Discovery dsc 25

DSC analysis was performed to determine the T_m and T_g of NFD, EFZ and HPMCAS. DSC studies were carried out using Discovery DSC 25 (TA Instruments DSC, New Castle, DE, USA), coupled with a RCS90 cooling device. The instrument was calibrated for temperature and heat capacity using indium and sapphire standard. All samples weighed approximately 5-10 mg and were sealed in an aluminum pan. The samples were equilibrated under nitrogen gas for one minute at 25 °C and then heated at a rate of 10 °C/min under an inert nitrogen purge of 50 mL/min. The thermograms were analyzed to detect the melting temperature and T_g.

The thermal properties of the solid component systems were determined using a DSC instrument (Discovery DSC25, TA Instruments, Newcastle, Delaware, USA) equipped with an RCS90 refrigerator cooling system. Approximately 6-8 mg of sample was sealed in an aluminum pan and heated from 25°C to 200°C at a heating rate of 10°C/min with a nitrogen purge flow rate of 50 mL/min. The empty aluminum pan was used as a reference during the measurement.
To understand the thermal events and to identify the formation of eutectics, the binary PM of ARP with the coformer (NA) was prepared at different molar ratios (1:1, 1:2, 1:3, 2:1 and 3:1) [22 (link)]. The mixtures were heated in sealed DSC pans from 25°C to 200°C at a heating rate of 10°C/min. The melting onset of the endothermic peak is considered the solidus, and the peak melting temperature (endpoint) of the DSC endothermic peak is referred to as the liquidus [23 (link),24 ].