Cyclohexane acs

Ezetimibe (EZT,(3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxy- propyl]-4-(4-hydroxyphenyl)azetidin-2-one, >99.5%, Hangzhou Hyper Chemicals Limited, Zhejiang, China) was used as a model drug. Vinylpyrrolidone-vinyl acetate copolymer (Kollidon^®VA64, PVP/VA, BASF, Ludwigshafen am Rhein, Germany) was used as an excipient. Sodium lauryl sulfate (SLS, BASF, Ludwigshafen am Rhein, Germany) was used to prepare dissolution medium. Ethanol (absolute, 99.8%, pure p.a., Avantor Performance Materials Poland, Gliwice, Poland) was used as a solvent in spray drying processes. Cyclohexane (ACS, pure p.a., Avantor Performance Materials, Gliwice, Poland) was used as a dispersant in laser diffraction measurements. All chemicals were used as received. Distilled water was used to prepare all aqueous solutions.

Bicalutamide (BCL, N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide, 99.8%, Hangzhou Hyper Chemicals Limited, Zhejiang, China) was used as the model drug. Polyvinylpyrrolidone K29/32 (PVP, Ashland, Covington, KY, USA) was used as an excipient. Sodium lauryl sulfate (SLS, BASF, Ludwigshafen am Rhein, Germany) was used to prepare the dissolution medium. Ethanol (absolute, 99.8%, pure p.a., Avantor Performance Materials, Gliwice, Poland) was used as a solvent in evaporation processes. Cyclohexane (ACS, pure p.a., Avantor Performance Materials, Gliwice, Poland) was used as a dispersant in laser diffraction measurements. All chemicals were used as received. Distilled water was used to prepare all of the aqueous solutions.