3 t achieva scanners

Subjects underwent locally optimized brain MRI protocols including 3D-T1, fluid attenuated inversion recovery (FLAIR), susceptibility weighted imaging (SWI), diffusion tensor imaging (DTI) and resting state functional MRI (rs-fMRI). MRI scans were performed on Philips 3 T Achieva scanners. Additionally, in Manchester regional cerebral blood flow was measured by arterial spin labelling [96 (link)], but no DTI scan was acquired in Manchester. In Amsterdam, if a subject could not undergo the MRI scan, we considered a CT scan (Philips Ingenuity TF or Gemini TF camera). Scans will be analyzed locally and centrally by EMIF-AD partners using the Neugrid infrastructure if applicable (see Additional file 1).

MRIs were conducted using 1.5-T Intera or 3-T Achieva scanners (Philips, Best, the Netherlands). The MRI protocol included fluid-attenuated inversion recovery (FLAIR), time-of-flight MR angiography (TOF-MRA), T2-gradient echo, and diffusion-weighted imaging (DWI) sequences. The DWI lesion was outlined using a semiautomated method (3D Slicer, https://www.slicer.org). The DWI-based Alberta Stroke Program Early CT Score (ASPECTS) was assessed (21 (link)). The Thrombolysis in Cerebral Infarction (TICI) score was used to assess angiographic reperfusion, and the treatment was considered successful if the score was 2b, 2c, or 3 (22 (link)). Hemorrhagic transformations were evaluated on day-1 CT using the European Co-operative Acute Stroke Study-II (ECASS II) classification (23 (link)). The follow-up MRI protocol at day 6 included FLAIR sequence.