Avanto 1.5t

Manufactured by Siemens

Sourced in Germany, United States

The Avanto 1.5T is a magnetic resonance imaging (MRI) system manufactured by Siemens. It operates at a field strength of 1.5 Tesla, which is a common field strength for clinical MRI systems. The Avanto 1.5T is designed to acquire high-quality MRI images for diagnostic purposes.

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Avanto 1.5T scanner (52 citations) Magnetom Avanto 1.5T (29 citations) Avanto 1.5T MRI scanner (24 citations) Avanto 1.5T MR scanner (7 citations) Avanto 1.5T MRI (6 citations) Magnetom Avanto 1.5T MRI system (3 citations) Avanto 1.5T MR (2 citations) Avanto 1.5T MRI unit (2 citations) Avanto Tim 1.5T MRI scanner (2 citations)

64 protocols using avanto 1.5t

Multimodal Imaging for SEEG Trajectory Planning

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Patients undergoing planning for SEEG underwent volumetric Gd-enhanced T1-weighted MRI (Siemens Avanto 1.5-T, FOV 512 × 512 × 144, voxel size 0.5 × 0.5 × 1.5 mm³), and dedicated vascular imaging in the form of 3D phase-contrast MRI (Siemens Avanto 1.5-T, FOV 256 × 256 × 160, voxel size 0.85 × 0.85 × 1 mm³), and CT angiography (Siemens Somatom Definition AS, FOV 512 × 512 × 383, voxel size 0.43 × 0.43.0.75 mm³) in patients in whom high-risk perisylvian trajectories were anticipated.
Image integration and visualization was performed on EpiNav. The T1-weighted MR image was the reference image, upon which other modalities were coregistered. CT angiography and 3D phase-contrast images were processed using vessel extraction software available on EpiNav.¹² Gray matter, surface sulcal, and cortical segmentations were derived from T1-weighted MRI using Freesurfer software (version 5.0.0, Martinos Centre for Biomedical Imaging). Scalp exclusion masks were generated based on the T1-weighted MRI using basic imaging tools in EpiNav and MeshLab (version 1.3.3, University of Pisa). All models were stored and used as surface renderings (Fig. 1).

Nowell M., Sparks R., Zombori G., Miserocchi A., Rodionov R., Diehl B., Wehner T., Baio G., Trevisi G., Tisdall M., Ourselin S., McEvoy A.W, & Duncan J. (2015). Comparison of computer-assisted planning and manual planning for depth electrode implantations in epilepsy. Journal of neurosurgery, 124(6), 1820-1828.

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Lumbar MRI Examination Protocols

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Both pre-existing and prospective lumbar MRI examinations were performed using a Siemens (Iselin, NJ, USA) 1.5 T Avanto or 3 T Biograph MRI machine. Pre-existing spine MRI images were generated using a clinical unenhanced protocol; T2-weighted 5 mm axial and sagittal images were viewed on an Agfa (Mortsel, Belgium) PACS workstation using standard Agfa measuring tools and were amenable to 3D manipulation with the Agfa PACS tools. Prospective scans were performed using a single unenhanced 7 min MRI sequence [T2-weighted 3-dimensional (3D) turbo spin echo without fat suppression], which yielded a single 3D-dataset. From this dataset, 1.5 mm images in the axial, sagittal, and coronal planes were reconstructed at the scanner workstation and evaluated on the same Agfa PACS station.

Daniels M.L., Lowe J.R., Roy P., Patrone M.V., Conyers J.M., Fine J.P., Knowles M.R, & Birchard K.R. (2014). Standardization and validation of a novel and simple method to assess lumbar dural sac size. Clinical radiology, 70(2), 146-152.

