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Nicotinic acid

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Nicotinic acid, also known as niacin, is a naturally occurring organic compound that serves as a precursor to the essential coenzymes NAD and NADP. It is commonly used in various laboratory applications as a reagent or buffer component.

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Lab products found in correlation

Fumaric acid, by Cambridge Isotopes (2 mentions) Deuterated picolinic acid, by Thermo Fisher Scientific (2 mentions) Dl glutamic acid, by Cambridge Isotopes (2 mentions) L tryptophan, by Cambridge Isotopes (2 mentions) Acetonitrile acn, by Thermo Fisher Scientific (2 mentions)

2 protocols using nicotinic acid

1

Quantitative Metabolite Analysis Protocol

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Formic acid (FA), methanol (MeOH), dimethylsulfoxid (DMSO) and acetonitrile (ACN) of analytical grade were from Fisher Scientific (Pittsburgh, PA, USA). Water was of ultrapure grade (EMD Millipore Co., Billerica, MA, USA). Deuterated standards {Fumaric acid (2,3-D2, 98% purity), DL-Glutamic acid (2,4,4-D3, 98% purity), L-Tryptophan (indole-D5, 98% purity) and Nicotinic acid (D4, 98% purity)} were from Cambridge Isotope Laboratories (Cambridge Isotope Laboratories Inc., Tewksbury, MA, USA). Deuterated Anthranilic acid (3,4,5,6-D4, 98% purity), Kynurenic acid (3,4,6,7,8-D5, 98% purity), Kynurenine (D4, 98% purity), Quinolinic acid (4,5,6-D3, 99% purity), 3-Hydroxy-DL-kynurenine (5,8,8-D3, 98% purity), 3-Hydroxyanthranilic acid (4,6-D2, 98% purity) were from Buchem (Buchem BV, Apeldoorn, The Nederlands). Deuterated Picolinic acid (99% purity) was from Acros Organics (Thermo Fisher Sci, NJ, USA). Commercial calibration solutions for the MS device were from Thermo Scientific (Thermo Fisher Sci., San José, CA, USA).
Triplett T.A., Garrison K.C., Marshall N., Donkor M., Blazeck J., Lamb C., Qerqez A., Dekker J.D., Tano Y., W.e.i.-.C.h.e.n.g.-.L.u., Karamitros C.S., Ford K., Tan B., Zhang M., McGovern K., Coma S., Kumada Y., Yamany M.S., Sentandreu E., Fromm G., Tiziani S., Schreiber T.H., Manfredi M., Ehrlich L.I., Stone E, & Georgiou G. (2018). Reversal of IDO-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme. Nature biotechnology, 36(8), 758-764.
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2

Quantitative Metabolite Analysis Protocol

Check if the same lab product or an alternative is used in the 5 most similar protocols
Formic acid (FA), methanol (MeOH), dimethylsulfoxid (DMSO) and acetonitrile (ACN) of analytical grade were from Fisher Scientific (Pittsburgh, PA, USA). Water was of ultrapure grade (EMD Millipore Co., Billerica, MA, USA). Deuterated standards {Fumaric acid (2,3-D2, 98% purity), DL-Glutamic acid (2,4,4-D3, 98% purity), L-Tryptophan (indole-D5, 98% purity) and Nicotinic acid (D4, 98% purity)} were from Cambridge Isotope Laboratories (Cambridge Isotope Laboratories Inc., Tewksbury, MA, USA). Deuterated Anthranilic acid (3,4,5,6-D4, 98% purity), Kynurenic acid (3,4,6,7,8-D5, 98% purity), Kynurenine (D4, 98% purity), Quinolinic acid (4,5,6-D3, 99% purity), 3-Hydroxy-DL-kynurenine (5,8,8-D3, 98% purity), 3-Hydroxyanthranilic acid (4,6-D2, 98% purity) were from Buchem (Buchem BV, Apeldoorn, The Nederlands). Deuterated Picolinic acid (99% purity) was from Acros Organics (Thermo Fisher Sci, NJ, USA). Commercial calibration solutions for the MS device were from Thermo Scientific (Thermo Fisher Sci., San José, CA, USA).
Triplett T.A., Garrison K.C., Marshall N., Donkor M., Blazeck J., Lamb C., Qerqez A., Dekker J.D., Tano Y., W.e.i.-.C.h.e.n.g.-.L.u., Karamitros C.S., Ford K., Tan B., Zhang M., McGovern K., Coma S., Kumada Y., Yamany M.S., Sentandreu E., Fromm G., Tiziani S., Schreiber T.H., Manfredi M., Ehrlich L.I., Stone E, & Georgiou G. (2018). Reversal of IDO-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme. Nature biotechnology, 36(8), 758-764.
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