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Virtual optometry system

Manufactured by Cerebral Mechanics
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Sourced in Canada

The Virtual Optometry System is a laboratory equipment designed to simulate various eye conditions and visual impairments. It allows for the evaluation and assessment of visual function under controlled settings.

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3 protocols using virtual optometry system

1

Assessing Mouse Visual Acuity using Virtual Optometry

Cited 4 times
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Mouse visual acuity (VA) was assessed using the Virtual Optometry System (Optometry, Cerebral Mechanics, Inc., Canada). Briefly, the virtual rotating columns were projected on the LCD monitors with different spatial frequencies in cycles/degree (c/d). The mouse head movement in response to the rotating virtual columns was noted. The VA was defined as the highest spatial frequency the mouse was able to respond to the virtual rotating columns. The spatial frequency was changed starting from 0.1 c/d with a step size of 0.05 c/d until the mouse stopped responding. When VA ≤ 0.25 c/d, the mouse was considered to develop impaired VA, as defined by previous studies (26 (link), 27 (link), 34 (link), 35 (link)). VA was performed right before each in vivo MRI scan session.
Yang H.C., Lavadi R.S., Sauerbeck A.D., Wallendorf M., Kummer T.T., Song S.K, & Lin T.H. (2023). Diffusion basis spectrum imaging detects subclinical traumatic optic neuropathy in a closed-head impact mouse model of traumatic brain injury. Frontiers in Neurology, 14, 1269817.
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2

Evaluation of Visual Acuity in MOG-Induced EAE

Cited 3 times
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Mouse VA was assessed using the Virtual Optometry System (OptoMotry, Cerebral Mechanics, Inc., Canada). Briefly, the virtual rotating columns were projected on the LCD monitors with different spatial frequencies in cycles/degree (c/d). The mouse head movement in response to the virtual column rotations was noted. The spatial frequency was starting from 0.1 c/d with step size of 0.05 c/d until the mouse stopped responding. The VA was defined as the highest spatial frequency to which the mouse responded to the virtual rotating columns. Each mouse was confirmed to have normal VA before immunization. After immunization, daily VA was assessed until VA ≤ 0.25 c/d, our definition for the onset of ON in MOG35–55 EAE mice (Chiang et al., 2014 (link); Lin et al., 2014a (link),b (link)). The first day of VA ≤ 0.25 c/d both Dex- and PBS-treated group was 13.4 ± 3.7 days post immunization. Upon Dex treatment commencement, VA was performed twice a week and 1 day before MRI scans.
Lin T.H., Zhan J., Song C., Wallendorf M., Sun P., Niu X., Yang R., Cross A.H, & Song S.K. (2021). Diffusion Basis Spectrum Imaging Detects Axonal Loss After Transient Dexamethasone Treatment in Optic Neuritis Mice. Frontiers in Neuroscience, 14, 592063.
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3

Visual Acuity Measurement and MEMRI in EAE Mice

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The VA of mice was measured daily starting before immunization using the Virtual Optometry System (Optomotry, Cerebral Mechanics, Inc., Canada). Briefly, the virtual rotating columns were projected on the LCD monitors with different spatial frequencies in cycles/degree (c/d). The mouse head movement in response to the virtual column rotations was noted. The spatial frequency was increased starting from 0.1 c/d with step size of 0.05 c/d until the mouse stopped responding. The VA was defined as the highest spatial frequency of the virtual rotating columns to which the mouse was able to respond. We have previously reported that VA of normal C57BL/6 mice to be 0.38 ± 0.03 c/d (mean ± SD, n=30) and defined VA ≤ 0.25 c/d as the onset of acute ON for EAE mice (Chiang et al., 2012 ). MEMRI was performed on the day when mice exhibited VA ≤ 0.25 c/d. The mice in sham group did not develop impaired visual function and underwent the same MEMRI procedure at the same day as EAE group.
Lin T.H., Kim J.H., Perez-Torres C., Chiang C.W., Trinkaus K., Cross A.H, & Song S.K. (2014). Axonal transport rate decreased at the onset of optic neuritis in EAE mice. NeuroImage, 100, 244-253.
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