3-NP, dimethyl sulfoxide (DMSO), and carboxymethyl cellulose (CMC) were procured from Sigma-Aldrich, St. Louis, MD, USA. Telmisartan (Micardis®) was purchased from Boehringer Ingelheim, Germany. Pioglitazone (Actos®) was purchased from Takeda Pharmaceuticals Ltd. The PPARγ antagonist, GW9662, was purchased from MedChemExpress, NJ, USA. All other chemicals and reagents used in this study were of analytical grade.
Micardis
Manufactured by Boehringer Ingelheim
Sourced in Germany
Micardis is an angiotensin II receptor blocker (ARB) used to treat high blood pressure. It works by relaxing blood vessels to lower blood pressure.
Automatically generated - may contain errors
Lab products found in correlation
Carboxymethylcellulose, by Merck Group (1 mentions)
Gw9662, by MedChemExpress (1 mentions)
Sodium hydroxide (naoh), by Thermo Fisher Scientific (1 mentions)
Methanol, by Thermo Fisher Scientific (1 mentions)
Sodium acetate, by Thermo Fisher Scientific (1 mentions)
Telmisartan, by Tokyo Chemical Industry (1 mentions)
Potassium dihydrogen phosphate, by Scharlab (1 mentions)
Glacial acetic acid, by Thermo Fisher Scientific (1 mentions)
6 protocols using micardis
1
Investigating Pharmacological Modulators
2
TELM Modulation of Periodontal Inflammation
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Animals were treated with TELM; 10 mg/kg (Micardis®; Boehringer Ingelheim, São Paulo, Brazil) dissolved in phosphate-buffered saline (vehicle), administered by oral gavage once daily for 15 days, beginning 1 day before PD induction. As the study main goal was to evaluate the local RAS role in the inflammation-induced bone alteration, drug treatment protocol was based on literature evidences of the anti-hypertensive effectiveness and anti-inflammatory properties in the periodontium of 10 mg/kg TELM in the rodent model (Wienen et al., 2001 (link); Araújo et al., 2013 (link)).
3
Telmisartan Therapy in NASH Mice
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Eight NASH mice were orally administered the vehicle supplemented with telmisartan at a dose of 10 mg/kg once daily from 6 to 9 weeks of age.
Telmisartan, which has been reported to have antisteatotic, anti-inflammatory, and antifibrotic effects in STAM model, was used as the positive comparator.
AFO-202 and N-163 beta-glucan were provided by GN Corporation Co Ltd. Telmisartan (Micardis®) was purchased from Boehringer Ingelheim GmbH (Germany).
Telmisartan, which has been reported to have antisteatotic, anti-inflammatory, and antifibrotic effects in STAM model, was used as the positive comparator.
AFO-202 and N-163 beta-glucan were provided by GN Corporation Co Ltd. Telmisartan (Micardis®) was purchased from Boehringer Ingelheim GmbH (Germany).
4
Comparative Analysis of Telmisartan Tablets
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Eight brands of Telmisartan tablets (40 mg) were purchased from a local pharmacy: Micardis® (Boehringer Ingelheim, Sydney, Australia), DRLA® (Dr Reddy’s Laboratories, Melbourne, Australia), APO® (Apotex, Sydney, Australia), Mizart® (Alphapharm, Ipswich, Australia), GH® (Generic Health, Melbourne, Australia), Teltartan® (Arrow Pharma, Melbourne, Australia), Sandoz® (Sandoz, Sydney, Australia), and Pharmacor® (Pharmacor, Sydney, Australia). All tablets were tested within their original expiry periods, and where chemical analyses were performed, tablets with the same batch number were used. Webster-pak® 28 (Webstercare, Sydney, Australia) medication packs (small, heat-sealed) were employed for tablet repackaging.
Telmisartan of 99.8% purity from Tokyo Chemical Industry (Tokyo, Japan) was used for high performance liquid chromatography (HPLC) standard. Methanol (Fisher, Geel, Belgium; HPLC Grade), sodium hydroxide (Ajax Finechem, Sydney, Australia; analytical reagent), sodium acetate (Ajax Finechem, Sydney, Australia; analytical reagent), glacial acetic acid (Ajax Finechem, Sydney Australia; analytical reagent), and potassium dihydrogen phosphate (Scharlau, Sentmenat, Spain; reagent grade) were used to prepare HPLC mobile phase and buffers.
Telmisartan of 99.8% purity from Tokyo Chemical Industry (Tokyo, Japan) was used for high performance liquid chromatography (HPLC) standard. Methanol (Fisher, Geel, Belgium; HPLC Grade), sodium hydroxide (Ajax Finechem, Sydney, Australia; analytical reagent), sodium acetate (Ajax Finechem, Sydney, Australia; analytical reagent), glacial acetic acid (Ajax Finechem, Sydney Australia; analytical reagent), and potassium dihydrogen phosphate (Scharlau, Sentmenat, Spain; reagent grade) were used to prepare HPLC mobile phase and buffers.
5
Bioavailability Assessment of Telmisartan/S-Amlodipine FDC
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The test medication was 40 mg telmisartan/5 mg S-amlodipine FDC tablets (Chong Kun Dang Pharmaceutical Corp., Seoul, Republic of Korea), and the reference tablets were 40 mg of telmisartan (Micardis®; Boehringer Ingelheim, Ingelheim, Germany) and 5 mg of S-amlodipine (Anidipine S®; Chong Kun Dang Pharmaceutical Corp.).
6
Synthesis and Characterization of Bioactive Lipid Compounds
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The bioactive compounds VB-201 [(R)-1-hexadecyl-2-(4-carboxy)butyl-sn-glycero-3-phosphocholine] and VB-703 [1-(2-octyl)dodecyl-2-(4′-carboxy)butyl-glycero-sn-3-phosphoric acid pyridiniumethyl ester] (Fig. 1 ) were synthesized in VBL’s chemical laboratory (Or Yehuda, Israel). The generation of VB-201 was described previously [20 (link)]. VB-703 was synthesized from (S)-1-(2-octyl)dodecyl-2-(4′-carboxy)butyl-glycerol. The free acid was protected by esterification and reacted with phosphorus oxychloride followed by the addition of O-tosyl ethylene glycol. After aqueous hydrolysis, 1-(2-octyl)dodecyl-2-(4′-carboxy)butyl-glycero-sn-3-phosphoric acid tosylethyl ester was obtained. Heating of 1-(2-octyl)dodecyl-2-(4′-carboxy)butyl-glycero-sn-3-phosphoric acid tosylethyl ester in pyridine and purification by chromatography over silica gel yielded 1-(2-octyl)dodecyl-2-(4′-carboxy)butyl-glycero-sn-3-phosphoric acid pyridiniumethyl ester (VB-703). To prepare dosing solutions, VB-201 and VB-703 were dissolved in the solvent (0.5 % ethanol in PBS). Telmisartan (Micardis®) was purchased from Boehringer Ingelheim GmbH (Germany) and was dissolved in pure water.![]()
Chemical structures of VB-201 and VB-703
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