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4 4 diphenylmethane diisocyanate

Manufactured by J&K Scientific
Sourced in China

4,4′-diphenylmethane diisocyanate is a chemical compound commonly used as a raw material in the production of polyurethane polymers. It is a colorless to light yellow liquid with a characteristic odor. The compound contains two isocyanate functional groups, which are reactive and can be used in various industrial applications.

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2 protocols using 4 4 diphenylmethane diisocyanate

1

Synthesis and Characterization of PEG-based Antimicrobial

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Epichlorohydrin (Dow Chemical, USA), trifluoride diethyl etherate (BF3–OEt2, Tianjin Lianxing Biotechnology Co. Ltd.), 3-bromo-1-propyne (Aladdin, Shanghai), sodium ascorbate (VcNa, Aladdin, Shanghai), trypticase soy agar medium (TSA, AOBOX, Hengshui), trypticase soy liquid medium (TSB, AOBOX, Hengshui), 1,4-butylene glycol (BDO, KESHI, Chengdu), 4,4′-diphenylmethane diisocyanate (MDI, J&K, Beijing), tetrahydrofuran (THF, Bioway, Shanghai), anhydrous magnesium sulfate (MgSO4, Tianjin ZhiYuan Reagent Co. Ltd.) N,N-diisopropylethylamine (DIEA, J&K, Beijing) can be used directly. All other chemical reagents such as sodium hydride (NaH), dimethyl sulfoxide (DMSO), sodium azide (NaN3), methanol, sodium hydroxide (NaOH), diethyl ether, cupric sulfate (CuSO4), phosphate buffer (PBS), polypropylene glycol (PPG), methylene chloride (DCM) and dimethylformamide (DMF) were purchased from Sinopharm. S. aureus and E. coli were purchased from Guangdong Institute of Microbiology. mPEG with number average molecular weights of 5000, 3350 and 1000 (mPEG-5000, mPEG-3350 and mPEG-1000, Aladdin) were used without further purification.
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2

Biocompatible Polyurethane Nanoparticles

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Polycaprolactone (PCL, Mw = 4000, CP) was purchased from Suyu plastic raw materials business department (Dongguan, China). 4,4′-diphenylmethane diisocyanate (MDI, 98%) was obtained from J&K Scientific Co., Ltd. (Beijing, China). Polyethylene glycol (PEG, Mw = 2000, CP), 1,4′-butanediol (BDO, AR), N,N-dimethylformamide (DMF, AR), soy lecithin (PC, BR), cholesterol (CH, ≥ 0.995), Tween 80 (T-80, CP), polyvinylpyrrolidone (PVP, ≥ 0.995) and anhydrous ethanol (GR) were bought from Sinopharm Chemical Reagent Co., Ltd. (Shanghai, China). Polyurethane (PU) was obtained from Shunte Plastic Co., Ltd. (Guangdong, China). Biaxially oriented polyethylene terephthalate (BOPET) was purchased from Yiwei Mechanical and Electrical hardware Co., Ltd. (Shanghai, China). Rosemary essential oil (REO, RG) was received from Chroma Dex Corporation (USA); 2,2-diphenyl-1-picrylhydrazyl (DPPH, ≥ 97.0%, HPLC) was acquired from Aladdin Biotechnology Co., Ltd. (Shanghai, China).
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