After dispensing the lens, the subjects were instructed to wear and care for them properly. Moreover, the subjects were advised to wear their OK lenses every night for 8–10 h. The examinations were performed before any lens wear (baseline) and 1 day, 1 week, 1 month, and 3 months, and then every 3 months until 1 year. Each follow-up included naked visual acuity, subjective and objective refraction (ARK-1, Nidek, Aichi, Japan), slit-lamp anterior segment examination (SL-D701, Topcon, Yamagata, Japan), and corneal topography. The AL was measured at 6- and 12-month follow-ups. Corneal topography data at 1-, 6-, and 12-month visits and AL at 6- and 12-month visits were used for statistical analysis.
Sl d701
Manufactured by Topcon
Sourced in Japan
The SL-D701 is a slit lamp biomicroscope designed for ophthalmic examinations. It provides a detailed view of the anterior segment of the eye, including the cornea, iris, and lens. The device features a high-quality optical system and illumination system to enable clear and precise observations.
Automatically generated - may contain errors
Lab products found in correlation
Ark 1, by Nidek (1 mentions)
Heidelberg spectralis hra oct, by Heidelberg Engineering (1 mentions)
Trc nw8, by Topcon (1 mentions)
Sl d7, by Topcon (1 mentions)
Mydrin p, by Santen (1 mentions)
Humphrey field analyzer, by Zeiss (1 mentions)
Trc 501x, by Topcon (1 mentions)
Iolmaster 700, by Zeiss (1 mentions)
California, by Optos (1 mentions)
8 protocols using sl d701
1
Longitudinal Evaluation of Orthokeratology Lenses
2
Evaluating Anterior Segment Imaging Variation
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It was a pilot study. A prospective non-randomized comparative analysis of inter-observer variation of SEC for anterior segment imaging was done. We enrolled Indian adult men and women who visited the cornea specialty outpatient clinic at Aravind Eye Hospital, Madurai, Tamil Nadu, India, from 01/10/2021 to 31/12/2021. Consecutive 100 patients with various corneal pathologies were examined on a conventional non portable slit lamp (Topcon SLD 701, Serial number Z162494) by a cornea consultant, and the diagnoses were recorded [Table 1 ]. On the same day, anterior segment videos of these 100 cases were documented using SEC by the same consultant (Fig. 2 ).
For the SEC examination, the SEC was placed 2–4 cm away from the cornea. This distance is important because the convex lens in front of the camera was designed to be in the best focus at 2–4 cm. Each video taken included at least three blinks in order to record a good image of the ocular surface. The resolution of the video was 4K, with a frame rate of 30 frames per second.
Finally, the recorded videos of the 100 cases were shown to two other cornea consultants (consultant 1/C1 and consultant 2/C2) separately on a computer, and they were asked to record their diagnosis based on videos only. Patient information and clinical details were individually masked to avoid any bias prior to analysis.
For the SEC examination, the SEC was placed 2–4 cm away from the cornea. This distance is important because the convex lens in front of the camera was designed to be in the best focus at 2–4 cm. Each video taken included at least three blinks in order to record a good image of the ocular surface. The resolution of the video was 4K, with a frame rate of 30 frames per second.
Finally, the recorded videos of the 100 cases were shown to two other cornea consultants (consultant 1/C1 and consultant 2/C2) separately on a computer, and they were asked to record their diagnosis based on videos only. Patient information and clinical details were individually masked to avoid any bias prior to analysis.
3
Corneal Staining using Fluorescein Strip
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A fluorescein strip (FLUO 900 Strip ®, Haag-Streit AG, Bern, Switzerland) was moistened with normal saline, shaken off and applied to the inferior fornix to stain the cornea. After 3–5 blinks, anterior segment images were obtained using the digital unit of a 5-megapixel camera (DC-4, Topcon, Tokyo, Japan) attached to a slit lamp biomicroscope (Topcon, SL-D701, Tokyo, Japan) under a cobalt filter. All image files were saved in JPEG format (2576 × 1934 pixels, 24-bit).
