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264 protocols using fusion 360

1

3D-Printed Coil Source Support

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3D computer-aided design (CAD) models of the ESW cylindrical coil source support were designed using Autodesk Fusion 360 (Autodesk, Inc., San Rafael, CA, USA) to minimize the loss of ESW energy at the interface between head of the device and the 6-multiwells. The CAD data were exported in STL format for the 3D printer. A Ultimaker Creality Ender 3 printer, in its maximum resolution mode, was used for support printing using a polyvinyl chloride (PVC) material. The support printing process took approximately 24 h. The support is composed of two separate top (black, which adapts to the coil source size) and bottom (green, which keeps the support stable and suspended with respect to the 6-wellplates) parts (Figure 1).
Moreover, a mechanical simulation of the material used was conducted using Autodesk Fusion 360 (Autodesk, Inc., San Rafael, CA, USA) to assess the reply of the material to the solicitation given by the coil source and its minimal movement during the delivery of the shots. Results demonstrated a negligible deformation of the black part of the support (Figure 2).
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2

3D Knee Modeling from CT Scans

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For this study, a 3D model of the knee was obtained using CT images in Slicer3D (http://www.slicer.org) and 3D modeling with further processing was carried out using Autodesk ReCap Photo version 2019 and Autodesk Fusion360 (Autodesk, Inc.). Following the bone reconstruction, the menisci and cartilage tissue were modeled in Autodesk Fusion360 (Autodesk, Inc.) (Fig. 1).
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3D-Printed Prostate Molds for Histopathology

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Individually designed prostate molds were created for each patient to guide histopathology sectioning and to preserve the in-vivo shape and orientation of the specimen. A cubical shape was created in Fusion 360 (Autodesk, Inc. San Rafael, California, USA) (Fig. 1C). The cube had a standard volume of 6.6 × 6.6 × 6.6 cm3 and was constructed out of two separate parts that could be joined using a locking mechanism (Fig. 1D). Throughout the cube, eleven 1 mm thick slits were inserted (with 5 mm spacing), to be used for histopathology slicing. The exported RT-structs were converted into Standard Triangle Language (STL)-files using MICE toolkit (Nonpi Medical AB, Umeå, Sweden) [23] . The STL-files were imported into Meshmixer (Autodesk, Inc. San Rafael, California, USA) where they were smoothed and simplified by reducing the number of vertices (Fig. 1B) and subsequently used as inputs into Fusion 360 and subtracted from the cube. For each patient two molds were printed, with a margin of +1 mm and +2 mm, respectively, using MakerBot Replicator + 3D-printer (MakerBot Industries, Brooklyn, NY USA).
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3D Printing of Segmented Heart Models

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The segmented heart volumes were exported into Autodesk Fusion 360 (Autodesk, San Rafael, CA) and three mounting tabs were added to interface with the mounting apparatus as described below. The post-processed models were exported as stereolithography (STL) files that were 3D printed on a material jetting printer (J750, Stratasys, Eden Prairie, MN) in a rigid polycarbonate material (VeroVivid, Stratasys, Eden Prairie, MN). Figure 1 shows the pipeline from imaging to 3D printed models, and Figure 2 shows the heart models at various stages throughout this modeling process.
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5

3D Printed Cylindrical Printlets Design

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Autodesk Fusion 360 (ver. 2.0.9011, Autodesk Inc., San Rafael, CA, USA) was used to design the desired cylindrical printlets for each study. The 3D model was exported as a stereolithography file (.stl) into the 3D printing software, Slic3r (GNU Affero General Public License, ver. 3.0).
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6

