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α helical crf9 41

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α-helical CRF9–41 is a synthetic peptide that corresponds to the sequence of the C-terminal region of the corticotropin-releasing factor (CRF) protein, specifically residues 9 to 41. This peptide is often used in research applications to study the functional properties and interactions of the CRF protein.

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Lab products found in correlation

Antalarmin hydrochloride, by Bio-Techne (1 mentions) Isothesia, by Henry Schein (1 mentions) Antisauvagine 30, by Bio-Techne (1 mentions)

2 protocols using α helical crf9 41

1

Chronic Modulation of CRHR Signaling in Mice

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Osmotic minipumps (ALZET®, Model 1002, Charles River) were implanted subcutaneously into pregnant or non-pregnant mice to chronically administer test agents. Surgical implantation of osmotic minipumps was carried out on day 7 of pregnancy (or equivalent time interval for non-pregnant mice) under isoflurane anaesthesia (Isothesia®, Henry Schein®). Minipumps were loaded with physiological saline, non-specific CRHR antagonist (α-helical CRF9–41, 1 mg/ml, Tocris) or receptor-specific CRHR antagonists, antalarmin hydrochloride (1 mg/mL, Tocris) or antisauvagine-30 (3 mg/mL, Tocris) for CRHR1 and R2, respectively. Test agents were delivered at a rate of 0.25 µL/h for a total period of 11 days. Assessment of glucose tolerance and insulin tolerance were conducted on gestational days 16 and 18, respectively.
Simpson S.J., Smith L.I., Jones P.M, & Bowe J.E. (2020). UCN2: a new candidate influencing pancreatic β-cell adaptations in pregnancy. The Journal of Endocrinology, 245(2), 247-257.
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2

CRF Modulation of Fear Extinction

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15 min prior to fear extinction learning, animals received bilateral intra-BLA infusions of vehicle (saline, 0.5μL), one of two doses of the CRF-BP inhibitor rat/human CRF(6–33) dissolved in vehicle (0.1μg/side or 1.0μg/side in 0.5μL; Tocris Bioscience) or CRF dissolved in vehicle (15 ng/side in 0.5μL; Tocris Bioscience) or the non-selective CRF receptor antagonist α-helical CRF(9-41) (1μg/side in 0.5μL vehicle; Tocris Bioscience). Animals were infused at a rate of 1 μL/min and the infusion cannulas (extending 2 mmfrom the guide cannulas) were left in place for 1–2 min to allow drug diffusion away from the tip.
Abiri D., Douglas C.E., Calakos K.C., Barbayannis G., Roberts A, & Bauer E.P. (2014). Fear extinction learning can be impaired or enhanced by modulation of the CRF system in the basolateral nucleus of the amygdala. Behavioural brain research, 271, 234-239.
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