Nai scintillation detector

Manufactured by Bioscan

The NaI scintillation detector is a radiation detection device that utilizes a sodium iodide (NaI) crystal to convert incident radiation into visible light. This detector is designed to measure the energy and intensity of various types of radiation, including gamma rays and X-rays. The NaI crystal is coupled with a photomultiplier tube, which converts the light pulses into electrical signals that can be analyzed and processed.

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3 protocols using nai scintillation detector

11C-MET Purity and Identity Analysis

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Chemical purity, radiochemical purity and radiochemical identity of ¹¹C–MET and by-products were determined using an Agilent (Santa Clara, CA) HPLC system equipped with a model 1200 quaternary pump, a model 1200 UV absorbance detector (set at 220 nm), and a Bioscan (Washington, DC) NaI scintillation detector. The operation of the Agilent HPLC system was controlled using the Agilent ChemStation software. The HPLC column used was a Phenomenex Luna C18 analytical column (5 μ, 250 × 4.6 mm). The HPLC solvent was phosphate buffer (1 mM, pH 3), and the flow rate was 1.0 mL/min.

Woods M., Leung L., Frantzen K., Garrick J.G., Zhang Z., Zhang C., English W., Wilson D., Bénard F, & Lin K.S. (2017). Improving the stability of 11C–labeled L-methionine with ascorbate. EJNMMI Radiopharmacy and Chemistry, 2, 13.

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Radiolabeling of Compounds with Iodine-123

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[¹²³I] NaI was purchased from Nordion. (S)-1,2-isopropyilideneglycerol, 4-(dimethylamino)pyridine, pyridine, N,N-dimethylformamide, p-tolunesulfonyl chloride, bisphenol A, sodium iodide, sodium perchlorate, sodium hydroxide, HPLC grade methanol, sodium hydride, (2R)-glycidyl tosylate, cerium chloride heptahydrate, HPLC grade acetonitrile, phosphate buffer, and chloramine-T were purchased from Sigma Aldrich. Purification and quality control of ¹²³I-labeled compounds were performed on an Agilent HPLC System equipped with a model 1200 quaternary pump, a model 1200 UV absorbance detector (set at 220 nm), and a Bioscan NaI scintillation detector. The radiodetector was connected to a Bioscan B-FC-1000 Flow-count System, and the output from the Bioscan Flow-count system was fed into an Agilent 35900E Interface, which converted the analog signal to digital signal. The operation of the Agilent HPLC System was controlled using the Agilent ChemStation software. The HPLC columns used were a semipreparative column (Phenomenex Luna C18, 5 μ, 250 × 10 mm) and an analytical column (Phenomenex Luna C18, 5 μ, 250 × 4.6 mm). Radioactivity of ¹²³I-labeled compounds was measured using a Capintec CRC-25R/W dose calibrator. Details are available in the Supplemental Experimental Procedures.

Imamura Y., Tien A.H., Pan J., Leung J.K., Banuelos C.A., Jian K., Wang J., Mawji N.R., Fernandez J.G., Lin K.S., Andersen R.J, & Sadar M.D. (2016). An imaging agent to detect androgen receptor and its active splice variants in prostate cancer. JCI Insight, 1(11), e87850.

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Radiolabeling of Bombesin Peptides

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All reagents and
solvents were purchased
from commercial sources and used without further purification. [d-Phe⁶,Leu-NHEt¹³,des-Met¹⁴]bombesin(6-14) and bombesin were purchased from Bachem and AnaSpec,
respectively. Other peptides were synthesized on an AAPPTec Endeavor
90 peptide synthesizer. HPLC was performed on an Agilent 1260 infinity
system (model 1200 quaternary pump, model 1200 UV absorbance detector
set at 220 nm, Bioscan NaI scintillation detector). HPLC columns used
were a semipreparative column (Luna C18, 5 μm, 250 × 10
mm) and an analytical column (Luna, C18, 5 μ, 250 × 4.6
mm) from Phenomenex. Mass analyses were performed using an AB SCIEX
4000 QTRAP mass spectrometer with an electrospray ionization (ESI)
ion source. ⁶⁸Ga—gallium was eluted from an iThemba
Labs generator and purified according to previously published procedures
using a DGA resin column from Eichrom Technologies LLC.^{34 (link)} Radioactivity of ⁶⁸Ga-labeled peptides
was measured using a Capintec CRC-25R/W dose calibrator, and the radioactivity
in tissues collected from biodistribution studies were counted using
a PerkinElmer Wizard² 2480 gamma counter.

Lau J., Rousseau E., Zhang Z., Uribe C.F., Kuo H.T., Zeisler J., Zhang C., Kwon D., Lin K.S, & Bénard F. (2019). Positron Emission Tomography Imaging of the Gastrin-Releasing Peptide Receptor with a Novel Bombesin Analogue. ACS Omega, 4(1), 1470-1478.

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