All images were acquired using a 3T Signa Excite HDx system (GE Healthcare, Milwaukee, WI) with an 8-channel dedicated head coil. Images were acquired before start of RT and at approximately one year (9–15 months) after start of RT. The standardized protocol included a 3-dimensional (3D) volumetric T1-weighted inversion recovery spoiled gradient-echo sequence (TE, 2.8 ms; TR, 6.5 ms; TI, 450 ms) obtained both pre- and post-infusion of IV gadolinium contrast, as well as a 3D T2-weighted FLAIR sequence (TE, 126 ms; TR, 6000 ms; TI, 1863 ms).
Signa excite hdx
Manufactured by GE Healthcare
Sourced in United States, United Kingdom
The Signa Excite HDx is a magnetic resonance imaging (MRI) system developed by GE Healthcare. It is designed to provide high-quality medical imaging for diagnostic purposes. The system uses a powerful magnetic field and radio waves to generate detailed images of the body's internal structures.
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Lab products found in correlation
Discovery mr750, by GE Healthcare (4 mentions)
Omniscan, by GE Healthcare (2 mentions)
Magnevist, by Bayer (2 mentions)
Sonata 1.5t, by Siemens (2 mentions)
Magnetom trio, by Siemens (1 mentions)
Magnetom verio, by Siemens (1 mentions)
8 channel head coil, by GE Healthcare (1 mentions)
Verio 3t mri, by Siemens (1 mentions)
Verio 3t, by Siemens (1 mentions)
Cartigram, by GE Healthcare (1 mentions)
Brainamp mr, by Brain Products (1 mentions)
Magnetom trio, by Philips (1 mentions)
Brainamp amplifier, by Brain Products (1 mentions)
Clone j43, by BioXCell (1 mentions)
29 protocols using signa excite hdx
1
Longitudinal MRI Evaluation of RT Effects
2
Diffusion-Weighted MRI Protocol for Whole-Brain Imaging
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All subjects underwent diffusion weighted MRI acquisition on the same scanner, 3T GE Signa Excite HDx, as described previously (Sinha et al., 2020 ; Taylor et al., 2018 ; Winston et al., 2013 ). Diffusion MRI data were acquired using a cardiac‐triggered single‐shot spin‐echo planar imaging sequence (Wheeler‐Kingshott et al., 2002 ) with echo time =73 ms. Sets of 60 contiguous 2.4 mm‐thick axial slices were obtained covering the whole brain, with diffusion sensitising gradients applied in each of 52 noncollinear directions (b value of 1,200 mm2 s − 1 [δ = 21 ms, Δ = 29 ms, using full gradient strength of 40 mT m − 1]) along with 6 non‐diffusion weighted scans. The gradient directions were calculated and ordered as described elsewhere (Cook et al., 2007 ). The field of view was 24 cm, and the acquisition matrix size was 96 × 96, zero filled to 128 × 128 during reconstruction, giving a reconstructed voxel size of 1.875 × 1.875 × 2.4 mm. The DTI acquisition time for a total of 3,480 image slices was approximately 25 min (depending on subject heart rate).
3
PET Imaging Alignment with MRI-based AC-PC Line
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Prior to PET scanning, brain MRI (1.5-T GE, Signa Excite HDx, GE Medical Systems, Milwaukee, WI) was performed with three-dimensional mode sampling to determine the areas for setting region of interest (ROI), using the following acquisition parameters: repetition time = 25.0, echo time = minimum, flip angle 30°, slice thickness 1.5 mm, matrices 256 × 128, and field of view = 24.0. With reference to the measures of tilt angle and spatial coordinates obtained to determine the anterior commissure–posterior commissure (AC–PC) line on each participant’s sagittal MRI, a PET gantry was set as parallel to the AC–PC line by tilting and moving the gantry for each study. The MRI measurements and mobile PET gantry allow us to reconstruct PET images parallel to the AC–PC line without reslicing.
4
Femoral MRI-CT Characterization in Piglets
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Experiments were carried out on thirty healthy piglets with the approval of the Shengjing Hospital of China Medical University Institutional Animal Investigation Committee. The MR images were obtained with a GE 3.0-T MR scanner (Signa Excite HDx; GE Healthcare, Milwaukee, WI, USA) and the CT images were obtained with a 64-slice CT system (Philips Healthcare Company, Cleveland, USA). The piglets were then sacrificed and dissected and their femora were entirely removed for dried-femur measurement. After the experiments were completed, FA was measured using MR and CT 3D postprocessing software.
