For in vitro CT imaging, TWNDs and clinical iodinated contrast agent (Iohexol) were dispersed in water with different concentrations in the range from 0 to 12 mg/ml. For in vivo CT imaging, the mice were first anesthetized by intraperitoneal injection of pentobarbital sodium solution (1 wt%), and then 0.1 mL of TWNDs (20 mg W mL−1) dispersion in physiological saline and 0.1 mL of Iohexol (20 mg I mL−1) were administrated intravenously into two mice, respectively. CT images were collected using a JL U.A NO.2 HOSP Philips iCT 256 slice scanner, imaging parameters were as follows: thickness, 0.9 mm; pitch, 0.99; 120 KVp, 300 mA; field of view, 350 mm; gantry rotation time, 0.5 s; table speed, 158.9 mm/s.
256 slice ict scanner
Manufactured by Philips
Sourced in Japan
The 256-slice ICT scanner is a medical imaging device designed for computed tomography (CT) scanning. It features a high-speed, high-resolution imaging system that can capture detailed images of the body's internal structures using X-ray technology. The scanner is capable of producing 256 slices of image data per rotation, enabling comprehensive and precise visualization of the scanned area.
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5 protocols using 256 slice ict scanner
1
Contrast-Enhanced CT Imaging of TWNDs
2
Multimodal Imaging for Complex Pediatric Surgical Oncology
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In complex pediatric surgical oncology cases, in which soft tissue and bone are involved and are important to help assess the differential diagnosis and treatment approach, both CT and MRI are needed.
For the assessment of the vascular–tumor relationships in the Case #1 patient, an abdominal CT angiography with contrast was performed.
In Case #2, the patient underwent a neck and thoraco-abdominal CT scan with endovascular venous phase contrast (split-bolus technique).
Finally, for Case #3, a combination of MRI and CT images was required. An abdominal MRI was performed, acquiring T1 and T2 sequences in all three planes of space, along with diffusion-weighted images. The abdominal and pelvic angio-CT was performed using the split-bolus technique. The CT scan was performed using a Philips iCT 256 slice scanner.
After image acquisition, post-processing was performed to obtain the imaging projections and 3D models for surgical planning and differential diagnosis assessment. Medical imaging post-processing and planning techniques can be divided into three types: (1) imaging projections (Multiplanar Reconstruction (MPR), Volume Rendering (VolR), Maximal Intensity Projection (MIP), or Cinematic Rendering (CR)); (2) Computer Aided Design (CAD) 3D models, which can be viewed using specialized software and devices such as screen, VR, or AR headsets, and (3) 3D printed models.
For the assessment of the vascular–tumor relationships in the Case #1 patient, an abdominal CT angiography with contrast was performed.
In Case #2, the patient underwent a neck and thoraco-abdominal CT scan with endovascular venous phase contrast (split-bolus technique).
Finally, for Case #3, a combination of MRI and CT images was required. An abdominal MRI was performed, acquiring T1 and T2 sequences in all three planes of space, along with diffusion-weighted images. The abdominal and pelvic angio-CT was performed using the split-bolus technique. The CT scan was performed using a Philips iCT 256 slice scanner.
After image acquisition, post-processing was performed to obtain the imaging projections and 3D models for surgical planning and differential diagnosis assessment. Medical imaging post-processing and planning techniques can be divided into three types: (1) imaging projections (Multiplanar Reconstruction (MPR), Volume Rendering (VolR), Maximal Intensity Projection (MIP), or Cinematic Rendering (CR)); (2) Computer Aided Design (CAD) 3D models, which can be viewed using specialized software and devices such as screen, VR, or AR headsets, and (3) 3D printed models.
3
Abdominal CT Imaging Protocol
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The Discovery CT750 HD scanner (GE Medical Systems, Milwaukee, WI, USA), Toshiba Aquilion 64-slice spiral CT scanner (Tokyo harbor area, Japan), Philips 256-slice ICT scanner (Amsterdam, The Netherlands), and Philips brilliance 64-slice CT scanner (Amsterdam, The Netherlands) were used for CT scanning. After fasting for 6-8 h, the patient had warm water (500-1000 mL) 10 min before the examination with plain and enhanced abdominal scanning in the supine position. The scanning parameters were as follows: slice thickness 5 mm, pitch 0.9-1.0, scanning field 350 mm×350 mm, matrix 512×512, tube voltage 100–120 kV, tube current 160–300 mA, and X-ray tube rotation time 0.5–0.8 s. The contrast agent was injected through the elbow vein at a flow rate of 3.0–3.5 mL/s and a dose of 1.0–1.2 mL/kg body weight. The scanning time of the arterial phase, venous phase, and delayed phase was 30-35 s, 50-60 s, and 180 s, respectively, after injection of contrast agent. The CT images at the arterial and venous phase were selected for imaging analysis.
4
Quantification of Hepatic Steatosis via CT
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Images were obtained using a Philips 256-slice iCT scanner operated by an experienced CT examination technician. All subjects were scanned from the top of the diaphragm to the lower costal margin in the supine position after fasting overnight. The scan began when the subjects hold their breath at the end of the exhalation. The scan parameters were as follows: tube voltage, 120 kV; tube current, 250 mA; slice thickness and interval, 5 mm; field of view (FOV), 40 cm × 40 cm; window level, 40 Hu; window width, 400 Hu.
The measurement of CT value, which was designed referring to the research of Yu et al. [14 (link)], was as follows: three region-of-interest (ROI) in the liver and two ROIs in the spleen were selected at the level of porta hepatis to avoid blood vessels, bile ducts, and calcification. Each ROI was a circle of about 300 mm2. The respective means of the 3 CT values of the liver and 2 CT values of the spleen were calculated as the liver and the spleen CT value. The liver/spleen CT ratio, defined as liver CT value to spleen CT value, was calculated to reflect the degree of steatosis, which determined the severity of MAFLD.
The measurement of CT value, which was designed referring to the research of Yu et al. [14 (link)], was as follows: three region-of-interest (ROI) in the liver and two ROIs in the spleen were selected at the level of porta hepatis to avoid blood vessels, bile ducts, and calcification. Each ROI was a circle of about 300 mm2. The respective means of the 3 CT values of the liver and 2 CT values of the spleen were calculated as the liver and the spleen CT value. The liver/spleen CT ratio, defined as liver CT value to spleen CT value, was calculated to reflect the degree of steatosis, which determined the severity of MAFLD.
5
Multimodal Imaging Protocol for Comprehensive Diagnosis
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CT was performed using a Philips 256 Slice iCT scanner (Philips, Best, The Netherlands) at 240 mA, 120 kV, 5 mm/slice, scanning speed of 1 slice/s, W80 HU, and C4050 HU. MRI was performed using a Siemens 3.0-T MRI (Siemens, Erlangen, Germany) with a maximum gradient strength of 45 mT/m and a maximum slew rate of 200 mT/m/s. The transmitting and receiving coils were 12-channel standard head-array coils. PET/CT was performed using a GE multifunctional whole-body PET/CT scanner, with PET acquisition parameters of FOV = 256 × 256 mm, array of 128 × 128, slice thickness of 2 mm, and time of 10 min, while CT scanning parameters were set as 120 kV, 150 mA, slice thickness of 3.2 mm, and pitch of 0.938. CT data were used for attenuation correction of PET images, and cross section images were obtained by 3D LOR-RAM LA reconstruction.
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