Hiv ag ab combo

Manufactured by Abbott

Sourced in United States

The HIV Ag/Ab Combo is a laboratory diagnostic test used to detect the presence of antibodies to HIV-1 and HIV-2, as well as the HIV-1 p24 antigen. It is designed to provide a comprehensive assessment of HIV infection status.

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Lab products found in correlation

Anti hbc 2, by Abbott (1 mentions) Hbsag, by Abbott (1 mentions) Anti hbs, by Abbott (1 mentions) Architect i2000 system, by Abbott (1 mentions) Anti hcv, by Abbott (1 mentions) Architech i2000, by Abbott (1 mentions) Inno lia hiv 1 2 score, by Fujirebio (1 mentions) Vca igg, by DiaSorin (1 mentions) Cmia sars cov 2 igg assay, by Abbott (1 mentions) Elecsys hiv combi pt, by Roche (1 mentions) Anti hbc, by Abbott (1 mentions) Cobas 6800 system, by Roche (1 mentions)

5 protocols using hiv ag ab combo

Blood Donor Screening for Transfusion-Transmissible Infections

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All the collected blood units were screened for TTIs in accordance with national donor screening guidelines. For serological testing, the automated chemiluminescent microparticle immunoassay analyzer ARCHITECT i2000 system (CMIA, Abbott Diagnostic, USA), with validated commercially available assays, was used for the detection of HBsAg (ARCHITECT HBsAg Qualitative), Anti-HCV (ARCHITECT Anti-HCV), HIV p24 antigen and anti-HIV-1&2 (ARCHITECT HIV Ag/Ab Combo), anti-HBc (ARCHITECT Anti-HBc II), and Anti-HBs (ARCHITECT Anti-HBs). All procedures were carried out according to the manufacturer's instruction, and the results were expressed as a signal to cut-off (S/CO), and S/CO > 1.0 was considered reactive. In addition to CMIA, blood units were also tested in parallel by individual nucleic acid test (ID-NAT) for HBV-DNA, HCV-RNA and HIV-1&2-RNA using The Procleix Ultrio Elite assay on the Panther system (Grifols, Spain) as indicated by the manufacturer's instructions. For initially reactive samples, the Ultrio Elite discriminatory assays for HIV-1/2, HCV, or HBV were performed.

Mobarki A.A., Madkhali M.M., Dobie G., Saboor M., Madkhali A.M., Madkhli B., Hummadi Y., Meshi A., Al-Mekhlafi H.M., Akhter M.S, & Hamali H.A. (2022). Patterns of Hepatitis B, Hepatitis C and HIV Among Blood Donors in Samtah-Jazan Region. Journal of Epidemiology and Global Health, 12(3), 304-310.

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HIV Antibody Detection Protocol

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HIV antibody tests were using a chemiluminescent microparticle immunoassay (Abbott Architech i2000, Abbott Laboratories, Lake Forest, IL, USA) using the HIV Ag/Ab Combo (Abbott Laboratories, Sligo, Ireland) reagent.

Park J.W., Yang T.W., Kim Y.K., Choi B.M., Kim H.J, & Park D.W. (2014). Ten years of experience in the prevention of mother-to-child human immunodeficiency virus transmission in a university teaching hospital. Korean Journal of Pediatrics, 57(3), 117-124.

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Comprehensive Diagnostic Assays for Viral Infections

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Blood counts were determined at the Central Laboratory of the University Hospital Essen according to routine procedures. For HIV-1/2 diagnostics, the screening tests Architect HIV Ag/Ab Combo (chemiluminescent microparticle immunoassay (CMIA); Abbott, Wiesbaden, Germany) and Elecsys HIV combi PT (electrochemiluminescence immunoassay; Roche Diagnostics, Rotkreuz, Switzerland) were utilized. Further, the confirmatory test INNO-LIA HIV I/II Score (line-immunoassay; Fujirebio, Hannover, Germany) and RealTime HIV-1 m2000sp (qPCR; Abbott, Wiesbaden, Germany) were employed. The presence of an EBV infection was assessed using the chemiluminescence immunoassays (CLIAs) Liaison EBV IgM, VCA IgG, and EBNA IgG (all DiaSorin, Dietzenbach, Germany). SARS-CoV-2-specific Abs were measured using the SARS-CoV-2 S1/S2 IgG ELISA (DiaSorin) and the CLIA Liaison SARS-CoV-2 TrimericS IgG assay (DiaSorin) for spike-specific Abs (IgG S), while the CMIA SARS-CoV-2 IgG assay (Abbott) was used for nucleocapsid (N)-specific Abs (IgG N).

Elsner C., Appeltrath G.A., Konik M., Parreuter J., Broecker-Preuss M., Krawczyk A., Esser S., Sammet S, & Karsten C.B. (2023). False-Positive Screening and Confirmatory HIV Diagnostic Test in a Patient with Cured SARS-CoV-2 Infection Is Not Mediated by Env/Spike Cross-Reactive Antibodies. Viruses, 15(5), 1161.

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Serological and Molecular Screening for Viral Infections

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Serological examinations for Human immunodeficiency virus (HIV), Hepatitis B virus (HBc), Hepatitis C virus (HCV) and Treponema pallidum exposure were performed on Alinity s analyzer using following Alinity s assays: HIV Ag/Ab Combo, Anti-HBc, Anti-HCV and Syphilis reagent kit (Abbott, North Chicago, IL, USA). Direct detection of Human immunodeficiency virus, Hepatitis B virus, Hepatitis C virus in blood samples was performed on Cobas 6800 System with Roche Cobas MPX kit (Roche Diagnostics International AG, Rotkreuz, Switzerland). All assays and appliances were used according to manufacturer instructions.

Grujić J., Bujandrić N., Budakov-Obradović Z., Dolinaj V., Bogdan D., Savić N., Cabezas-Cruz A., Mijatović D., Simin V., Anđelić N, & Banović P. (2021). Demographic and Clinical Factors Associated with Reactivity of Anti-SARS-CoV-2 Antibodies in Serbian Convalescent Plasma Donors. International Journal of Environmental Research and Public Health, 19(1), 42.

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Improving HIV Testing Rates in Healthcare Settings

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During both the standard and enhanced testing phases, patients could be offered HIV testing directly by their providers, by HIV counselors responding to orders placed by providers in the EMR, or by counselors approaching patients without an order. In accordance with MMC policy, all offers were opt-in.
From September 1st, 2013 until May 17, 2014 specimens underwent third generation HIV testing (Siemens Medical Diagnostics) with reactive results confirmed by Western blot. From May 18, 2014 to March 31, 2015 specimens underwent fourth generation testing with the HIV Ag/Ab Combo (Abbott). Reactive results were confirmed by HIV 1/2 Multispot (Bio-Rad) or, for those with nonreactive or indeterminate Multispot results, by qualitative viral load (Aptima). Because the transition from third to fourth generation testing occurred while the EMR prompt was active, the prompt was suspended for re-programming. Therefore, the total study period comprised two periods of standard testing alternating with two periods of enhanced testing.
The number of HIV counselors on staff was constant throughout the study. Counselors worked weekdays from 9 a.m. to 5 p.m. and responded to EMR orders placed outside of these hours on the next business day. All counselors were bilingual in English and Spanish.

Felsen U.R., Cunningham C.O., Heo M., Futterman D.C., Weiss J.M, & Zingman B.S. (2017). An expanded HIV testing strategy leveraging the electronic medical record uncovers undiagnosed infection among hospitalized patients. Journal of acquired immune deficiency syndromes (1999), 75(1), 27-34.

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