Skyra mri

In 31 cases were performed on the 3.0T Skyra MRI (Siemens, Germany). Scan sequences included axial T1WI andT2WI, sagittal T1WI and FLAIR. T1WI employs T1_FLASH (Fast Low Angle Short) sequence, and T2WI employs T2_TSE sequence, FLAIR employs a t2_tirm_tra_dark-fluid. The parameters of above sequences were as follows: Axial and sagittal T1WI (T1_fl2d_tra,TR = 244ms, TE = 2.93ms, Flip angle = 70, Average = 2, Concatenation = 1, Distance factor = 20); Axial and sagittal T2WI (TSE, TR = 3,800ms, TE 112, Average 1, Concatenation 2, Flip angle 150, Turbo factor 19); axial FLAIR (t2_tirm_sag_dark-fluid TR = 900ms, TE = 81ms, TI = 2,500ms, Flip angle 150, Distance factor = 20, Average = 1, Concatenation = 2). For all axial images, scan thickness was 3mm, and distance factor was 20%. For all sagittal images, the implemented thickness was 3mm, and the distance factor was 15%.

Imaging data were collected on a 3T Siemens Skyra MRI at The University of Texas at Austin Biomedical Imaging Center. One to two (or three, if one of the first two images was of poor quality and timing allowed) high-resolution coronal T2-weighted structural scans were collected perpendicular to the hippocampal long-axis (TR = 13,150 ms, TE = 82 ms, 0.4 mm × 0.4 mm in-plane resolution, 1.5 mm thru-plane resolution, 60 slices). When two coronal images of acceptable quality were acquired (determined by visually inspecting images for artifacts or positioning that prevented visualization of the hippocampal structure) for a single participant, images were co-registered using ANTS (Avants et al., 2011 (link)) and averaged to boost the signal-to-noise ratio (SNR), creating a single mean coronal image. A whole-brain T1-weighted 3-D MPRAGE volume (TR = 1,900 ms, TE = 2.43 ms, flip angle = 9°, 1 mm isotropic voxels) was also collected to estimate overall intracranial volume.

Neuro MRI scans were acquired on a 3-Tesla Siemens Skyra MRI (Germany, Erlangen) with a 64-channel head and neck receive coil. High-resolution, whole-brain, anatomical scans were acquired using a 3D T1-weighted Magnetization-Prepared Rapid-Acquisition Gradient Echo sequence (MPRAGE; TR=2200 ms, TE=1.76 ms, TI=850 ms, FOV=240 mm, 256x256 matrix, spatial resolution=0.9 mm isotropic). rsfMRI connectivity was analyzed from multi-slice, T2* echo-planar BOLD sequences acquired with eyes closed (FOV=240x240 mm, matrix size=80x80, 56 slices, slice thickness=3 mm, TR/TE=1400/30 ms, 404 volumes, multi-slice factor=4, acceleration factor=2, scan duration=9 minutes).

MRI data were acquired on a 3 T Siemens Skyra MRI using a 32-channel head coil. Anatomical images were collected using a T1-weighted magnetization prepared rapid acquisition gradient echo (MP-RAGE) pulse sequence image (FOV = 256 mm; TR = 1800 ms; TE = 2.96 ms; image matrix = 256 × 256; 208 axial slices; voxel size = 1 mm isotropic). Functional images were collected with a multi-band gradient echo planar imaging sequence (TR = 1222 ms; TE = 24 ms; flip angle = 67 degrees; matrix = 64 × 64, FOV = 192 mm; multi-band factor = 2; 3 mm³ isotropic spatial resolution).

Image data were collected with a 3.0T Siemens Skyra MRI, with an 8-channel head coil for reception of radio frequency (RF) signals. The subjects wore professional anti-noise earplugs to blockout noise and used bilaterally affixed sponge pads to reduce head movement artifacts. The DTI data of each subject consisted of one non-diffusion-weighted and 64 diffusion-weighted images acquired with a b-value of 1,000 s/mm² uniformly distributed across 64 gradient directions. The parameters were as follows: sequence variant = SK\SP, slice thickness = 4 mm, repetition time (TR) = 5,000 ms, echo time (TE) = 98 ms, flip angle = 90°, acquisition matrix = 128*128, FOV = 1,344*1,344. The parameters for the T1WI analysis were set as follows: slice thickness = 1 mm, TR = 2,300 ms, TE = 2.26 ms, acquisition matrix = 256*256, flip angle = 8°, and FOV = 256*256.

MRI (T1-weighted) data for baseline and follow-up scans were acquired using a 3-Tesla Skyra MRI (Siemens, Erlangen, Germany) at Monash Biomedical Imaging, Melbourne, Australia. The T1-weighted magnetization prepared rapid gradient echo (MPRAGE) images were acquired using the following parameters: acquisition time = 5 min 12 s, repetition time = 2300ms, echo time = 2.07ms, flip angle = 9°, field-of-view = 256mm, voxel size = 1 x 1 x 1 mm³, 192 slices per volume.