4
Primate Retinal Nerve Fiber Layer Imaging
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Pupils were dilated with 0.5% tropicamide. Lenses were examined and imaged with slit-lamp biomicroscopy (SL-D701; Topcon, Tokyo, Japan). Color fundus photographs were obtained with a conventional flash fundus camera (TRC-NW8, Topcon Corporation). Spectral domain OCT was performed with Heidelberg HRA-OCT (Spectralis; Heidelberg Engineering GmbH, Heidelberg, Germany) according to the standard manufacturer's protocol. For the measurement of peripapillary RNFL, a glaucoma protocol with a single circular B-scan of 12° diameter was performed. Each B-scan consisted of 512 A-scans along a 3.4-mm diameter circular ring around the optic disk. The RNFL was automatically segmented using the Heidelberg HRA-OCT software, and any inaccuracies were manually calibrated by a masked technician. The original reads of peripapillary retinal nerve fiber layer thickness (RNFLT) were measured from the Heidelberg HRA-OCT software. Of note, the ocular biometry studies in the current study includes all the macaques that were examined, including some macaques that presented macular drusenoid deposits (>63 µm) within 2 disc diameters of the fovea in color fundus photographs and OCT examinations, which were considered as pathogenic drusen according to Age-Related Macular Degeneration PPP 2019 by the American Academy of Ophthalmology.21 (link)
5
Corneal Photography Procedure and Dataset
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Corneal photography was performed by three certified ophthalmic technicians using Topcon SL-D7 slit-lamp microscopy (since June 2010), and Topcon SL-D701 (since January 2017). The resolution of captured photographs ranged from 1600 × 1200 to 2584 × 2000 pixels. The quality of image was assessed with following criterion – (1) image magnification was 10x or 16x and contained bulbar conjunctiva and full cornea; (2) image was correctly exposed and focused on cornea; (3) fluorescein-staining images were excluded. Any privacy information of patients was deleted. Slit-lamp images with multiple visits of the same patient were included. The labels of these slit-lamp photos were defined by their final etiological diagnosis.
6
Evaluating Postoperative Toric IOL Alignment
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Postoperatively, patients received examinations at 1 week, 1 month and 3 months. Postoperative 1- and 3-month follow-ups included slit-lamp examination, intraocular pressure, BCDVA, manifest refraction and digital anterior segment photography. Pupil was adequately dilated to visualize the toric axis marks and the edge of capsulorhexis with a mixture of phenylephrine and 0.5% tropicamide (Mydrin-P; Santen Pharmaceutical). The patients seated before slit-lamp microscope (TOPCON SL-D701, Japan) with an upright position, and digital anterior segment photographs (Topcon, Tokyo, Japan) were acquired and recorded. A conjunctive blood vessel or pigment was selected as a reference meridian to eliminate the influence of head tilt or eye rotation. The difference of IOL axial direction between intraoperative actual axis and postoperative alignment, the area of capsulorhexis and the overlapped area between capsulorhexis and IOL optic were calculated using the ruler tool of Rhinoceros 5.0 (Robert McNeel & Assoc, America) for three times. The mean value was selected for statistical analysis.
7
Standardized Fluorescein Imaging of Anterior Segment
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CFS was evaluated after instillation of 20 μL unpreserved 2% sodium fluorescein. Anterior segment slit-lamp photographs were acquired with the Topcon SL-D701 photography system (Topcon Medical Systems, Inc., Oakland, NJ) using the cobalt blue light and a 7503 Boston yellow filter. Photographs were acquired immediately after blinking, without using topical anesthesia. To standardize images, each photograph was obtained using the same magnification (×16), lighthouse angle (30°), and luminous intensity. Photographs were taken in both eyes; if both eyes were eligible, one image from one eye was selected based on satisfactory illumination, focus, and resolution.
8
Comprehensive Clinical Assessment of High Myopia
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Clinical assessment included comprehensive ophthalmological examination and electrophysiological testing. Patients’ own and family medical history was registered regarding other ophthalmological disorders than eoHM as well as any systemic diseases. Best corrected visual acuity (BCVA) was recorded (Snellen chart) and refractive error expressed as spherical equivalent (SE). High myopia was specified as SE > − 6.0 dioptres (D) on at least one of the eyes. Slit lamp biomicroscopy with applantion tonometry and fundus ophthalmoscopy in mydriasis was carried out (Topcon SL-D701, Topcon, Tokyo, Japan). Digital fundus photography (TRC-501X; Topcon, Tokyo, Japan) and in some cases also ultra-wide field (200°) fundus images (Optos® California, Optos, Marlborough, MA) were taken. Spectral domain optical coherence tomography (macular scan) (Heidelberg Engineering, Heidelberg, Germany) was performed where possible. Axial length measurements were executed with an optical biometry system (IOLMaster 700, Carl Zeiss, Jena, Germany). Automated kinetic full-field perimetry was carried out with Humphrey Field Analyzer (Carl Zeiss Meditec, Jena, Germany).
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