Nitrendipine

Manufactured by Merck Group

Sourced in United States, France, Spain

Nitrendipine is a pharmaceutical compound used as a laboratory reagent. It functions as a calcium channel blocker, which is a class of drugs that inhibit the movement of calcium ions across cell membranes. This property makes nitrendipine a useful tool in scientific research and drug development.

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5 protocols using nitrendipine

Metabolic Pathways Inhibition Assay

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DSS was purchased from Affymetrix (Cleveland, OH, USA). Nifedipine (NFP, purity≥98%), oxidized NFP (NFPO, purity≥95%), nitrendipine (purity≥95%), diclofenac (DCF) sodium salt, dimethyl sulfoxide (DMSO), Tween 80, β-nicotinamide adenine dinucleotide phosphate, and reduced tetra (cyclohexyl ammonium) salt (NADPH) (purity≥97%) were from Sigma–Aldrich (St. Louis, MO, USA). CsA (purity≥99%), cyclosporine D (purity≥95%), 4′-OH-DCF-¹³C₆, 4′-OH-DCF, 5-OH-DCF, lovastatin hydroxy acid (LVA, purity≥95%), and simvastatin hydroxy acid sodium salt (SVA, purity≥95%) were obtained from Santa Cruz Biotechnology (Santa Cruz, CA, USA). Lovastatin (LVS, purity≥98%) and pravastatin sodium salt (PVS, purity≥98%) were purchased from Cayman Chemical (Ann Arbor, MI, USA). The solvents (acetonitrile, methanol and water) for high-performance liquid chromatography (HPLC) were from Thermo Fisher Scientific (Fisher Scientific, Houston, TX, USA).

Fan X., Ding X, & Zhang Q.Y. (2019). Hepatic and intestinal biotransformation gene expression and drug disposition in a dextran sulfate sodium-induced colitis mouse model. Acta Pharmaceutica Sinica. B, 10(1), 123-135.

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Investigating Sucralose, Leptin, and Nitrendipine

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Sucralose, leptin, and nitrendipine were purchased from Sigma (Sigma-Aldrich, St. Louis, MO). ω-Contoxin GIVA and ghrelin were purchased from Peptide Institute (Osaka, Japan). All of the other chemicals were purchased from Wako Pure Chemical Industries (Osaka, Japan).

Kohno D., Koike M., Ninomiya Y., Kojima I., Kitamura T, & Yada T. (2016). Sweet Taste Receptor Serves to Activate Glucose- and Leptin-Responsive Neurons in the Hypothalamic Arcuate Nucleus and Participates in Glucose Responsiveness. Frontiers in Neuroscience, 10, 502.

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HCMV Infection Response in THP-1 Cells and Monocyte-Derived DCs

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In all, 250,000 THP-1 cells were infected with HCMV strain Merlin at MOI = 5, then treated with 10 μM Nifedipine (Sigma-Aldrich), 5 μM Nitrendipine (Sigma-Aldrich) or DMSO 1hpi. RNA harvested 24hpi and analyzed by qRT-PCR for IE gene expression as above.
250,000 CD14+ monocytes were infected at MOI = 5 with HCMV strain Merlin and differentiated into monocyte-derived DCs as above. Cells were treated with 10 μM Nifedipine, 5 μM Nitrendipine (kind gifts from Jamal Mankouri, University of Leeds) or DMSO for 3h prior to stimulation with 50 ng/ml IL-6 as above. RNA was harvested 24hpi and analyzed for IE gene expression as above. Statistical comparisons were all performed via the non-parametric Kruskal–Wallis test with Dunn’s multiple testing correction in GraphPad Prism version 9.5.1.

Murray M.J., Bradley E., Ng Y., Thomas O., Patel K., Angus C., Atkinson C, & Reeves M.B. (2023). In silico interrogation of the miRNAome of infected hematopoietic cells to predict processes important for human cytomegalovirus latent infection. The Journal of Biological Chemistry, 299(6), 104727.

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Pharmacological Compound Procurement Protocol

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Rhodamine 123, amiodarone, carvedilol, cyclosporin A, diltiazem, elacridar, felodipine, fumitremorgin C, isradipine, itraconazole, mibefradil, nicardipine, nitrendipine, probenecid, quinidine, sertraline, troglitazone, verapamil, and zosuquidar were provided by Sigma–Aldrich (Saint-Quentin Fallavier, France).

Jouan E., Le Vée M., Mayati A., Denizot C., Parmentier Y, & Fardel O. (2016). Evaluation of P-Glycoprotein Inhibitory Potential Using a Rhodamine 123 Accumulation Assay. Pharmaceutics, 8(2), 12.

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Pharmacological Modulators of Cell Signaling

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Indomethacin, carbonyl cyanide-p-tri uoromethoxyphenylhydrazone (FCCP), Glibenclamide, nifedipine, nimodipine, nitrendipine, probenecid, reserpine, sodium azide and tamoxifen were from Merck-Sigma-Aldrich (Madrid-Spain); 5-nitro-2-(3-phenylpropylamino)-benzoic acid (NPPB) and sul npyrazone from ChemCruz (USA); ivermectin from alfa-aesar (Germany); imatinib, nilotinib and isradipine from Carbosynth (UK); Fumitremorgin-C, rifampicine and verapamil from MedChem Express (USA).

García-de-Diego A.M. (2023). C-subfamily ATP binding cassette transporters extrude the calcium fluorescent probe fluo-4 from a cone photoreceptor cell line. Naunyn-Schmiedeberg's archives of pharmacology, 396(8).

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