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Incapacitance meter

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The Incapacitance meter is a device used to measure the electrical capacitance of a circuit or component. It provides a quantitative measurement of the ability of a circuit to store electrical charge.

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Lab products found in correlation

Opto varimex, by Columbus Instruments (2 mentions) Electronic von frey aesthesiometer, by IITC Life Science (2 mentions)

4 protocols using incapacitance meter

1

Detailed Preclinical Behavioral Assessments

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Mechanical sensitivity was assessed using an electronic von Frey aesthesiometer (IITC Inc., Woodland Hills, CA). Thermal sensitivity was assessed using a Hargreaves apparatus (Ugo Basile Plantar Test, Model 7371, Collegeville, PA). Hindpaw weight-bearing was measured using an incapacitance meter (Columbus Instruments, Columbus, OH). Horizontal locomotor activity was measured using a photobeam apparatus (Opto-varimex, Columbus Instruments, Columbus, OH): 15 photobeams cross the width of a 20 x 40 x 23-cm clear plastic rodent cage, with photobeams spaced 2.5 cm apart and 6.5 cm high. Paw edema was quantified by measuring maximal dorsal-ventral hindpaw thickness with calipers.
BRITCH S.C, & CRAFT R.M. (2021). No Antinociceptive Synergy between Morphine and delta-9-Tetrahydrocannabinol in Male and Female Rats with Persistent Inflammatory Pain. Behavioural pharmacology, 32(8), 630-639.
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2

Incapacitance Meter Assessment of Arthritic Pain

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To test the effect of IA ProGel-Dex treatment on amelioration of arthritic joint pain, the static weight distribution between the hind limbs of rats and mice was measured using an incapacitance meter (Columbus Instruments, Columbus, OH), which consists of two force transducers capable of measuring the body weight that the animal places on each hind limb. Animals were placed on the apparatus with their hind paws centered on the two force transducers, and the average body weight distribution in grams was recorded. The weight-bearing score was expressed as a ratio of the weight placed through the ipsilateral limb versus the sum of the weights placed through both the contralateral and ipsilateral limbs, with a ratio of 50% resulting from equal weight distribution across both hind limbs. Weight distribution was measured before model establishment, before drug administration, and daily after the initiation of the treatment.
Zhao G., Ren R., Wei X., Jia Z., Chen N., Sun Y., Zhao Z., Lele S.M., Zhong H.A., Goldring M.B., Goldring S.R, & Wang D. (2021). Thermoresponsive Polymeric Dexamethasone Prodrug for Arthritis Pain. Journal of controlled release : official journal of the Controlled Release Society, 339, 484-497.
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3

Knee Joint Pain Assessment in Rats

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A total of 31 male Wistar rats were randomly assigned into four groups: Group 1 - control naïve group (n = 6); Group 2- sham group (n = 7); Group 3- ACLT group (n = 10) and Group 4- osteochondral injury group (n = 8). The pain assessment was carried out weekly for up to eight weeks after operation using the hind limb weight-bearing test (Incapacitance meter; Columbus Instruments International, Columbus, Ohio). This technique measures the difference in weight bearing between the operated and non-operated contralateral limbs. Changes in the hind limb weight distribution (%HLWD) on the operated hind limb were used to determine the degree of knee joint pain. The %HLWD was determined as described previously.22 (link)
Tawonsawatruk T., Sriwatananukulkit O., Himakhun W, & Hemstapat W. (2018). Comparison of pain behaviour and osteoarthritis progression between anterior cruciate ligament transection and osteochondral injury in rat models. Bone & Joint Research, 7(3), 244-251.
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4

Multimodal Pain Assessment in Rodents

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Mechanical sensitivity was assessed using an electronic von Frey aesthesiometer (IITC Inc., Woodland Hills, CA). Thermal sensitivity was assessed using a Hargreaves apparatus (Ugo Basile Plantar Test, Model 7371, Collegeville, PA). Hindpaw weight-bearing was measured using an incapacitance meter (Columbus Instruments, Columbus, OH). Horizontal locomotor activity (a measure of pain suppressed behavior and drug-induced sedation) was measured using a photobeam apparatus (Opto-varimex, Columbus Instruments, Columbus, OH): 15 photobeams cross the width of a 20 × 40 × 23-cm clear plastic rodent cage, with photobeams spaced 2.5 cm apart and 6.5 cm high. Paw edema was quantified by measuring maximal dorsal-ventral hindpaw thickness with calipers. Open field measurements (to assess anxiety-like behavior) were taken in a 79-cm2 clear plexiglass box with 47-cm high walls and a dark floor that was marked into 16 equal squares (4 inner squares and 12 outer squares, each 19.75 cm2). Activity in the open field was recorded using a video camera mounted approximately 1.3 m above the open field floor.
Britch S.C, & Craft R.M. (2022). Cannabidiol and Delta-9-Tetrahydrocannabinol Interactions in Male and Female Rats with Persistent Inflammatory Pain. The journal of pain, 24(1), 98-111.
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