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B6 cg thy1a cy tg tcratcrb 8rest j pmel

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This mouse strain carries a transgene that expresses a T cell receptor specific for the melanoma antigen pmel-17. The transgene is expressed on a C57BL/6 background with the Thy1.1 allele. This strain is commonly used in studies of immune responses to melanoma.

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Lab products found in correlation

Hif1af f mice, by Jackson ImmunoResearch (2 mentions) Sj l thy1.1, by Jackson ImmunoResearch (2 mentions) Tg tcratcrb 1100mjb j ot 1, by Jackson ImmunoResearch (2 mentions) Cd4 cre, by Jackson ImmunoResearch (2 mentions) C57bl 6, by Jackson ImmunoResearch (2 mentions) Nod scid mice, by Charles River Laboratories (1 mentions) C57bl 6 mice, by Charles River Laboratories (1 mentions) C57bl 6j mice, by Jackson ImmunoResearch (1 mentions)

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B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest/J (27 citations) B6.Cg Thy1a-Tg(TcraTcrb)8Rest/J (4 citations) B6.Cg-Thy1a/Cy Tg (TcraTcrb)8Rest/J (Pmel-1) (3 citations) B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest) (2 citations) B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest/J (Pmel) mice (2 citations) Pmel-1/Thy1.1 mice (B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest/J), (2 citations)

4 protocols using b6 cg thy1a cy tg tcratcrb 8rest j pmel

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Mouse Models for Immunotherapy Research

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Mouse experiments were approved by the Institutional Animal Care and Use Committee (IACUC) of The Wistar Institute. C57BL/6 mice (female, 6–8 weeks old) and NOD-SCID mice (female, 6-8 weeks old) were purchased from Charles River. B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest/J (PMEL, female, 6–8 weeks old) mice were purchased from the Jackson Laboratory.
Hashimoto A., Sarker D., Reebye V., Jarvis S., Sodergren M.H., Kossenkov A., Sanseviero E., Raulf N., Vasara J., Andrikakou P., Meyer T., Huang K.W., Plummer R., Chee C.E., Spalding D., Pai M., Khan S., Pinato D.J., Sharma R., Basu B., Palmer D., Ma Y.T., Evans J., Habib R., Martirosyan A., Elasri N., Reynaud A., Rossi J.J., Cobbold M., Habib N.A, & Gabrilovich D.I. (2021). Upregulation of C/EBPα Inhibits Suppressive Activity of Myeloid Cells and Potentiates Antitumor Response in Mice and Patients with Cancer. Clinical Cancer Research, 27(21), 5961-5978.
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Preclinical Murine Model for Melanoma

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C57BL/6J mice (Stock No. 000664) and B6.Cg-Thy1 a/Cy Tg(TcraTcrb)8Rest/J (PMEL; Stock No. 005023 (32 (link))) were purchased from the Jackson Laboratory and housed in animal facility of the UPMC Children’s Hospital of Pittsburgh. Animals were kept in the facility for at least one week prior to performing any procedures to minimize stress-related symptoms. 5–6-week-old female were used in the experiments. All experiments were conducted following protocols approved by the University of Pittsburgh Institutional Animal Care and Use Committee (IACUC).
Raphael I., Kumar R., McCarl L.H., Shoger K., Wang L., Sandlesh P., Sneiderman C.T., Allen J., Zhai S., Campagna M.L., Foster A., Bruno T.C., Agnihotri S., Hu B., Castro B.A., Lieberman F.S., Broniscer A., Diaz A.A., Amankulor N.M., Rajasundaram D., Pollack I.F, & Kohanbash G. (2021). TIGIT and PD-1 Immune Checkpoint Pathways Are Associated With Patient Outcome and Anti-Tumor Immunity in Glioblastoma. Frontiers in Immunology, 12, 637146.
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Murine Model Immunology Protocols

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Animal work was done in accordance with the Institutional Animal Care and Use Committee of the University of Pittsburgh. All mice were on C57BL/6 background, used at 6–8 weeks of age, were both male and female, and housed in specific pathogen free conditions prior to use. C57BL/6, SJ/L (Thy1.1), Cd4Cre, Tg(TcraTcrb)1100Mjb/J (OT-I), B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest/J (Pmel), and HIF1af/f mice were obtained from The Jackson Laboratory. Prdm1f/f mice were a gift from A. Poholek (University of Pittsburgh). E8I-CreERT2 GFP x Rosa26-LSL-TdTomato mice and spleens from Tg(Nr4a1-EGFP/cre)820Khog/J (Nur77-GFP reporter) mice were a gift from D.A.A. Vignali (University of Pittsburgh).
Scharping N.E., Rivadeneira D.B., Menk A.V., Vignali P.D., Ford B.R., Rittenhouse N.L., Peralta R., Wang Y., Wang Y., DePeaux K., Poholek A.C, & Delgoffe G.M. (2021). Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion. Nature immunology, 22(2), 205-215.
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4

Murine Model Immunology Protocols

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Animal work was done in accordance with the Institutional Animal Care and Use Committee of the University of Pittsburgh. All mice were on C57BL/6 background, used at 6–8 weeks of age, were both male and female, and housed in specific pathogen free conditions prior to use. C57BL/6, SJ/L (Thy1.1), Cd4Cre, Tg(TcraTcrb)1100Mjb/J (OT-I), B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest/J (Pmel), and HIF1af/f mice were obtained from The Jackson Laboratory. Prdm1f/f mice were a gift from A. Poholek (University of Pittsburgh). E8I-CreERT2 GFP x Rosa26-LSL-TdTomato mice and spleens from Tg(Nr4a1-EGFP/cre)820Khog/J (Nur77-GFP reporter) mice were a gift from D.A.A. Vignali (University of Pittsburgh).
Scharping N.E., Rivadeneira D.B., Menk A.V., Vignali P.D., Ford B.R., Rittenhouse N.L., Peralta R., Wang Y., Wang Y., DePeaux K., Poholek A.C, & Delgoffe G.M. (2021). Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion. Nature immunology, 22(2), 205-215.
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