6-hydroxidopamine (6-OHDA), desipramine, apomorphine, ellagic acid (EA) and pramipexole (PPX) were purchased from Sigma-Aldrich Chemical Co. (St. Louis, MO, USA). Ketamine/xylazine were obtained from Alfasan Co. (Woerden, Holland).
Ketamine xylazine
Manufactured by Alfasan
Ketamine/xylazine is a combination of two anesthetic agents commonly used in veterinary medicine. Ketamine is a dissociative anesthetic that induces a trance-like state, while xylazine is a sedative and muscle relaxant. This combination is often used to produce anesthesia and analgesia in various animal species.
Automatically generated - may contain errors
2 protocols using ketamine xylazine
1
Parkinson's Disease Pharmacological Intervention
2
Nanoemulsion for Osteoarthritis Pain Relief
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Evaluating the anti-nociceptive effects of the nanoemulsion, osteoarthritis was induced by intra-articular injection of monosodium iodoacetate (MIA). Briefly, rats were anesthetized with Ketamine-Xylazine (100–10 mg/kg, I.P.) (Alfasan, The Netherlands) and 2 mg of MIA (Sigma-Aldrich, USA) dissolved in 25 μl sterile normal saline was injected into the left knee joint with a 27-gauge needle inserted through the intra-patellar tendon. Control animals were given a single injection of the vehicle into the left knee joint [21 (link)]. In this study, 36 rats were randomly divided into six groups (n = 6 for each) including Control (CO), Osteoarthritis (OA), Osteoarthritis received gel contained the nanoemulsion (NG), Osteoarthritis received gel contained Mentha and Rosemary essential oils (EG), Osteoarthritis received the nanoemulsion solution (NS), and Osteoarthritis received gel contained 1% diclofenac sodium (Razak Co., Iran) (DG). Gels and solutions were topically applied at a dose of 1 ml on injected knee daily for 14 days.
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