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Resting-State fMRI of Incarcerated Individuals

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Resting-state fMRI images were collected on prison grounds using a mobile Siemens 1.5 T Avanto with advanced SQ gradients (max slew rate 200 T/m/s, 346 T/m/s vector summation, rise time 200 us) equipped with a 12-element head coil. The EPI gradient-echo pulse sequence (TR = 2000 ms, TE = 39 ms, flip angle 90°, FOV 24 × 24 cm, 64 × 64 matrix, 3.4 × 3.4 mm in-plane resolution, 4 mm slice thickness, 1 mm gap, 30 slices) effectively covered the entire brain (150 mm) in 2.0 s. Head motion was minimized using padding and restraint. The participants were asked to lay still, look at the fixation cross and keep eyes open during the five minute resting state fMRI scanning. Compliance with instructions was monitored by eye tracking.

Espinoza F.A., Anderson N.E., Vergara V.M., Harenski C.L., Decety J., Rachakonda S., Damaraju E., Koenigs M., Kosson D.S., Harenski K., Calhoun V.D, & Kiehl K.A. (2019). Resting-state fMRI dynamic functional network connectivity and associations with psychopathy traits. NeuroImage : Clinical, 24, 101970.

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Resting-state fMRI in Prison Population

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Resting state functional magnetic resonance images were collected on prison grounds using a mobile Siemens 1.5T Avanto with advanced SQ gradients (max slew rate 200T/m/s, 346T/m/s vector summation, rise time 200 us) equipped with a 12-element head coil. The EPI gradient-echo pulse sequence (TR 2000 ms,/TE = 39 ms, flip angle 90°, FOV 24 × 24 cm, 64 × 64 matrix, 3.4 × 3.4 mm in-plane resolution, 4 mm slice thickness, 1 mm gap, 30 slices) effectively covered the entire brain (150 mm) in 2.0 s. Head motion was minimized using padding and restraint. The participants were asked to lay still, look at the fixation cross and keep eyes open during the 5 min resting state fMRI scanning. Compliance with instructions was monitored by eye tracking.

Espinoza F.A., Vergara V.M., Reyes D., Anderson N.E., Harenski C.L., Decety J., Rachakonda S., Damaraju E., Rashid B., Miller R.L., Koenigs M., Kosson D.S., Harenski K., Kiehl K.A, & Calhoun V.D. (2018). Aberrant functional network connectivity in psychopathy from a large (N = 985) forensic sample. Human Brain Mapping, 39(6), 2624-2634.

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Standardized Multiparametric MRI Protocol

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MRI scans were performed on Siemens 1.5-T Avanto or 3.0-T Trio (Siemens Medical, Erlangen, Germany) scanners. The standard MRI protocol included axial T1-weighted images or inversion recovery-weighted images, T2-weighted images, and diffusion-weighted images. The custom diffusion sequence consisted of 2 × 2 × 2 mm voxels; 9300 ms repetition time; 96 ms echo time; 1710 Hz/Px; and 2 b-values, 0 and 1000. Two reviewers blinded to patient outcomes reviewed all MRIs and classified all images using the score described below. The interobserver variability was estimated, and in case of disagreement, consensus was obtained with a third blinded reviewer.

Esih K., Goričar K., Rener-Primec Z., Dolžan V, & Soltirovska-Šalamon A. (2021). CARD8 and IL1B Polymorphisms Influence MRI Brain Patterns in Newborns with Hypoxic-Ischemic Encephalopathy Treated with Hypothermia. Antioxidants, 10(1), 96.

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Lumbar MRI Examination Protocols

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Multimodal Brain Imaging Protocol

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Scanning centers either in Melbourne or Perth were used to acquire images using Siemens 3T Trio and Siemens 3T Skyra scanners (Melbourne) or Siemens 3T Verio and Siemens 1.5T Avanto scanners (Perth). The scans also included a 3D MPRAGE (Magnetization Prepared Rapid Acquisition Gradient Echo) image (voxel size 1.2 × 1 × 1 mm3, repetition time/echo time = 2300/2.98, flip angle = 9°). A 3D T2‐weighted Fluid‐attenuation inversion recovery (FLAIR) sequence, included in the image acquisition protocol, was obtained using two different sets of parameters. Gradient Recalled Echo (GRE) images used for SWI (Susceptibility‐Weighted Imaging) and QSM (Quantitative Susceptibility Mapping) were also acquired. Full details of protocols and parameters are described elsewhere (Fowler et al., 2021 ).

