Ge discovery elite 690

The PET imaging studies in this work were conducted according to literatures.^{30 (link), 52 (link)} T1-weighted MR anatomical images were acquired on a 3.0 T scanner (GE Discovery 750, Milwaukee, USA). The rhesus was anesthetized with ketamine (10 mg/kg; intramuscular injection) and placed into the scanner in the supine position. A circular 32-channel array head coil was placed on top of the monkey’s head. The whole-brain images were acquired with a 3D Bravo T1 sequence.
A male rhesus (weight range 5.94–6.16 kg) underwent PET scan (GE Discovery Elite 690, USA). The rhesus was anesthetized with ketamine (10 mg/kg; i.m.), placed into the scanner, and maintained in light narcosis with 2% isoflurane and 98% oxygen. The body of the subject was in the supine position. A solution of [¹⁸F]10 or [¹⁸F]15 (3.34–3.95 mCi) in saline was injected into the monkey via a flexible percutaneous venous catheter. The baseline PET/CT scan were repeated twice within 10 days. For the blocking study, the blocking reagent JNJ-42226314 (0.9 mg/kg) was injected intravenously, followed by the injection of [¹⁸F]15.

All PET/CT studies were performed using one of 4 PET/CT systems available in our department (GE Discovery 690 Elite, 600, ST, or LS; General Electric, Milwaukee, Wis). Patients fasted at least 4 hours before the scan, and were imaged approximately 60 minutes after radiotracer injection. Scans were obtained from skull vertex to mid thigh with arms down. All PET data was reconstructed with and without CT-based attenuation correction. The emission scan lasted for 2–4 minutes for each bed position.

All PET/CT studies were performed using one of 4 PET/CT systems (GE Discovery 690 Elite, 600, ST, or LS; General Electric, Milwaukee, Wis). Patients fasted at least 4 hours before the scan, and were imaged approximately 60 minutes after radiotracer injection. Patients were instructed not to talk during uptake time. Scans were obtained from skull vertex to mid thigh with arms down. All PET data was reconstructed with and without CT-based attenuation correction. The emission scan lasted for 2-4 minutes for each bed position.

All PET/CT studies were performed using one of 4 PET/CT systems (GE Discovery 690 Elite, 600, ST, or LS; General Electric, Milwaukee, Wisc.). Patients fasted at least 4 hours before the scan, and were imaged approximately 60 minutes after radiotracer injection. Patients were instructed not to talk during incubation period. Scans were obtained from skull base to mid thigh. All PET data was reconstructed with and without CT-based attenuation correction. The emission scan lasted for 2–4 minutes for each bed position.