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Cytorich blue preservative

Manufactured by BD
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CytoRich Blue Preservative is a liquid-based cytology preservative solution designed for the collection, transportation, and preservation of cellular samples. It is intended to maintain the integrity and morphology of cells prior to laboratory analysis.

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Lab products found in correlation

Automated stainer, by Agilent Technologies (1 mentions) Prepstain, by BD (1 mentions)

2 protocols using cytorich blue preservative

1

Thyroid Cytology Sample Preparation

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Thyroid samples were fixed in CytoRich Blue Preservative™ (BD). Unstained slides were then processed on the PrepStain™ (BD) instrument according to the manufacturer’s protocol. Immunocytochemistory (ICC) was performed on an automated stainer (DAKO) as described in the FFPE materials protocol.
Teshima M., Tokita K., Ryo E., Matsumoto F., Kondo M., Ikegami Y., Shinomiya H., Otsuki N., Hiraoka N., Nibu K.I., Yoshimoto S, & Mori T. (2019). Clinical impact of a cytological screening system using cyclin D1 immunostaining and genomic analysis for the diagnosis of thyroid nodules. BMC Cancer, 19, 245.
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2

Thyroid Cancer Specimen Analysis

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This analysis utilized 102 resected thyroid specimens between 2008 and 2017 at the National Cancer Center Hospital, Tokyo, Japan. We obtained tissue samples from thyroid surgery or head and neck surgery for malignant tumor. We prospectively collected 31 thyroid aspirates from the aforementioned 102 patients in liquid-based cytology (LBC; CytoRich Blue Preservative™from BD) from 2015 until 2017 which were formalin-fixed. Therefore, cases of cytology and cases of histology are the same. The 102 thyroidal tumor surgical specimens included 59 papillary carcinomas (PTC), 9 follicular carcinomas (FC), 7 poorly differentiated thyroid carcinomas (PDC), 1 medullary thyroid carcinoma (MTC), 5 anaplastic thyroid carcinomas (ATC), 2 well-differentiated tumors with uncertain malignant potential (WP), 7 follicular adenomas (FA), and Twelve individuals were background (BG) cases: 1 with adenomatous goiter (AG) and 11 with no neoplastic thyroid. BG consisted of normal thyroid tissue such as resections with surgery for hypopharyngeal carcinoma or laryngeal carcinoma.
Teshima M., Tokita K., Ryo E., Matsumoto F., Kondo M., Ikegami Y., Shinomiya H., Otsuki N., Hiraoka N., Nibu K.I., Yoshimoto S, & Mori T. (2019). Clinical impact of a cytological screening system using cyclin D1 immunostaining and genomic analysis for the diagnosis of thyroid nodules. BMC Cancer, 19, 245.
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