Poloxamer 127

Beijing Mesochem Technology Co. Pvt. Ltd. (Beijing, China) provided the Piperine (98.21% purity). Eucalyptus oil, Almond oil, Sunflower oil, and Ethyl oleate were procured from SD-fine chemicals (Mumbai, India). Labrafac WL, Caprol PGE-860, Capmul MCM, Labrafil M1944 CS, and Transcutol HP were procured from the Gattefosse Mumbai, India. Glyceryl monolinoleate (GML) Cremophor RH 40, Solutol HS 15, and Span 20 were obtained from the BASF India Ltd. (Bandra East, Mumbai, India). Polyethylene glycol-400 (PEG-400), PEG200, propylene glycol (PG), and hydrochloric acid were purchased from Acros organic (Mumbai, India). Poloxamer188, poloxamer 127, and avicel PH101 were obtained from Sigma Aldrich (St Louis, MO, USA).

Osthol (high performance piquid chromatography (HPLC) purity > 95%) was purchased from Qingze Lvsheng Plant Co., Ltd. (Nanjing, China). Poloxamer-127 and Trypsin were obtained from Sigma (Schnelldorf, Germany) and the poly-butyl cyanoacrylate was purchased from Shunkang Medical Adhesion Co., Ltd. (Beijing, China). DMEM-F12 medium was purchased from Hyclone (Logan, UT, USA), Fetal Bovine Serum (FBS) was obtained from Gibco (Grand Island, NY, USA), and 3-(4, 5-Dimethylthiazole-2)-2, 5-diphenyltetrazolium bromide (MTT) was purchased from Amresco Inc. (Solon, OH, USA). Streptomycin Mixture (100×), sucrose, glucose, and RIPA protein lysate were purchased from Beijing Solaibo Technology Co., Ltd. (Beijing, China). Sodium azide and dimethyl sulfoxide were obtained from Shanghai Sangong (Shanghai, China) and used as purchased. Human SH-SY5Y cell neuroblastoma was purchased from the Cell Center of the Peking Union Medical College (Beijing, China).