Sodium bicarbonate (≥99.9%) was purchased from Ottogi Corp. (Anyang, Republic of Korea). Hydroxypropyl methylcellulose (Vivapharm Hypromellose 2910), triethyl citrate (≥99.0%), and magnesium stearate were obtained from Whawon Pharm. Co., Ltd. (Hwaseong, Republic of Korea), TCI Co., Ltd. (Tokyo, Japan), and Faci Asia Pacific Pte Ltd. (Singapore), respectively. Opadry (04K19229) and Acryl-Eze (93018509) were donated by Colorcon Inc. (Harleysville, PA, USA). All solutions were prepared with high-performance liquid chromatography (HPLC)-grade water purified with Arium Mini Plus (Sartorius, Goettingen, Germany) and cellulose nitrate membrane filters (47 mm, 0.2 μm, Whatman, Maidstone, UK). All other reagents were of analytical grade or better.
Acryl eze
Manufactured by Colorcon
Sourced in United States
Acryl-Eze is a laboratory equipment product designed for use in the pharmaceutical and related industries. It is a specialized instrument used for the application and evaluation of polymer-based functional coatings on solid dosage forms such as tablets and capsules. The core function of Acryl-Eze is to facilitate the controlled and consistent application of coating materials during the development and manufacturing processes.
Automatically generated - may contain errors
Lab products found in correlation
Cellulose nitrate membrane filter, by Cytiva (1 mentions)
Opadry, by Colorcon (1 mentions)
Arium mini plus, by Sartorius (1 mentions)
Colloidal silicon dioxide, by Evonik (1 mentions)
Microcrystalline cellulose, by JRS Pharma (1 mentions)
Fluid bed granulator, by Bosch (1 mentions)
Opadry clear, by Colorcon (1 mentions)
Poloxamer 188, by BASF (1 mentions)
4 protocols using acryl eze
1
Reagent Procurement for Pharmaceutical Research
2
Oral Delivery of ShK-235 in Enteric-Coated Capsules
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Torpac size 9 h gelatin capsules (Fairfield, NJ) were filled with either 0.3 mg synthetic ShK-235 or unflavored gelatin powder (Kraft Heinz) using the Torpac dosing kit. Each capsule was enteric-coated with Acryl-EZE® (Colorcon) prior to delivery via oral gavage to target content delivery to the small intestine.
3
Formulation and Production of Coated Tablets
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MSZ (Erregiere), microcrystalline cellulose (JRS Pharma), partially pregelatinized maize starch (Colorcon), povidone (BASF), magnesium stearate (Mosselman), lactose monohydrate (Meggle), croscarmellose sodium (FMC BioPolymer), colloidal silicon dioxide (Evonik), talc (Luzenac), calcium carbonate (Shangai Nuoceng Pharmaceuticals). All the components were of pharmaceutical grade and complied with the relevant monographs of the European Pharmacopoeia, 9th edition [10]. Coating system: Opadry clear (Colorcon), Triethylcitrate (Colorcon), Acryl-Eze (Colorcon). Also purified water (Ph. Eur., 2016) was used in the process.
Process steps and equipment -laboratory batches weighing -balance (Mettler Toledo), wet granulation -fluid bed granulator (Bosch), manual blending, tableting -eccentric press (Riva).
Process steps and equipment -pilot batches weighing -balances and scales (Mettler Toledo), wet granulation -fluid bed granulator (Bosch), blendingblender (Servolift), tableting -rotary tableting press (Fette 102i), oblong punch 18.2/7.7 mm, coatingcoating equipment (O'Hara Technologies).
Process steps and equipment -laboratory batches weighing -balance (Mettler Toledo), wet granulation -fluid bed granulator (Bosch), manual blending, tableting -eccentric press (Riva).
Process steps and equipment -pilot batches weighing -balances and scales (Mettler Toledo), wet granulation -fluid bed granulator (Bosch), blendingblender (Servolift), tableting -rotary tableting press (Fette 102i), oblong punch 18.2/7.7 mm, coatingcoating equipment (O'Hara Technologies).
4
Formulation and Characterization of IVM
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Pharmaceutical-grade IVM, Tween 80 (T80), Polyvinylpyrrolidone (PVP), Hydroxypropylmethylcellulose (HPMC) and Sodium Lauryl Sulfate (SLS) were purchased from Pura Química® (Córdoba, Argentina). Poloxamer 407 (P407) and Poloxamer 188 (P188) were purchased from BASF® (Rhein, Alemania) and was donated by Rumapel® (Buenos Aires, Argentina).. The water used in the study was ultrapure MilliQ water with a resistivity of 18.2 MΩ at 25 ° C and passed through a filter with a pore size of 0.22 µm. Acryl-EZE (Eudragit L100-55) was purchased from Colorcon®. All other reagents were of analytical grade if not specified otherwise.
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