Microdevice Fabrication Using Polycarbonate

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The design and toolpaths for the microdevice were created in Autodesk Fusion 360 (Autodesk, San Rafael, CA, USA) and were custom-milled (Shapeoko, Carbide 3D, Torrance, CA, USA) out of polycarbonate [26 (link)]. The final device was manufactured by pouring polydimethylsiloxane (PDMS) mixed in a 10:1 base to a curing agent ratio (Sylgard 184 elastomer kit; Dow Corning, Midland, MI, USA). PDMS was cured at 80 °C for 3 h, peeled off, and cut into individual devices. Channel inlets and outlets with 1.5 mm diameter were punched at both ends of microfluidic channels. The PDMS devices were permanently bound to the detergent-cleaned glass coverslips after plasma treatment for 50 s (Model PDC-001-HP, Harrick Plasma, Ithaca, NY, USA) for the subsequent lipid bilayer formation and substrate modification.
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7

Computational Modeling of Microfluidic Devices

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The devices were created in Autodesk Fusion 360 (Autodesk, San Rafael, CA, United States) with a single solid piece to model each device, with a second separate piece created to model the media inside of the channel and in the inlet and outlet. The material of the device was set to acrylic and the material of the fluid was set to water to approximate the actual material of our devices and the properties of our media. A boundary condition of the flow rate applied by the peristaltic pump was set to the inlet and default settings were used to generate the mesh before the model was solved for the shear stress and visualized.
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8

Tailored Dosage Forms via 3D Printing

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In the previous study [26 (link)], seven different sizes were designed and printed to show the printer’s capability to produce tailored doses. The correlation between designed size and obtained dry weight and between obtained wet weight and obtained dry weight were R2 = 0.9966 and R2 = 0.9998, respectively [26 (link)]. The study demonstrated that the prepared formulation and the printing technology were suitable for producing tailored drug doses. In the current study, four different sizes were considered sufficient to show the correlation between the pre-determined design and the obtained drug amount in the printed dosage form. The four different sized rectangles were designed utilizing a computer-aided design (CAD) software (Autodesk Fusion 360 by Autodesk, San Rafael, CA, USA, 2.0.10446, 2020). The designed rectangles had the same width and height of 10 and 1 mm, respectively, but they were designed with increasing lengths (5, 10, 15, and 20 mm) and were named according to their length.
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9

3D Printing of PCL Constructs

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PCL constructs (films and scaffolds) were designed using the computer-aided design (CAD) software Autodesk Fusion 360 (version up to 2.0.11415, Autodesk, Inc., San Francisco, CA, USA). The models designed were exported as STL files by FDM to a Prusa i3 MK3S commercial 3D printer (Prusa Research, Praha, Czech Republic). Slicing of the STL files into G-code was done in PrusaSlicer 2.3.1 (Prusa Research). For 3D printing, nozzle (brass, 0.25 mm in diameter -Prusa Research) and bed temperatures were set to 95 1C and 40 1C, respectively. The layer height was defined as 0.15 mm for all layers, and the default ''Quality'' profile was adopted for printing.
The designed PCL film was shaped as a 20 mm  10 mm  0.5 mm cuboid. To fill any gaps and ensure a smooth first layer, the first layer was modified to be printed with a 0.15 mm extrusion width and using a 1.2 extrusion multiplier.
For the PCL scaffold design, an orthogonal pattern with aligned fibers was chosen (0-901 rotations between successive layers). The pore size of the scaffold and fiber diameter were both specified to have a dimension of 300 mm. The overall scaffold size was 10.5 mm  10.5 mm  3 mm. Since each scaffold layer had a height of 0.30 mm with the defined printing layer height of 0.15 mm, two printing passages were necessary to print each scaffold layer.
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10

Evaluating AGP-File Compatibility Using 3D Models

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Based on the mean diameters obtained from each AGP model, 3D point models were designed with Autodesk® Fusion 360 (Autodesk Inc., Mill Valley, CA, USA). Similarly, 3D models of each file selected for this study were designed based on the tip and taper values provided by their respective manufacturers. The 3D models of the points and files were overlapped in the software, generating all possible combinations; this enabled an examination of whether the 3D point shapes matched the shapes of the files to determine compatibility. To be considered compatible, the AGP taper had to be the same size or smaller than the instrument, with a maximum difference of 0.005 mm, while the AGP tip also had to be the same size or smaller than the instrument, but with a maximum difference of 0.05 mm.
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