5
Multimodal Neuroimaging Data Acquisition
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All but one of the scans were acquired on a 3.0 Tesla General Electric Signa Excite HDx (Waukesha, WI) clinical MRI system with an eight-channel head receive-only coil. FMRI pulse sequences consisted of an echo-planar gradient-echo sequence with repetition time TR = 2 s, echo time TE = 30 ms, flip angle = 70°, axial field of view 24 cm, slice thickness = 5 mm, matrix size = 64 × 64 × 28, 180 time samples. DMRI scans were obtained using a spin-echo diffusion tensor pulse sequence with one T2-weighted image, 55 diffusion-weighted images evenly distributed on a sphere with b = 1000 s/mm2, minimum TE, TR = 13.5 s, field of view = 23 cm, slice thickness = 1.8 mm, matrix size = 128 × 128 × 72 (yielding isotropic resolution), reconstructed with zero filling to 256 × 256 × 72, covering the whole brain. Anatomical imaging was performed with an axial 3D-IRFSPGR sequence (BRAVO) with inversion time = 400 ms, TR = 8.864 ms, TE = 3.524 ms, flip angle = 13°, axial field of view = 24 cm, slice thickness = 1.2 mm, matrix size = 256 × 256 × 120, parallel imaging acceleration factor = 2.
6
Multimodal Neuroimaging for Cognitive Function
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Between 2009 and 2013,80 patients were scanned on a 3T GE Signa Excite HDx. Single-shell dMRI data were acquired using a cardiac-triggered single-shot spin-echo planar imaging sequence14 (link): 1.875 × 1.875 × 2.4 mm resolution, gradient directions: 6 and 52 at b values: 0 and 1,200/mm2, and δ/Δ/TE = 21/29/73 ms, and a 3D T1-weighted sequence was acquired as described in Taylor et al.17 (link) Task-based verbal fluency and generation14 (link) gradient-echo planar T2*-weighted fMRI were acquired with 58 contiguous 2.5-mm oblique axial slices, 96 × 96 matrix reconstructed to 128 × 128 for an in-plane resolution of 1.875 × 1.875 mm (TE/TR = 25/2,500 ms).
Between 2014 and 2019, 47 patients were scanned on a 3T GE Discovery MR750. A 3D T1-weighted sequence (MPRAGE) was acquired as described in Vos et al.,18 (link) and multishell dMRI data were acquired (2 mm isotropic resolution, gradient directions: 11, 8, 32, and 64 at b values: 0, 300, 700, and 2,500 s/mm2; ∂/Δ = 21.5/35.9 ms, and TE/TR = 74.1/7,600 ms). Task-based verbal fluency and generation14 (link) gradient-echo planar T2*-weighted fMRI were acquired with 50 contiguous 2.4-mm (0.1 mm gap) slices with a 24-cm field of view, 64 × 64 matrix with an in-plane voxel size of 3.75 × 3.75 mm (TE/TR = 22/2,500 ms).
Between 2014 and 2019, 47 patients were scanned on a 3T GE Discovery MR750. A 3D T1-weighted sequence (MPRAGE) was acquired as described in Vos et al.,18 (link) and multishell dMRI data were acquired (2 mm isotropic resolution, gradient directions: 11, 8, 32, and 64 at b values: 0, 300, 700, and 2,500 s/mm2; ∂/Δ = 21.5/35.9 ms, and TE/TR = 74.1/7,600 ms). Task-based verbal fluency and generation14 (link) gradient-echo planar T2*-weighted fMRI were acquired with 50 contiguous 2.4-mm (0.1 mm gap) slices with a 24-cm field of view, 64 × 64 matrix with an in-plane voxel size of 3.75 × 3.75 mm (TE/TR = 22/2,500 ms).
7
Whole Brain MRI Analysis Protocol
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Whole heads were collected on D19 p.b., fixed in 4% PFA for 96 h, and transferred to PBS until ready for MRI imaging. All MRI images were acquired with a GE Signa Excite HDx MR machine with a 3.0 T magnet. The skulls were individually placed into the Mayo Clinic BC-10 Wrist Coil (Part #13G5614) and imaged using a Transverse T2 fast spin echo sequence. Sequence parameters included an 85 ms echo time (TE), 3350 ms repetition time (TR), 4 cm field of view, 12 echo train length (ETC), and 3 averages, with 1.0 mm slice thickness and 0.0 mm slice spacing. Image segmentation, 3D reconstruction, and dimensional quantifications were performed using Scan IP (Simpleware, United Kingdom).