Pedrini S., Doecke J.D., Hone E., Wang P., Thota R., Bush A.I., Rowe C.C., Dore V., Villemagne V.L., Ames D., Rainey‐Smith S., Verdile G., Sohrabi H.R., Raida M.R., Taddei K., Gandy S., Masters C.L., Chatterjee P, & Martins R.N. (2022). Plasma high‐density lipoprotein cargo is altered in Alzheimer's disease and is associated with regional brain volume. Journal of Neurochemistry, 163(1), 53-67.

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Resting-state fMRI Acquisition in a Correctional Facility

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Resting-state functional magnetic resonance images were collected on the grounds of the correctional facility where participants were scanned using the Mind Research Network’s mobile Siemens 1.5 T Avanto with advanced SQ gradients (max slew rate 200 T/m/s, 346 T/m/s vector summation, rise time 200 us) equipped with a 12-element head coil. The EPI gradient echo pulse sequence (TR = 2000 ms, TE = 39 ms, flip angle = 75, FOV = 24 × 24 cm, 64 × 64 matrix, 3.75 × 3.75 mm in-plane resolution, 4 mm slice thickness, 1 mm gap, 27 slices) effectively covered the entire brain (150 mm) in 2.0 s. Head motion was minimized using padding and restraint. The participants were asked to lay still, look at the fixation cross and keep eyes open during the five-minute rsfMRI scanning. Compliance with instructions was monitored by eye-tracking.

Allen C.H., Shold J., Michael Maurer J., Reynolds B.L., Anderson N.E., Harenski C.L., Harenski K.A., Calhoun V.D, & Kiehl K.A. (2023). Aberrant resting-state functional connectivity associated with childhood trauma among juvenile offenders. NeuroImage : Clinical, 37, 103343.

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Structural MRI Analysis of Perisylvian Lesions

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Structural MRI scans were obtained for all participants who met safety
requirements for scanning (n=25) and were acquired at T₂,
T₃, and T₄ on the day of testing or within a week if
there were scheduling constraints (mean days between scans:
T₂-T₃=85, SD=4;
T₃-T₄=86 SD=6). T1-weighted images
were acquired on a Siemens 1.5T Avanto (n=7) or Siemens 3T Trio (n=18) scanner
with standard 20 channel head coils using standard acquisition sequences with a
voxel resolution of 1mm³ (see Supplementary Material).
Figure 3 displays the distribution
of lesions across 25 participants. All had extensive damage throughout the left
perisylvian middle cerebral artery territory. Three participants had additional
right hemisphere (non-aphasic) lesions (prior to their left hemisphere infarct)
and one of these participants also had a lesion in the left cerebellum.

Fleming V., Brownsett S., Krason A., Maegli M.A., Coley-Fisher H., Ong Y.H., Nardo D., Leach R., Howard D., Robson H., Warburton E., Ashburner J., Price C.J., Crinion J, & Leff A.P. (2020). Efficacy of spoken word comprehension therapy in patients with chronic aphasia: A cross-over randomised controlled trial with structural imaging. Journal of neurology, neurosurgery, and psychiatry, 92(4), 418-424.

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Standard Siemens 1.5T MRI Protocols

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MRI images were obtained using standard protocols on a Siemens 1.5T Avanto (Munich, Germany) scanner.

Mulcahy Levy J.M., Zahedi S., Griesinger A.M., Morin A., Davies K.D., Aisner D.L., Kleinschmidt-DeMasters B., Fitzwalter B.E., Goodall M.L., Thorburn J., Amani V., Donson A.M., Birks D.K., Mirsky D.M., Hankinson T.C., Handler M.H., Green A.L., Vibhakar R., Foreman N.K, & Thorburn A. (2017). Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors. eLife, 6, e19671.

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