As a measure of motor ontogeny, mice from cohort 4 (n=5–7 per dose group) were repeatedly assessed on PND 18, 19, and 20, for exploratory activity in an open field chamber (42 cm × 42 cm; Columbus Instruments, Columbus, OH). Each chamber was outfitted with photocell detectors (0.32 cm diameter) spaced 2.5 cm from the chamber bottom and 1.27 cm apart linearly around the chamber. Ambulatory activity, as measured by photocell breaks, was recorded in 5-min epochs over a 20-min test session by Opto-Max version 2.27 software (Columbus Instruments).
Open field chamber
Manufactured by Columbus Instruments
The Open Field Chamber is a laboratory equipment designed to assess locomotor activity and exploratory behavior in small rodents. It consists of a square arena with high walls, allowing the animal to move freely and explore its surroundings. The chamber is equipped with a tracking system that records the animal's movements, providing data on parameters such as distance traveled, time spent in different zones, and rearing behavior.
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Lab products found in correlation
2 protocols using open field chamber
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Exploratory Motor Activity in Mice
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Exploratory Motor Activity in Mice
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On PND40, exploratory motor activity was measured in an open field chamber (42 × 42 cm; Columbus Instruments, Columbus, OH) outfitted with photocell detectors (0.32 cm diameter) spaced 5 cm from floor and 1.27 cm linearly apart around the chamber. Ambulatory activity was recorded in 5-min epochs over a 45-min test session. Total ambulatory activity, time spent in the margin (one-photocell width from the wall), and activity within the center area (20 × 20 cm) were recorded. Student’s t tests were used to analyze total ambulatory activity, total ambulatory time, total distance traveled, and ambulatory activity acclimation. Wilcoxon Rank Sum tests were used to analyze activity total margin time, margin distance, and center distance traveled. RM ANOVA was used to analyze ambulatory activity in 5-min epochs.
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