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2 protocols using gabapentin d10

1

Quantitative Bioanalysis of Gabapentin and Buprenorphine

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Gabapentin, Gabapentin-D10, buprenorphine, buprenorphine-D4 were purchased from Sigma (St. Louis, MO) as solutions in methanol. LC-MS grade formic acid, ammonium acetate, methanol and acetonitrile were purchased from Fisher Scientific (Asheville, NC), and 0.22 μm PVDF centrifugal filters were purchased from Millipore (Billerica, MA). Human serum was purchased from Innovative Research (Novi, MI).
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2

Analytical Standards for Pharmaceuticals

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Analytical and isotopically labeled standards were all of high purity grade (>98%). Paracetamol (acetaminophen), metronidazole, codeine, morphine, sulfamethoxazol, ciprofloxacin, carbamazepine, metronidazole-hydroxyl, ibuprofen, piperacillin, diclofenac, mefenamic acidhydroxyl, Paracetamol-d4, morphine-d3, gabapentin-d10 and ibuprofen-d3 were purchased from Sigma-Aldrich (Buchs, Switzerland), sulfamethoxazol-d4 from LGC standards (Wesel, Germany) and gabapentin from Toronto Research Chemicals (Ontario, Canada). HPLC-grade methanol (MeOH) and acetonitrile (ACN), as well as HCl and formic acid were purchased from Sigma-Aldrich (Buchs, Switzerland). Ultrapure water (18.2 MΩ×cm) was obtained using a Millipore system (Millipore Ltd., Bedford, USA).
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