Explore locus ct scanner

Manufactured by GE Healthcare

The EXplore Locus CT scanner is a laboratory-based computed tomography (CT) imaging system designed for small animal research. The EXplore Locus CT scanner captures high-resolution, three-dimensional images of small animal subjects, enabling researchers to study anatomical structures and physiological processes.

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GE eXplore Locus SP Micro-CT Scanner EXplore Locus SP Micro-CT scanner GE eXplore Locus micro-CT scanner EXplore Locus Scanner EXplore Locus CT scanners Scanners

2 protocols using explore locus ct scanner

Bone Microstructure Analysis in Mice

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Bone volume and architecture were evaluated by μCT. Mouse tibiae were fixed in neutral‐buffered formalin (10%) and scanned using the eXplore Locus CT scanner (General Electric) at 27‐μm resolution. Trabeculae were analyzed in 1 mm³ of proximal tibial epiphysis and 1.8 mm³ of cortical tibial diaphysis in four mice/group. Bone parameters were calculated with the MicroView 3D Image Viewer & Analysis Tool. The length of the tibia was measured from the intercondylar eminence to the medial malleolus.

Jimenez V., Jambrina C., Casana E., Sacristan V., Muñoz S., Darriba S., Rodó J., Mallol C., Garcia M., León X., Marcó S., Ribera A., Elias I., Casellas A., Grass I., Elias G., Ferré T., Motas S., Franckhauser S., Mulero F., Navarro M., Haurigot V., Ruberte J, & Bosch F. (2018). FGF21 gene therapy as treatment for obesity and insulin resistance. EMBO Molecular Medicine, 10(8), e8791.

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Micro-CT Analysis of Bone Composition

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Bone composition and architecture were evaluated by micro-computed tomography (μCT) analysis. Rat tibiae and femur were fixed in neutral‐buffered formalin (10%) and scanned using the eXplore Locus CT scanner (General Electric) at 27 µm resolution. Compact bone was analyzed in 6 cm³ of the cortical femoral and tibial diaphysis and trabecular bone in 2.5 cm³ of proximal femoral and tibial epiphysis. Bone parameters were calculated with the MicroView 3D Image Viewer & Analysis Tool 2.2. The length of the tibia was measured from the medial condyle to the medial malleolus.

Bertolin J., Sánchez V., Ribera A., Jaén M.L., Garcia M., Pujol A., Sánchez X., Muñoz S., Marcó S., Pérez J., Elias G., León X., Roca C., Jimenez V., Otaegui P., Mulero F., Navarro M., Ruberte J, & Bosch F. (2021). Treatment of skeletal and non-skeletal alterations of Mucopolysaccharidosis type IVA by AAV-mediated gene therapy. Nature Communications, 12, 5343.

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