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Hydroxypropyl methyl cellulose e5 hpmc e5

Manufactured by Dow
Sourced in United States

Hydroxypropyl methyl cellulose E5 (HPMC E5) is a cellulose-based polymer used as a laboratory and pharmaceutical excipient. It is a non-ionic, water-soluble, and thermoplastic material. HPMC E5 is used to modify the viscosity, stability, and other physical properties of aqueous solutions and dispersions.

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2 protocols using hydroxypropyl methyl cellulose e5 hpmc e5

1

EFdA and CSIC Synthesis and Characterization

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Custom synthesis of EFdA was carried out by Life Chemicals (Burlington, ON, Canada) and CSIC was synthesized by Dalton Laboratories (Toronto, ON, Canada). The drugs were >95% pure as assessed by HPLC/MS and NMR according to the suppliers. DMSO, McCoy’s 5A medium and fetal bovine serum (FBS) were obtained from Fisher Scientific (Pittsburgh, PA, US). PBS (pH 7.4) and penicillin-streptomycin were purchased from Mediatech Inc (Manassas, VA, US). Polyvinyl alcohol (PVA), Pullulan, (2-hydroxypropyl)-β-cyclodextrin (HP-β-CD), glycerin and PEG 400 were purchased from Spectrum (Gardena, CA, US). PEG 4000 and hydroxypropyl methyl cellulose E5 (HPMC E5) were obtained from Dow Chemical Company (Midland, MI, US). MTT, cremophor RH 40, bovine serum albumin (BSA) and methyl-β-cyclodextrin (M-β-CD) were purchased from Sigma-Aldrich (St. Louis, MO, USA). Pluronic F127 was kindly provided by BASF Ltd. (NJ, US). All other chemicals were analytical grade. Ultrapure water was obtained in-house from a MilliQ water purification system.
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2

Ginkgo Biloba Compounds Extraction and Analysis

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Hydroxypropyl cellulose (HPC)-SL was obtained from Japan Caoda Co. Ltd (Hong Kong, China). Hydroxypropyl methylcellulose E5 (HPMC E5) was purchased from Dow Chemical Company (Michigan, USA). Kolliphor HS 15, Poloxamer 188 and Polyvinylpyrrolidone K30 (PVP K30) were generously provided by BASF (China) Ltd. (Shanghai, China). Sodium dodecyl sulfate (SDS) was purchased from Hunan Erkang Pharmaceutical Co. Ltd. (Changsha, China). Ginkgolide A (GA ≥ 95%), ginkgolide B (GB ≥ 95%), ginkgolide C (GC ≥ 95%), ginkgolide J (GJ ≥ 95%), bilobalide (BB ≥ 98%), quercetin (QCT ≥ 98%), isorhamnetin (ISR ≥98%), kaempferol (KMF ≥ 98%) were purchased from National Institutes for Food and Drug Control (Beijing, China). Acetonitrile (HPLC grade), formic acid (MS grade), trifluoroacetic acid (HPLC grade), tetrahydrofuran (HPLC grade) and methanol (HPLC grade) were acquired from Merck (Darmstadt, Germany).
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