Brainpet insert

Manufactured by Siemens

Sourced in Germany

The BrainPET insert is a laboratory equipment designed for positron emission tomography (PET) imaging of the brain. It provides a specialized chamber to hold and position the subject during the scanning process.

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Lab products found in correlation

Tim trio, by Siemens (3 mentions) Tim trio 3 tesla, by Siemens (1 mentions) Magnetom trio mr scanner, by Siemens (1 mentions)

Close spelling variants of this product

BrainPET

7 protocols using brainpet insert

PET/MRI Imaging of Rhesus Macaques

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Male rhesus macaques were deprived of food for 12 h prior to the imaging study for the PET/MR scanning. Anesthesia was induced with intramuscular xylazine (0.5–2.0 mg/kg) and ketamine (10 mg/kg). The macaques were antecubital catheterized for radiotracer injection and a radial arterial line was placed for plasma and metabolite analysis. After endotracheal intubation, V-line and A-line were inserted, and the anesthetic state was maintained using isoflurane (∼1.5%) throughout the imaging studies. PET/MR images of the brain were acquired on a 3T Siemens TIM-Trio with a BrainPET insert (Siemens, Munich, Germany) and custom 8-channel head coil with an isotropic PET resolution of 1.25 mm at isocenter. Dynamic PET image acquisition was initiated, followed by the administration of [¹⁸F]PB118 (averaged dose: 5.07 mCi). A MEMPRAGE sequence was acquired 30 min after the start of the scan for anatomic co-registration. For the blocking experiments, macaque was pretreated with unlabeled PB118 (1.0 mg/kg) at 10 min before the radiotracer injection. Dynamic data from the PET scans were recorded in list mode and corrected for attenuation, scatter, and decay. Macaque data were reconstructed using a 3D-OSEM method into progressive longer time frames for data analysis. Reconstructed PET images were then converted to standard-update values (SUV) by dividing the injected dose and weight of the NHP.

Bai P., Mondal P., Bagdasarian F.A., Rani N., Liu Y., Gomm A., Tocci D.R., Choi S.H., Wey H.Y., Tanzi R.E., Zhang C, & Wang C. (2022). Development of a potential PET probe for HDAC6 imaging in Alzheimer's disease. Acta Pharmaceutica Sinica. B, 12(10), 3891-3904.

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Simultaneous MR/PET Imaging and Attenuation Correction

Cited 2 times

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Images were acquired during simultaneous MR/PET imaging on a TIM Trio 3 Tesla MR scanner with a BrainPET insert (Siemens Healthcare, Erlangen, Germany). MEMPRAGE (TR = 2350 ms, TE = 1.63/3.49/5.35/7.21 ms, flip angle 70⁰, 1 mm isotropic, 280x280x200 matrix) anatomical images were acquired for registration to a volume-based template (TT_N27) using AFNI (Cox, 1996 (link)) and cortical reconstruction and registration using FreeSurfer. These images were also used in the pseudo-CT procedure for attenuation correction. (Izquierdo-Garcia et al., 2014 (link); Ladefoged et al., 2017 (link))

Robinson M.E., McKee A.C., Salat D.H., Rasmusson A.M., Radigan L.J., Catana C., Milberg W.P, & McGlinchey R.E. (2019). Positron emission tomography of tau in Iraq and Afghanistan Veterans with blast neurotrauma. NeuroImage : Clinical, 21, 101651.

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Temozolomide and Bevacizumab for rGBM

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Patients with rGBM being treated with temozolomide 50 mg/m²/day and bevacizumab 10 mg/kg every 2 weeks were eligible to participate in this study. The dosing for temozolomide was based on the RESCUE study showing benefit of temozolomide rechallenge in a subset of patients (12 (link)). Patients with lower grade tumors that had progressed to GBM were eligible. All patients had to have radiographic evidence of tumor recurrence >2 months since completion of their last cycle of temozolomide or other alkylating agent and be >12 weeks from the completion of radiation. All patients signed informed consent and this trial was approved by the Dana-Farber Harvard Cancer Center Institutional Review Board (NCT01987830) in accordance with U.S. Common Rule. Patients underwent a baseline simultaneous PET-MRI scan (3T Siemens TimTrio with a BrainPET insert) after being on daily temozolomide for at least 5 consecutive days to minimize nonspecific temozolomide binding elsewhere in the body. The second PET-MRI visit was performed one day after the first bevacizumab infusion and the third PET-MRI one day prior to the third bevacizumab infusion (Supplementary Fig. S1).

Gerstner E.R., Emblem K.E., Chang K., Vakulenko-Lagun B., Yen Y.F., Beers A.L., Dietrich J., Plotkin S.R., Catana C., Hooker J.M., Duda D.G., Rosen B., Kalpathy-Cramer J., Jain R.K, & Batchelor T. (2019). Bevacizumab Reduces Permeability and Concurrent Temozolomide Delivery in a Subset of Patients with Recurrent Glioblastoma. Clinical cancer research : an official journal of the American Association for Cancer Research, 26(1), 206-212.

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Multimodal Neuroimaging with MRI and PET

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All studies involving human subjects were reviewed and approved by the Institutional Review Board (IRB) at Massachusetts General Hospital. All subjects provided written, informed consent in accordance with the Human Research Committee at Massachusetts General Hospital. The imaging studies were performed on a 3-T Tim MAGNETOM Trio MR scanner (Siemens Healthcare, Inc) with an MR-compatible BrainPET insert (Siemens). Three-dimensional (3D) coincidence event data were collected and stored in a list-mode format. Magnetic resonance imaging was performed using two concentric head coils: an outer circularly polarized transmit coil and an inner 8-channel receive-only coil specially designed for the BrainPET with considerations for 511 keV photon attenuation properties.

