Trihexyphenidyl, atropine, nicotine, neostigmine, ʟ -DOPA, and dopamine were obtained from Sigma-Aldrich (St. Louis, MO). Dihydro-β-erythroidine (DHβE), ambenonium, and CNQX were obtained from Tocris (Minneapolis, MN).
Trihexyphenidyl
Manufactured by Merck Group
Sourced in Japan
Trihexyphenidyl is a medication that functions as an anticholinergic agent. It is used to treat symptoms associated with Parkinson's disease and other movement disorders.
Automatically generated - may contain errors
Lab products found in correlation
2 protocols using trihexyphenidyl
1
Neurotransmitter Modulation Protocol
2
Pharmacological Modulation of Tremor in Rats
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TRM rats (5–7 weeks of age) were given the β receptor antagonist propranolol (30 mg/kg i.p.; Sigma-Aldrich, St. Louis, MO, USA), GABAA receptor stimulant phenobarbital (Phenobal, 20 mg/kg i.p.; Daiichi Sankyo Co. Ltd., Tokyo, Japan) or muscarinic acetylcholine receptor antagonist trihexyphenidyl (3 mg/kg i.p.; Sigma-Aldrich) and placed individually in an observation box (25 × 42 × 20 cm). Tremor duration and intensity were estimated in each 1-min observation period, immediately before and 15, 30, 45 and 60 min after drug administration. The tremor intensity was evaluated using a four-point ranked scale (0, none; 1, weak; 2, moderate; 3, marked). Recording of electromyograph (EMG) activity was conducted under freely moving conditions, as described previously [19 (link)].
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