Cd2cl2

Manufactured by Cambridge Isotopes

Sourced in United States

CD2Cl2, or dichloromethane-d2, is a deuterated solvent commonly used in nuclear magnetic resonance (NMR) spectroscopy. It is a colorless, volatile liquid with a chloroform-like odor. CD2Cl2 is a deuterium-labeled version of dichloromethane, which is widely used as a solvent in various applications.

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Lab products found in correlation

Cdcl3, by Cambridge Isotopes (3 mentions) Cd3cn, by Cambridge Isotopes (2 mentions) 400 mhz spectrometer, by Bruker (2 mentions) Pmdeta, by Merck Group (1 mentions) Anhydrous methanol, by Thermo Fisher Scientific (1 mentions) Alexa fluor 488 azide, by Thermo Fisher Scientific (1 mentions) 2 2 dimethoxy 2 phenylacetophenone dmpa, by Merck Group (1 mentions) Dmso d6, by Cambridge Isotopes (1 mentions) Copper bromide cubr, by Merck Group (1 mentions) Cyclohexene, by Merck Group (1 mentions) Trioctylphosphine, by Merck Group (1 mentions) 300 mhz instrument, by Agilent Technologies (1 mentions) Deuterated solvents for nmr spectroscopy, by Cambridge Isotopes (1 mentions) 1 4 cyclohexadiene, by Merck Group (1 mentions) Ch2cl2, by Thermo Fisher Scientific (1 mentions) Ch2cl2, by MBraun (1 mentions) Tetrahydrofuran thf, by Thermo Fisher Scientific (1 mentions) L α phosphatidylcholine pc, by Avanti Polar Lipids (1 mentions) Polycarbonate membrane, by Merck Group (1 mentions)

9 protocols using cd2cl2

Solvent Purification and Chemical Reagents

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Dichloromethane, tetrahydrofuran (THF), and N,N-dimethylformamide (DMF) were purified
by passage through a solvent purification system (JC Meyer Solvent
Systems) and used as anhydrous solvents. The deuterated solvents (CDCl₃, CD₂Cl₂, DMSO-d₆) were products of Cambridge Isotopes Laboratories. All other
reagents and solvents, tributylphosphine (PBu₃, Alpha Aesar),
trimethylphosphine (PMe₃, Alpha Aesar), 2-chloroethanol
(Alpha Aesar), thionyl chloride (SOCl₂, Aldrich), potassium
thioacetate (KSAc, Alpha Aesar), anhydrous methanol (Alpha Aesar),
2,2-dimethoxy-2-phenylacetophenone (DMPA, Aldrich), anhydrous dimethyl
sulfoxide (ACROS, DMSO), Alexa Fluor 488 azide (A488, Life Technologies),
copper bromide (CuBr, Aldrich), N,N,N′,N′,N″-pentamethyldiethylenetriamine (PMDETA, Aldrich), and ultrapure
water (molecular biology grade, Quality Biological, Inc.) were used
as received.

Borguet Y.P., Khan S., Noel A., Gunsten S.P., Brody S.L., Elsabahy M, & Wooley K.L. (2018). Development of Fully Degradable Phosphonium-Functionalized Amphiphilic Diblock Copolymers for Nucleic Acids Delivery. Biomacromolecules, 19(4), 1212-1222.

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Deoxygenation and Purification Protocols

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All commercially obtained reagents were used
as received unless otherwise noted. All solvents were stored in a
≤1 ppm O₂ drybox prior to use. Acetone packed under
nitrogen was purchased from Burdick & Jackson (water content <0.5%).
Cyclohexene (Aldrich, 99%) was freshly distilled over sodium metal
under argon and stored in a predried glass bottle. [Ir(1,5-COD)Cl]₂ (STREM), tris(dodecyl)amine (Aldrich, 97%), trioctylphosphine
(Aldrich, 97%), and tributylamine (Aldrich, ≥99.5%) were stored
in a drybox. Solutions (1.0 M) of proton sponge (Aldrich) in acetone
were freshly made. Acidic γ-Al₂O₃ (Aldrich)
with a surface area of 155 m²/g was dried at 160 °C
for 24 h and stored in the drybox prior to use. CD₂Cl₂ (Cambridge Isotope Laboratories) from 1 mL glass ampoules
were transferred into the drybox for NMR sample preparation. H₂ gas was purchased from General Air in >99.5% purity and
passed
through O₂ and H₂O scavenging traps (Trigon
Technologies) before use to pressurize Fisher-Porter (FP) bottle reactors
(vide infra).

Mondloch J.E., Özkar S, & Finke R.G. (2018). “Weakly Ligated, Labile Ligand” Nanoparticles: The Case of Ir(0)n·(H+Cl–)m. ACS Omega, 3(11), 14538-14550.

