Dotarem gadoterate meglumine

Manufactured by Guerbet

Sourced in France

Dotarem/gadoterate meglumine is a gadolinium-based contrast agent used in magnetic resonance imaging (MRI) procedures. It is an intravenous injectable solution that enhances the visibility of internal body structures and organs during MRI scans.

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Lab products found in correlation

Ingenia, by Philips (1 mentions)

Spelling variants of this product

Dotarem (458 citations) Gadoterate meglumine (23 citations) Gadoterate/Dotarem (2 citations)

2 protocols using dotarem gadoterate meglumine

Comprehensive Cardiac MRI Protocol

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All subjects underwent CMR on the same 3 Tesla MRI scanner (Philips Ingenia; Philips Healthcare, Best, The Netherlands). ECG-gated balanced steady state free precession (bSSFP) two-dimensional cine sequences during breath hold were performed in standardized long axis and multiple short axis projections covering both ventricles from base to apex for anatomical and functional evaluation.
T1 mapping was performed in accordance with current recommendations^{6 (link)}, using 5(3)3 modified Look-Locker Inversion recovery (MOLLI) sequences for native and 4(1)3(1)2 MOLLI sequences for post-contrast images.
A gadolinium-based contrast agent (0.2 mmol/kg of Dotarem/gadoterate meglumine; Guerbet, Aulnay-sous-Bois, France) was injected to perform post-contrast T1 mapping and evaluate the presence of LGE in the steady state ≥ 10 min after contrast administration.

Andresen K., Klæboe L.G., Lie Ø.H., Broch K., Kvaslerud A.B., Bosse G., Hopp E., de Lange C., Haugaa K.H, & Edvardsen T. (2024). No adverse association between exercise exposure and diffuse myocardial fibrosis in male endurance athletes. Scientific Reports, 14, 6581.

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Phantom Imaging Study of SPCCT Contrast Agents

Cited 2 times

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For the purpose of evaluating in vitro, the capability of the SPCCT system to differentiate between the contrast agents, a phantom imaging study was performed. A custom-made polyoxymethylene cylindrical phantom with a diameter of 13 cm and 10 holes of 1.5 cm in diameter was used. Samples were loaded into the phantom using 1.5-mL polypropylene centrifuge tubes (Dominique Dutscher SAS, Brumath, France). A set of 10 tubes was prepared, consisting of contrast agents of a wide range of concentrations and diluted in phosphate buffered saline (PBS),^{9 (link),12 (link)} a tube of calcium phosphate (used as a bone simulant), and one of PBS. The contrast agents were gadolinium (Dotarem [gadoterate meglumine], 0.5 mmol/mL; Guerbet, Villepinte, France) and iodine (Xenetix [iobitridol], 350 mg/mL; Guerbet, Aulnay-sous-Bois, France) at concentrations of 2, 5, 8, and 12 mg/mL. The concentration ranges for the 2 clinically available contrast agents was based on current practice.

Si-Mohamed S., Thivolet A., Bonnot P.E., Bar-Ness D., Képénékian V., Cormode D.P., Douek P, & Rousset P. (2018). Improved Peritoneal Cavity and Abdominal Organ Imaging Using a Biphasic Contrast Agent Protocol and Spectral Photon Counting Computed Tomography K-Edge Imaging. Investigative Radiology, 53(10), 629-639.

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