Anti c cbl 2747

Manufactured by Cell Signaling Technology

Anti-c-Cbl (2747) is a primary antibody that recognizes the c-Cbl protein. c-Cbl is an E3 ubiquitin-protein ligase that plays a role in the regulation of signal transduction pathways.

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Lab products found in correlation

Mg132, by Merck Group (1 mentions) Pierce silver stain kit, by Thermo Fisher Scientific (1 mentions) Control shrna lentiviral particles sc 108080, by Santa Cruz Biotechnology (1 mentions) Anti ubiquitin sc 8017, by Santa Cruz Biotechnology (1 mentions) Alexa fluor conjugated phalloidin, by Thermo Fisher Scientific (1 mentions) P selectin, by R&D Systems (1 mentions) Sdf 1α, by R&D Systems (1 mentions) Czc24832, by Merck Group (1 mentions) Latrunculin b, by Merck Group (1 mentions) S nitro blebbistatin, by Cayman Chemical (1 mentions) Recombinant mouse icam 1 fc, by R&D Systems (1 mentions) Anti cd3 clone 2c11, by BioXCell (1 mentions) Anti cd28 clone pv 1, by BioXCell (1 mentions) Sti571, by Merck Group (1 mentions)

Spelling variants of this product

C-Cbl (8 citations) Anti-c-Cbl (5 citations) Anti-Cbl (2 citations)

2 protocols using anti c cbl 2747

Molecular Mechanisms of DSG1 Regulation

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DSG1 and HA-tagged S100A4, CYP11A1, ACSS1, LY6G6D, NR5A1, AIF1L, and FAM167A were cloned into the MigR1 vector. pClneo-Myc-Erbin was obtained from Addgene. pFLAG-NIK-DN was described previously [30 (link)]. Anti-FAM167A (sc-393999), anti-glyceraldehyde 3-phosphate dehydrogenase (GAPDH) (sc-166574), anti-p100/p52 (sc-7386 X), anti-DSG1 (sc-59904), and anti-ubiquitin (sc-8017) antibodies were purchased from Santa Cruz Biotechnology; anti-NIK (4994), anti-p100/p52 (4882), anti-Myc (2276), anti-TRAF3 (4729), anti-CHIP (2080), and anti-c-cbl (2747) antibodies were purchased from Cell Signaling Technology; the anti-DSG1 antibody (32–6000) was purchased from Invitrogen; the anti-Erbin antibody (NBP2–13968) was purchased from Novus Biologicals; and the control IgG (H9658) was purchased from Sigma-Aldrich. Imatinib (sc-202180). DSG1-specific short hairpin RNA (shRNA) lentiviral particles (sc-35224-V) and control shRNA lentiviral particles (sc-108080) were obtained from Santa Cruz Biotechnology. Nilotinib (1750) was obtained from BioVision, recombinant FAM167A (MBS1363522) was obtained from MyBioSource, SN50 (481480) and MG132 (474790) were obtained from Sigma-Aldrich, and the Pierce Silver Stain Kit (24612) was obtained from Thermo Fisher Scientific.

Yang T., Sim K.Y., Ko G.H., Ahn J.S., Kim H.J, & Park S.G. (2022). FAM167A is a key molecule to induce BCR-ABL-independent TKI resistance in CML via noncanonical NF-κB signaling activation. Journal of Experimental & Clinical Cancer Research : CR, 41, 82.

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Immune Cell Activation Pathway Profiling

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Anti-CD3 clone 2C-11, anti-CD28 clone PV1, and LFA-1 blocking anti-CD11a clone M17/4 were obtained from BioXCell. Anti-pTyr clone PY-20 and anti-p85 (ABS234) was from Upsate (Millipore). Anti-HEF1 (CasL) clone 2G9 and anti-Pyk2 clone YE353 were obtained from Abcam. Anti-Rac1 (610650) and anti-AKT (559028) were from BD. Anti-pAKT (4051), anti-pERK (9101), and anti-c-Cbl (2747) were from Cell Signaling. Anti-Cdc42 (SC-87), anti-CrkL (SC-319), and anti-Cbl-b (SC-8006) were from Santa Cruz. Secondary antibodies conjugated to appropriate fluorophores were obtained from Molecular Probes and Jackson Immunoresearch. AlexaFluor-conjugated phalloidin was purchased from Molecular Probes. Recombinant mouse ICAM-1-Fc, SDF-1α, and P-selectin were purchased from R&D Systems. The ROCK inhibitor Y-27632, the pan PI3K inhibitor LY-294002, and the PI3Kδ inhibitor IC87114 were obtained from CalBiochem. The myosin inhibitor (s)-nitro-blebbistatin was purchased from Cayman Chemicals. The actin destabilizing drug latrunculin B, the Src inhibitor PP2, the Abl kinase inhibitor STI-571, and the PI3Kγ inhibitor CZC24832 were purchased from Sigma.

Roy N.H., MacKay J.L., Robertson T.F., Hammer D.A, & Burkhardt J.K. (2018). Crk adaptor proteins mediate actin-dependent T cell migration and mechanosensing induced by the integrin LFA-1. Science signaling, 11(560), eaat3178.

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