8
Pelvic MRI Protocol for CCRT
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All patients underwent routine contrast-enhanced pelvic MRI before CCRT. MRI acquisitions were performed on two 3.0-T MR imaging units (Discovery MR 750 and Signa Excite HDx, GE Medical System) using an eight-element phased coil with patients in the supine position. Patients with no contraindications received an intramuscular injection of 10 mg raceanisodamine hydrochloride before image acquisition to reduce bowel motion artifacts. DWI was performed using a single-shot spin echo-planar imaging sequence with b values of 0 and 800 s/mm2. Sagittal multi-phase contrast enhanced scannig was performed using liver acquisition with volume acceleration-extended volume (LAVA-XV) sequence 15 seconds after an intravenous injection contrast agent (gadodiamide, 0.1 mmol/kg; Omniscan; GE Healthcare, Co. Cork, Ireland) at a rate of 2.0 ml/s, per phase of 15 seconds with a total acquisition time of 105 seconds, followed by 20 mL of normal saline to flush the tubing. Detailed information on the MR sequences is listed in Supplementary Table S1 .
9
Multimodal Neuroimaging Protocol for Clinical Research
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Between 2009 and 2013 (N = 27) patients were scanned on a 3 T GE Signa Excite HDx (Taylor et al., 2018 (link)). Single-shell dMRI data were acquired using a cardiac-triggered single-shot spin-echo planar imaging sequence (Wheeler-Kingshott et al., 2002 (link)): 1.875 × 1.875 × 2.4 mm resolution, gradient directions: 6 and 52 at b-values: 0 and 1200/ mm2, δ/Δ/TE = 21/29/73 ms, and a 3D T1-weighted sequence was acquired. For verbal fluency fMRI (Tombaugh et al., 1999 (link)) gradient-echo planar T2*-weighted images were acquired with 58 contiguous 2.5 mm oblique axial slices, 96 × 96 matrix reconstructed to 128 × 128 for an in-plane resolution of 1.875 × 1.875 mm (TE/TR = 25/2500 ms).
Between 2014 and 2019 (N = 17) patients were scanned on a 3 T GE Discovery MR750 (Taylor et al., 2018 (link)). A 3D T1-weighted sequence (MPRAGE) was acquired and multi-shell dMRI (2 mm isotropic resolution, gradient directions: 11, 8, 32, and 64 at b-values: 0, 300, 700, and 2500 s/mm2; ∂/Δ = 21.5/35.9 ms, TE/TR = 74.1/7600 ms). For verbal fluency fMRI (Tombaugh et al., 1999 (link)) gradient-echo planar T2*-weighted images was acquired with 50 contiguous 2.4 mm (0.1 mm gap) slices with a 24 cm field of view, 64 × 64 matrix with an in-plane voxel size of 3.75 × 3.75 mm (TE/TR = 22/2500 ms).
Between 2014 and 2019 (N = 17) patients were scanned on a 3 T GE Discovery MR750 (Taylor et al., 2018 (link)). A 3D T1-weighted sequence (MPRAGE) was acquired and multi-shell dMRI (2 mm isotropic resolution, gradient directions: 11, 8, 32, and 64 at b-values: 0, 300, 700, and 2500 s/mm2; ∂/Δ = 21.5/35.9 ms, TE/TR = 74.1/7600 ms). For verbal fluency fMRI (Tombaugh et al., 1999 (link)) gradient-echo planar T2*-weighted images was acquired with 50 contiguous 2.4 mm (0.1 mm gap) slices with a 24 cm field of view, 64 × 64 matrix with an in-plane voxel size of 3.75 × 3.75 mm (TE/TR = 22/2500 ms).
10
Pituitary Tumor Measurement and Optic Nerve Analysis
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Preoperative MRI images of the pituitary region were obtained for all patients using a 3-T scanner (MAGNETOM Trio; Siemens, Munich, Germany; or Signa Excite HDx; GE Healthcare, Tokyo, Japan). Pre-enhanced T1- and T2-weighted images and post-enhanced T1-weighted images were obtained for all patients in the sagittal and coronal planes with a 1.5 mm slice thickness. Tumor measurements were defined as follows: maximum craniocaudal diameter was defined as the tumor height; vertical length from the anterior skull base to the top of the tumor was defined as the tumor’s top-anterior skull base distance; and cavernous sinus invasion of the tumor was evaluated based on the Knosp grade on coronal images.[17 (link)] The angle formed by the optic nerve in the optic canal and the intracranial subarachnoid space at the exit of the optic canal was defined as the sagittal optic nerve canal bending angle (ONCBA). This angle was measured at the entrance of the optic canal on T2-weighted sagittal images [Figure 2 ].[26 (link)] Two independent observers (M.D. and Y.S.) measured the above using customizable MRI image software (Digital Imaging and Communication in Medicine viewer EV Insite R (PSP Corporation, Tokyo, Japan) and assessed the average.
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