Cantaxanthin

Manufactured by Merck Group

Sourced in United States

Cantaxanthin is a type of carotenoid, a class of naturally occurring pigments found in various organisms. It is a synthetic analogue of astaxanthin, a naturally occurring carotenoid. Cantaxanthin is commonly used as a coloring agent in the pharmaceutical and food industries.

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2 protocols using cantaxanthin

Carotenoids and Fat-Soluble Vitamin Analysis

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Carotenoids and fat-soluble vitamin standards: E-β-apo-8′-carotenal, α-carotene, 13-Z-β-carotene, cryptoxanthin, lutein, zeaxanthin, astaxanthin, cantaxanthin, β-carotene, 9-Z-β-carotene, retinol, retinol acetate, 25-hydroxy cholecalciferol, cholecalciferol and α-tocotrienol were purchased from Sigma-Aldrich (St. Louis, MO, USA). The standard of 5-Z-lycopene was supplied by CaroteNature GmbH (Ostermundigen, Switzerland).
MeOH of LC-MS grade, n-hexane, ethanol and MTBE of HPLC grade, synthetic plasma and butylated hydroxytoluene (BHT) were obtained from Sigma-Aldrich. AMAC and AA of HPLC grade were purchased from Panreac Quimica SA (Barcelona, Spain). Ultrapure water (Milli-Q) was generated by a Millipore system (Millipore, Bedford, MA, USA).

Hrvolová B., Martínez-Huélamo M., Colmán-Martínez M., Hurtado-Barroso S., Lamuela-Raventós R.M, & Kalina J. (2016). Development of an Advanced HPLC–MS/MS Method for the Determination of Carotenoids and Fat-Soluble Vitamins in Human Plasma. International Journal of Molecular Sciences, 17(10), 1719.

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Isolation and Characterization of Carotenoids

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[A-2] (20 g) was dissolved in absolute ethanol (100 mL) with catalytic amount of NaOCH₃ and refluxed under nitrogen replacement for 30 min. (heated trans-esterification). After cooling to room temperature, the reaction mixture was neutralized by d-HCl. The crude product was concentrated in vacuo and separated by silica column chromatography (CHCl₃: acetone:methanol=5:1:0.1) to obtain capsanthin 1.3 g, capsorubin 200 mg and zeaxanthin 12 mg as chromatographically pure states. Those chemical identities were confirmed by PMR-spectral analysis (Rüttimann et al., 1983 (link); Sompong and Trakanrungroj, 2010 ). Other three xanthophylls (cantaxanthin, lutein and β-cryptoxanthin) and β-carotene were purchased from Sigma Aldrich Co (St. Louis, MO, USA).

Jo S.J., Kim J.W., Choi H.O., Kim J.H., Kim H.J., Woo S.H, & Han B.H. (2017). Capsanthin Inhibits both Adipogenesis in 3T3-L1 Preadipocytes and Weight Gain in High-Fat Diet-Induced Obese Mice. Biomolecules & Therapeutics, 25(3), 329-336.

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