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Finepointe system

Manufactured by Buxco Electronics
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Sourced in United States

The FinePointe system is a comprehensive suite of modular hardware and software components designed for conducting physiological measurements. It provides a versatile platform for researchers to configure and customize their experimental setup based on specific requirements.

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Lab products found in correlation

Methacholine chloride, by Merck Group (1 mentions) Ketamine hydrochloride, by Merck Group (1 mentions) Xylazine hydrochloride, by Merck Group (1 mentions) Methacholine, by Merck Group (1 mentions) Methacholine, by Buxco Electronics (1 mentions) Unrestrained whole body plethysmography, by Buxco Electronics (1 mentions)

7 protocols using finepointe system

1

Measuring Airway Hyperreactivity to Methacholine

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Airway Hyperreactivity was measured after inhalation of increasing concentrations of methacholine (5–40 mg/mL) and determination of airway resistance (RI) by invasive plethysmography using the FinePointe system (Buxco, DSI) after each concentration of methacholine, as previously described (25 (link)).
Michaudel C., Maillet I., Fauconnier L., Quesniaux V., Chung K.F., Wiegman C., Peter D, & Ryffel B. (2018). Interleukin-1α Mediates Ozone-Induced Myeloid Differentiation Factor-88-Dependent Epithelial Tissue Injury and Inflammation. Frontiers in Immunology, 9, 916.
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2

Airway Hyperresponsiveness Measurement

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Airway hyperresponsiveness was measured by using increasing concentrations of methacholine (25–200 mg/mL) using the FinePointe system (Buxco, DSI) as previously described (43 (link)).
Michaudel C., Bataille F., Maillet I., Fauconnier L., Colas C., Sokol H., Straube M., Couturier-Maillard A., Dumoutier L., van Snick J., Quesniaux V.F., Togbe D, & Ryffel B. (2020). Ozone-Induced Aryl Hydrocarbon Receptor Activation Controls Lung Inflammation via Interleukin-22 Modulation. Frontiers in Immunology, 11, 144.
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3

Airway Responsiveness in OVA-Treated Mice

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Airway responsiveness in the OVA-treated mice was measured 24 h after the last OVA intratracheal instillation using whole body plethysmography (WBP) in a noninvasive fashion (Buxco FinePointe System, Buxco, Wilmington, USA) according to the manufacturer’s instructions (5–6 animals per group). Mice were given 5 min for acclimation and then exposed to nebulized PBS to set a baseline value, followed by increasing concentrations of 50 μL nebulized methacholine chloride (Sigma-Aldrich, German; 3.125, 6.25, 12.5, 25, and 50 mg/mL in PBS) for 2 min. Airway responsiveness to methacholine was monitored continuously for 3 min following methacholine inhalation and then evaluated using the enhanced pause (Penh) values and respiratory frequency (f).
Yanagisawa R., Koike E., Win-Shwe T.T, & Takano H. (2019). Oral exposure to low dose bisphenol A aggravates allergic airway inflammation in mice. Toxicology Reports, 6, 1253-1262.
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4

Airway Hyperresponsiveness Measurement

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Airway hyperresponsiveness was measured by using increasing concentrations of methacholine (25–200 mg/mL) using the FinePointe system (Buxco, DSI) as previously described16 (link).
Michaudel C., Fauconnier L., Julé Y, & Ryffel B. (2018). Functional and morphological differences of the lung upon acute and chronic ozone exposure in mice. Scientific Reports, 8, 10611.
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5

Measuring Airway Hyperresponsiveness in Mice

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Invasive analysis of lung function was performed for mice anesthetized with ketamine hydrochloride (0.08 µg/g; Sigma-Aldrich) and xylazine hydrochloride (0.008 µg/g; Sigma-Aldrich) in 0.9% NaCl. A steel cannula was inserted into the trachea, after which the mouse was placed in a chamber to measure lung resistance (RL) with exposure to increasing doses of methacholine using a FinePointe system (Buxco Electronics, Inc., Wilmington, NC, USA). AHR was assessed by noninvasive measurement of dynamic airway resistance (Penh value) with increasing aerosol concentrations of acetyl-β-methylcholine chloride (methacholine; Sigma-Aldrich) using unrestrained whole body plethysmography (Buxco).
Lin I.P., Hsu Y.S., Kang S.W., Hsieh M.H, & Wang J.Y. (2014). Escherichia coli Heat-Labile Detoxified Enterotoxin Modulates Dendritic Cell Function and Attenuates Allergic Airway Inflammation. PLoS ONE, 9(3), e90293.
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6

Mouse Lung Dynamic Compliance Measurement

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Mouse lung dynamic compliance (Cdyn) was recorded using a FinePointe system (Buxco, St. Paul, MN) as previously described [30 (link), 35 (link)].
Xie Y., Jiang H., Zhang Q., Mehrotra S., Abel P.W., Toews M.L., Wolff D.W., Rennard S., Panettieri RA J.r., Casale T.B, & Tu Y. (2016). Upregulation of RGS2: a new mechanism for pirfenidone amelioration of pulmonary fibrosis. Respiratory Research, 17(1), 103.
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7

Citric Acid-Induced Cough Response

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One hour following the end of vehicle or drug administration on Day 15, the animals were placed into a whole-body plethysmograph connected to a Buxco Finepointe system. Animals were then exposed to nebulized 400 mM citric acid for 7 minutes. Cough counts were recorded throughout the 7 minute exposure period and for 10 minutes following the end of nebulization period. Animals were euthanized within approximately 60 min following the end of the cough challenge recording period by an overdose of pentobarbitone administered by the intraperitoneal route.
Tochitsky I., Jo S., Andrews N., Kotoda M., Doyle B., Shim J., Talbot S., Roberson D., Lee J., Haste L., Jordan S.M., Levy B.D., Bean B.P, & Woolf C.J. (2021). Inhibition of inflammatory pain and cough by a novel charged sodium channel blocker. British journal of pharmacology, 178(19), 3905-3923.
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