and added after the establishing of the embryonic circulation at 30 hpf until 3 dpf (days post fertilization). R5P was injected at 500 mM in once cell stage zebrafish embryos.
Facchinello N., Astone M., Audano M., Oberkersch R.E., Spizzotin M., Calura E., Marques M., Crisan M., Mitro N, & Santoro M.M. (2022). Oxidative Pentose Phosphate Pathway Controls Vascular Mural Cell Coverage by Regulating Extracellular Matrix Composition. Nature metabolism, 4(1), 123-140.
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2

Zebrafish Cardiac Contractility Modulation

Check if the same lab product or an alternative is used in the 5 most similar protocols
For the vMCs coverage analysis, zebrafish embryos were treated with the following drugs: 6-AN (Sigma), Physcion (Sigma), CB-839 (Aurogene #S-7655), Etomoxir (Sigma) and AZ67 (TOCRIS #5742) from 48 hpf (hours post fertilization) onward. The myosin ATPase inhibitor 2,3-butanedione 2-monoxime (BDM) (Sigma) was used to block cardiac contraction in the developing embryo as previously published. BDM was dissolved at 4 mM in fish water embryo media and added after the establishing of the embryonic circulation at 30 hpf until 3 dpf (days post fertilization). R5P was injected at 500 mM in once cell stage zebrafish embryos.
Facchinello N., Astone M., Audano M., Oberkersch R.E., Spizzotin M., Calura E., Marques M., Crisan M., Mitro N, & Santoro M.M. (2022). Oxidative Pentose Phosphate Pathway Controls Vascular Mural Cell Coverage by Regulating Extracellular Matrix Composition. Nature metabolism, 4(1), 123-140.
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