Tamoxifen, Tamoxifen-d5, 4-hydroxy-Tamoxifen (pure Z-trans-isomer, >98 % Z), 4-hydroxy-Tamoxifen-d5, N-desmethyl-Tamoxifen hydrochloride, N-desmethyl-Tamoxifen-d5, N-desmethyl-4-hydroxy-Tamoxifen (1:1 E/Z mixture) and N-desmethyl-4-hydroxy-Tamoxifen-d5 (1:1 E/Z mixture) were obtained from Toronto Research Chemicals (North York, ON, Canada). Optima-grade acetonitrile, methanol, water and certified ACS xylene were purchased from Fisher Scientific (Fair Lawn, NJ, USA). Formic acid and ammonium acetate were from Sigma-Aldrich (Oakville, ON, Canada). Bond Elut® C2 (100 mg, 3 mL) solid-phase extraction (SPE) cartridges were obtained from Agilent Technologies (Santa Clara, CA, USA).
Tamoxifen d5
Manufactured by LGC
Sourced in Canada
Tamoxifen-d5 is a deuterated form of the selective estrogen receptor modulator (SERM) drug Tamoxifen. It is used as an internal standard in analytical methods for the quantification of Tamoxifen and its metabolites in biological samples.
Automatically generated - may contain errors
Lab products found in correlation
Methanol, by Thermo Fisher Scientific (1 mentions)
4 hydroxy tamoxifen d5, by LGC (1 mentions)
N desmethyl 4 hydroxy tamoxifen d5, by LGC (1 mentions)
Optima grade acetonitrile, by Thermo Fisher Scientific (1 mentions)
Tamoxifen, by LGC (1 mentions)
4 hydroxytamoxifen, by LGC (1 mentions)
Ammonium acetate, by Merck Group (1 mentions)
Formic acid, by Merck Group (1 mentions)
Endoxifen, by LGC (1 mentions)
2 protocols using tamoxifen d5
1
Quantitative Analysis of Tamoxifen Metabolites
2
Liver Microsome-based Cytochrome P450 Assay
Check if the same lab product or an alternative is used in the 5 most similar protocols
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High/low cytochrome P450 (P450) activity human liver microsome (HLM) preparations from individual donors were purchased from BD Gentest (San Jose, CA). Pooled HLMs (150 donors) were purchased from Thermo Fisher Scientific (Waltham, MA). Endoxifen and tamoxifen-d5 were obtained from Toronto Research Chemicals (Toronto, ON, Canada). NADPH was purchased from Melford Laboratories (Ipswich, UK). All other chemicals were purchased from Sigma-Aldrich (Poole, UK).
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