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Synthesis of Lanthanide-Manganese Compounds

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Reactions performed under an inert atmosphere were carried out in oven-dried glassware in a glovebox under a nitrogen atmosphere. Anhydrous dichloromethane and diethyl ether were purified by sparging with nitrogen for 15 min and then passing under nitrogen pressure through a column of activated A2 alumina (Zapp’s). CD₂Cl₂ was purchased from Cambridge Isotope Laboratories, dried over calcium hydride, then degassed by three freeze–pump–thaw cycles, and vacuum-transferred prior to use. ¹H NMR spectra were recorded on a Varian 300 MHz instrument, with shifts reported relative to the residual solvent peak. ¹⁹F NMR spectra were recorded on a Varian 300 MHz instrument, with shifts reported relative to the internal lock signal. Elemental analyses were performed by Robertson Microlit Laboratories. All commercial chemicals were used as received. Dysprosium trifluoromethanesulfonate (Dy(OTf)₃) and decamethylferrocene were purchased from Strem, and yttrium trifluoromethanesulfonate (Y-(OTf)₃) was purchased from Aldrich. [LDyMn₃O₄(OAc)₃(DMF)₂]-[OTf]^{5b (link)} and [LYMn₃O₄(OAc)₃(DMF)₂][OTf]^{5c (link)} were prepared according to previously published procedures.

Lin P.H., Tsui E.Y., Habib F., Murugesu M, & Agapie T. (2016). Effect of the Mn Oxidation State on Single-Molecule-Magnet Properties: MnIII vs MnIV in Biologically Inspired DyMn3O4 Cubanes. Inorganic chemistry, 55(12), 6095-6099.

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Inert Atmosphere Synthesis and Characterization

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All air- and moisture-sensitive
manipulations were carried out using a standard high vacuum line,
Schlenk, or cannula techniques or in an MBraun inert atmosphere drybox
containing an atmosphere of purified dinitrogen. All solids were dried
under a high vacuum in order to be brought into the glovebox. Solvents
for air- and moisture-sensitive manipulations were dried and deoxygenated
using a Glass Contour Solvent Purification System (Pure Process Technology,
LLC) and stored over activated 4 Å molecular sieves (Fisher Scientific)
prior to use. Deuterated solvents for NMR spectroscopy were purchased
from Cambridge Isotope Laboratories, distilled from sodium metal (C₆D₆) or CaH₂ (CD₂Cl₂) after three freeze–pump–thaw cycles, and stored in
the glovebox over activated 3 Å molecular sieves. Uranyl chloride
trihydrate was purchased from International Bio-Analytical Industries
and used as received. All the remaining chemicals were purchased from
commercial sources (Fisher Scientific, VWR, and Sigma-Aldrich) and
used without further purification. H₂^MesPDP^Ph,^{60 (link)} H₂^Cl2PhPDP^Ph,^{62 (link)} and [UO₂Cl₂(THF)₂]₂^{75 (link)} were synthesized following reported procedures.

Hakey B.M., Leary D.C., Lopez L.M., Valerio L.R., Brennessel W.W., Milsmann C, & Matson E.M. (2022). Synthesis and Characterization of Pyridine Dipyrrolide Uranyl Complexes. Inorganic Chemistry, 61(16), 6182-6192.

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Synthesis and Characterization of Mn(V) Complex

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The compound Mn^V(O)(TBP₈Cz) was synthesized according to a published procedure.^{24 (link)} All other reagents were commercially available and purchased at the highest level of purity and used as received unless otherwise specified here. The oxonium acid HBAr^F ([H(OEt₂)₂]⁺[B(C₆F₅)₄]⁻) was synthesized according to a published procedure.⁵² The substrate 9,10-dihydro-10-methylacridine (AcrH₂) was synthesized according to a published procedure.^{41 (link)} The substrates xanthene (Xn) and 9,10-dihydroanthracene (DHA) were purchased from Sigma-Aldrich and recrystallized at least three times from ethanol. The substrate 1,4-cyclohexadiene (CHD) was purchased from Sigma-Aldrich and purified by running through an alumina pipette column immediately before use. The deuterated substrate xanthene-d₂ was synthesized according to a published procedure.^{53 (link)} Deuterated solvents (CDCl₃ and CD₂Cl₂) for NMR were purchased from Cambridge Isotopes, Inc.

Baglia R.A., Krest C.M., Yang T., Leeladee P, & Goldberg D.P. (2016). High-Valent Manganese-Oxo Valence Tautomers and the Influence of Lewis/Brönsted Acids on C−H Bond Cleavage. Inorganic chemistry, 55(20), 10800-10809.

