Immunostaining of all brain sections were carried out by University of California-Irvine, Pathology services using Ventana BenchMark Ultra protocols. Neighboring slices were immunostained for Ubiquitin (Cell Marque catalog no. 318A-18, Rocklin, CA, USA) and α-synuclein (EMD Millipore Corporation, lot No. 2985418, Burlington, MA, USA). All IHC stained slides were scanned using the Ventana Roche instrumentation and analyzed using QuPath. Adjacent slices were also immunostained for Aβ plaques and total Tau. All IHC stained slides were scanned using the Ventana Roche instrumentation and analyzed using QuPath [29 (link)].
Ubiquitin
Manufactured by Cell Marque
Sourced in United States
Ubiquitin is a small, highly conserved protein that is found in all eukaryotic cells. Its core function is to tag other proteins for degradation by the proteasome, a process known as ubiquitination. This tagging process plays a crucial role in the regulation of various cellular processes, including cell signaling, cell cycle control, and protein quality control.
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Lab products found in correlation
2 protocols using ubiquitin
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Immunostaining of Brain Sections
2
Brain Immunostaining for Protein Analysis
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Immunostaining of all brain sections were carried out by University of California-Irvine, Pathology services using Ventana BenchMark Ultra protocols. Neighboring slices were immunostained for Ubiquitin (Cell Marque catalog no. 318A-18, Rocklin, CA, USA) and α-synuclein (EMD Millipore Corporation, lot No. 2985418, Burlington, MA, USA). All IHC stained slides were scanned using the Ventana Roche instrumentation and analyzed using QuPath.
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