Large preparations of VNI, FF-VNI, VFV, and F-VFV were synthesized by the Chemical Synthesis Core Facility (Vanderbilt Institute of Chemical Biology),34 (link) and synthesis of their analogues CF3F-VNI and VFV-Cl has been described previously.9 (link),10 (link) The purity of the compounds was >95%. Voriconazole, ketoconazole, itraconazole, and posaconazole were purchased from Santa Cruz Biotechnology (Dallas, TX); isavuconazole was from Sigma-Aldrich, and fluconazole was from ICN Biomedicals. Hydroxypropyl-β-cyclodextrin (HPCD) was purchased from Cyclodextrin Technology Development (Gainesville, FL). DEAE- and CM-Sepharose resins were from GE Healthcare, and Ni2+-nitrilotriacetate (NTA) agarose was purchased from Qiagen.
Fluconazole
Manufactured by ICN Biomedicals
Fluconazole is an antifungal medication used to treat a variety of fungal infections. It is a triazole antifungal agent that works by inhibiting the biosynthesis of ergosterol, a vital component of the fungal cell membrane.
Automatically generated - may contain errors
Lab products found in correlation
Ketoconazole, by Santa Cruz Biotechnology (2 mentions)
Posaconazole, by Santa Cruz Biotechnology (2 mentions)
Voriconazole, by Santa Cruz Biotechnology (2 mentions)
Ni2 nitrilotriacetate nta agarose, by Qiagen (2 mentions)
Itraconazole, by Santa Cruz Biotechnology (1 mentions)
Isavuconazole, by Merck Group (1 mentions)
Letrozole, by Santa Cruz Biotechnology (1 mentions)
Clotrimazole, by Santa Cruz Biotechnology (1 mentions)
Miconazole, by Santa Cruz Biotechnology (1 mentions)
2 protocols using fluconazole
1
Synthesis and Characterization of Novel Antifungal Compounds
2
Synthesis and Characterization of Azole Antifungals
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
The azole-based drugs ketoconazole, posaconazole,
voriconazole, ravuconazole, clotrimazole, miconazole, letrozole, and
anastrozole were purchased from Santa Cruz Biotechnology (Dallas,
TX), and fluconazole was from ICN Biomedicals. VNI and VFV were synthesized
by the Chemical Synthesis Core Facility (Vanderbilt Institute of Chemical
Biology).70 (link) The synthesis of their analogue
LFV was described previously.68 (link) The purity
of the compounds was >95%. The pyridine derivatives UDO and UDD
were
from DNDi;46 (link) the tetrazole-based compounds
VT116147 (link) and VT159848 (link) were from Mycovia Pharmaceuticals (Durham, NC). Hydroxypropyl-β-cyclodextrin
(HPCD) was purchased from Cyclodextrin Technology Development (Gainesville,
FL). Q- and CM-Sepharose resins were from GE Healthcare, and Ni2+-nitrilotriacetate (NTA) agarose was from Qiagen. The synthesis
of the CYP51 reaction product (3β,5α)-4,4-dimethyl-cholesta-8,14,24-trien-3-ol
(dihydro-FF-MAS) was reported elsewhere.71 (link) All compounds were >95% pure by high-performance liquid chromatography
(HPLC).
voriconazole, ravuconazole, clotrimazole, miconazole, letrozole, and
anastrozole were purchased from Santa Cruz Biotechnology (Dallas,
TX), and fluconazole was from ICN Biomedicals. VNI and VFV were synthesized
by the Chemical Synthesis Core Facility (Vanderbilt Institute of Chemical
Biology).70 (link) The synthesis of their analogue
LFV was described previously.68 (link) The purity
of the compounds was >95%. The pyridine derivatives UDO and UDD
were
from DNDi;46 (link) the tetrazole-based compounds
VT116147 (link) and VT159848 (link) were from Mycovia Pharmaceuticals (Durham, NC). Hydroxypropyl-β-cyclodextrin
(HPCD) was purchased from Cyclodextrin Technology Development (Gainesville,
FL). Q- and CM-Sepharose resins were from GE Healthcare, and Ni2+-nitrilotriacetate (NTA) agarose was from Qiagen. The synthesis
of the CYP51 reaction product (3β,5α)-4,4-dimethyl-cholesta-8,14,24-trien-3-ol
(dihydro-FF-MAS) was reported elsewhere.71 (link) All compounds were >95% pure by high-performance liquid chromatography
(HPLC).
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