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Synthesis of Heterobimetallic Complexes

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The
heterobimetallic complexes, [ClNi(o-Ph₂P-C₆H₄)₃As]Cl,^{31 (link)} ClNi(o-Ph₂P-C₆H₄)₃SbCl,^{32 (link)} ClAu(o-iPr₂P-C₆H₄)₂BiCl,^{33 (link)} ClPt(o-Ph₂P-C₆H₄)₃SbCl,^{34 (link)} and ClPd(o-Ph₂P-C₆H₄)₂SbCl₂,^{35 (link)} were prepared according to literature procedures.
[(CyNC)Pd(o-Ph₂P-C₆H₄)₂SbCl₂][SbF₆] and [ClPd(o-Ph₂P-C₆H₄)₃As]Cl are synthesized as follows. NiCl₂ (anhydrous, 98%),
bis(1,5-cyclooctadiene)nickel (0) (Ni(COD)₂, 98+%), Ph₃Sb (97%), cyclohexyl isocyanide (CyNC, 98%), and AgSbF₆ (99%) were purchased from Strem and used as received. CH₂Cl₂, Et₂O, and tetrahydrofuran (THF)
were purchased from Fisher Chemical, and celite was purchased from
MilliporeSigma. CD₂Cl₂ and CDCl₃ were
purchased from Cambridge Isotope Labs and used as received. CH₂Cl₂ was dried over alumina using a column-based
solvent purification system from MBraun. Et₂O and THF were
refluxed under N₂ over Na/K and distilled prior to use.
All precursor syntheses were carried out in air.

Daniels C.L., Mendivelso-Perez D.L., Rosales B.A., You D., Sahu S., Jones J.S., Smith E.A., Gabbaï F.P, & Vela J. (2019). Heterobimetallic Single-Source Precursors: A Springboard to the Synthesis of Binary Intermetallics. ACS Omega, 4(3), 5197-5203.

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Synthesis and Characterization of Glycine Polymers

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All the chemicals and solvents were purchased
from Sigma Aldrich and were used as received unless otherwise noted.
The solvents used for polymerization were further purified by using
alumina columns under argon protection. CD₂Cl₂ and CDCl₃ were purchased from Cambridge Isotope laboratories. l-α-Phosphatidylcholine (PC) and liposome extrusion setup
were purchased from Avanti Polar Lipids. Polycarbonate membranes and
membrane filter support were purchased from EMD Millipore. Deionized
water used for DLS and SLS was further purified by a Nanopure Bioresearch
water purification system with a resistance of 17.8–17.9 MΩ·cm
from Barnstead Lab Water Products. ¹H NMR was collected
by a Bruker AV-400 III spectrometer at 298 K and analyzed using Topspin
software. Chemical shifts (δ) given in parts per million (ppm)
were referenced to protio impurities. N-Decyl glycine-derived N-carboxyanhydride (De-NCA), N-butyl glycine-derived N-carboxyanhydride (Bu-NCA), and N-methoxyethyl
glycine-derived N-carboxyanhydride (MeOEt-NCA) monomers
were synthesized using a published procedure.^{34 (link)}

Yu T., Omarova M., Zhang M., Hossain I., Chen J., Darvish O., John V.T, & Zhang D. (2023). Uncovering the Optimal Molecular Characteristics of Hydrophobe-Containing Polypeptoids to Induce Liposome or Cell Membrane Fragmentation. Biomacromolecules, 24(3), 1511-1521.

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Inert Atmosphere Synthesis and NMR Characterization

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All manipulations were carried out in dry N2-filled gloveboxes (Vacuum Atmospheres Co., Hawthorne, CA) or under N2 atmosphere using standard Schlenk techniques unless otherwise noted. All solvents were of commercial grade and dried over activated alumina using a PPT Glass Contour (Nashua, NH) solvent purification system prior to use, and were stored over molecular sieves. All chemicals were from major commercial suppliers and used as received or after extensive drying. CD3CN and CD2Cl2 were purchased from Cambridge Isotope Laboratories (Tewksbury, MA, USA) and dried over 3 Å molecular sieves. 1 H, 13 C, 31 P and 19 F NMR spectra were collected on a 400 MHz Bruker spectrometer (Bruker, Billerica, MA, USA) and referenced to the residual protio-solvent signal 41 in the case of 1 H and 13 C. 31 P and 19 F NMR spectra were referenced and reported relative to H3PO4 and CCl3F, respectively, as external standards following the recommended scale based on ratios of absolute frequencies (Ξ). 42, 43 Chemical shifts (δ) are reported in units of ppm and coupling constants (J) are reported in Hz. All experiments were conducted at room temperature (298 K).

Kumar A, & Blakemore J.D. (2021). On the Use of Aqueous Metal-Aqua pK_a Values as a Descriptor of Lewis Acidity. Inorganic chemistry, 60(2).

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Inert Atmosphere Synthesis and NMR Characterization

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Kumar A., & Blakemore J.D. (2020). On the Use of Aqueous Metal-Aqua pKa Values as a Descriptor of Lewis Acidity.

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