Ly30351

Manufactured by Merck Group

LY30351 is a laboratory equipment product developed by Merck Group. It is designed for general laboratory use and its core function is to perform specific tasks required in a research or analytical setting. No further details about its intended use or capabilities are provided.

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Lab products found in correlation

Mk 2206, by Cayman Chemical (2 mentions) Sb202190, by Merck Group (2 mentions) Recombinant human or mouse il 17a, by R&D Systems (2 mentions) D series resolvins, by Cayman Chemical (2 mentions) Rvd1 and rvd2, by Cayman Chemical (2 mentions) Sb216763, by Merck Group (2 mentions) Rabbit polyclonal antibody to del 1, by Proteintech (2 mentions) Rabbit anti phospho c ebpβ thr 188 and anti phospho threonine igg antibodies, by Cell Signaling Technology (2 mentions) Rabbit igg antibodies to gpr32, by Abcam (2 mentions) Fitc or pe conjugated goat anti rabbit igg, by Santa Cruz Biotechnology (2 mentions) Rabbit igg antibody to c ebpβ, by Santa Cruz Biotechnology (2 mentions) Ly294002, by Merck Group (2 mentions) Sp600125, by Merck Group (2 mentions)

2 protocols using ly30351

Resolvin-Mediated Inhibition of Inflammatory Signaling

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Recombinant human or mouse IL-17A was purchased from R&D Systems. The D series resolvins, RvD1 and RvD2, and MK2206 (Akt inhibitor) were from Cayman Chemical. SB202190 (p38 MAP kinase inhibitor), SB216763 (GSK-3β inhibitor), SN50 (NF-κB inhibitor), SP600125 (JNK inhibitor) were obtained from EMD-Millipore. LY294002 (PI3K inhibitor) and LY30351 (inactive analog of LY294002) were purchased from Sigma-Aldrich. Rabbit polyclonal antibody to Del-1 was from ProteinTech. Rabbit monoclonal antibody (mAb) to β-actin (13E5), rabbit IgG antibodies to total Akt (phosphorylation state–independent), phospho-Akt (Ser473), total GSK-3β and phospho-GSK-3β (Ser9), as well as rabbit anti-phospho-C/EBPβ (Thr-188) and anti-phospho-threonine IgG antibodies were purchased from Cell Signaling Technology. Rabbit IgG antibodies to GPR32 and to ALX/FPR2 were from Abcam and Abnova, respectively. FITC- or PE-conjugated goat anti-rabbit IgG and rabbit IgG antibody to C/EBPβ were purchased from Santa Cruz Biotechnology. All reagents (including those mentioned in the description of assays below) were used at doses based on our previously published work or on experiments in this study (see Supplementary fig. 1 and 4).

Maekawa T., Hosur K., Abe T., Kantarci A., Ziogas A., Wang B., Van Dyke T.E., Chavakis T, & Hajishengallis G. (2015). Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3β-C/EBPβ pathway. Nature Communications, 6, 8272.

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Resolution of Inflammation Pathways

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Recombinant human or mouse IL-17A was purchased from R&D Systems. The D series resolvins, RvD1 and RvD2, and MK2206 (Akt inhibitor) were from Cayman Chemical. SB202190 (p38 MAP kinase inhibitor), SB216763 (GSK-3β inhibitor), SN50 (NF-κB inhibitor), SP600125 (JNK inhibitor) were obtained from EMD-Millipore. LY294002 (PI3K inhibitor) and LY30351 (inactive analogue of LY294002) were purchased from Sigma-Aldrich. Rabbit polyclonal antibody to Del-1 was from ProteinTech. Rabbit monoclonal antibody (mAb) to β-actin (13E5), rabbit IgG antibodies to total Akt (phosphorylation state independent), phospho-Akt (Ser473), total GSK-3β and phospho-GSK-3β (Ser9), as well as rabbit anti-phospho-C/EBPβ (Thr-188) and anti-phospho-threonine IgG antibodies were purchased from Cell Signaling Technology. Rabbit IgG antibodies to GPR32 and to ALX/FPR2 were from Abcam and Abnova, respectively. FITC- or PE-conjugated goat anti-rabbit IgG and rabbit IgG antibody to C/EBPβ were purchased from Santa Cruz Biotechnology. All reagents (including those mentioned in the description of assays below) were used at doses based on our previously published work or on experiments in this study (see Supplementary Figs 1 and 4).

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