Villien M., Wey H.Y., Mandeville J.B., Catana C., Polimeni J.R., Sander C.Y., Zürcher N.R., Chonde D.B., Fowler J.S., Rosen B.R, & Hooker J.M. (2014). Dynamic Functional Imaging of Brain Glucose Utilization using fPET-FDG. NeuroImage, 100, 192-199.

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Multimodal Neuroimaging of Nonhuman Primates

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PET/MRI acquisition was performed on a 3T Siemens
TIM-Trio with a BrainPET insert (Siemens, Erlangen, Germany). A PET/MRI
compatible eight-channel array coil customized for nonhuman primate
brain imaging to increase image signal and quality was employed. After
administration of the radiotracer (5.2 mCi baseline, 2.9 mCi block),
dynamic PET image acquisition was initiated. Dynamic PET data were
collected and stored in list mode for 120 min. Image reconstruction
was performed using the 3D ordinary Poisson expectation maximization
algorithm with detector efficiency, decay, dead time, attenuation,
and scatter corrections. PET data were binned in 29 frames (6 ×
10 s, 6 × 20 s, 2 × 30 s, 1 × 1 min, 5 × 5 min,
9 × 10 min). Image volumes were eventually reconstructed into
76 slices with 128 × 128 pixels and a 2.5 mm isotropic voxel
size. Thirty minutes after scanner start, a high-resolution anatomical
scan using multiecho MPRAGE sequence (TR = 2530 ms, TE1/TE2/TE3/TE4
= 1.64/3.5/5.36/7.22 ms, TI = 1200 ms, flip angle = 7°, and 1
mm isotropic) was acquired.

Strebl M.G., Campbell A.J., Zhao W.N., Schroeder F.A., Riley M.M., Chindavong P.S., Morin T.M., Haggarty S.J., Wagner F.F., Ritter T, & Hooker J.M. (2017). HDAC6 Brain Mapping with [18F]Bavarostat Enabled by a Ru-Mediated Deoxyfluorination. ACS Central Science, 3(9), 1006-1014.

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PET/MRI Neuroimaging Protocols for Novel Radiotracers

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PET/MRI acquisition was performed on a 3T Siemens TIM-Trio with a BrainPET insert (Siemens, Erlangen, Germany). A PET/MRI compatible eight-channel array coil customized for nonhuman primate brain imaging to increase image signal and quality was employed. After administration of one of the radiotracers (1.4 mCi MGS1; 1.8 mCi MGS2; 0.55 mCi MGS3) or [¹¹C]Martinostat (4.9 mCi), dynamic PET image acquisition was initiated. Dynamic PET data were collected and stored in list mode for 90 min in the case of [¹¹C]Martinostat and 120 min for [¹⁸F]MGS1-3. Image reconstruction was performed using the 3D ordinary Poisson expectation maximization algorithm with detector efficiency, decay, dead time, attenuation, and scatter corrections. PET data were binned in 29 frames (6 × 10 s, 6 × 20 s, 2 × 30 s, 1 × 1 min, 5 × 5 min, 9x10 min for [¹⁸F] scans (6 × 10 min for [¹¹C]Martinostat)). Image volumes were eventually reconstructed into 76 slices with 128x128 pixels and a 2.5 mm isotropic voxel size. 30 minutes after scanner start, a high-resolution anatomical scan using multiecho MPRAGE sequence (TR = 2530 ms, TE1/TE2/TE3/TE4 = 1.64/3.5/5.36/7.22 ms, TI = 1200 ms, flip angle = 7°, and 1 mm isotropic) was acquired.

Strebl M.G., Wang C., Schroeder F.A., Placzek M.S., Wey H.Y., Van de Bittner G.C., Neelamegam R, & Hooker J.M. (2015). Development of a Fluorinated Class-I HDAC Radiotracer Reveals Key Chemical Determinants of Brain Penetrance. ACS chemical neuroscience, 7(5), 528-533.

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Quantitative 18F-FET PET Imaging

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The amino acid 18 F-FET was produced and applied as described previously (15) . All patients fasted for at least 12 h before the PET measurement and were injected intravenously with 3 MBq of 18 F-FET per kilogram of body weight. The dynamic 18 F-FET PET acquisition over 50 min was performed using a Siemens BrainPET insert (16) . The supplemental materials provide further details. All reconstructed frames (isotropic resolution, 1.25 mm) were smoothed with a 2.5-mm gaussian kernel, and motion was corrected using PMOD (version 3.5; PMOD Technologies LLC). The summed images from 20 to 40 min after injection were used for the analysis.

Mauler J., Lohmann P., Maudsley A.A., Sheriff S., Hoevels M., Meissner A.K., Hamisch C., Brunn A., Deckert M., Filss C.P., Stoffels G., Dammers J., Ruge M.I., Galldiks N., Mottaghy F.M., Langen K.J, & Shah N.J. (2024). Diagnostic Accuracy of MR Spectroscopic Imaging and ¹⁸F-FET PET for Identifying Glioma: A Biopsy-Controlled Hybrid PET/MRI Study. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 65(1).

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