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C57bl 6 ly5 1 cd45

Manufactured by Charles River Laboratories
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The C57BL/6-Ly5.1 (CD45.1) mouse strain is a widely used model in immunological research. The Ly5.1 allele, also known as CD45.1, is a genetic marker that allows the differentiation of cells derived from this strain from those of other strains. This model is commonly used in cell transfer experiments and other applications where the lineage of cells needs to be tracked.

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Lab products found in correlation

Sykfl fl, by Jackson ImmunoResearch (1 mentions) Pf4 icre, by Jackson ImmunoResearch (1 mentions) Rosa26idtr, by Jackson ImmunoResearch (1 mentions) C57bl 6j, by Jackson ImmunoResearch (1 mentions)

2 protocols using c57bl 6 ly5 1 cd45

1

Murine Hematopoietic Cell Lineage Tracing

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C57BL/6J (stock #00664), PF4-iCre (stock #008535), Sykfl/fl (stock # 017309) and ROSA26iDTR (stock #007900) were purchased from the Jackson Laboratory (JAX). C57BL/6-Ly5.1 (CD45.1, stock #564) was purchased from Charles River Laboratories. Mice were allowed to adjust to housing in the MSKCC vivarium for one week. Age-matched, sex-matched, and/or littermate controls were used for experiments as appropriate. Animals were euthanized by either pentobarbital injection or CO2 per IACUC guidelines.
Tischler B.Y., Tosini N.L., Cramer R.A, & Hohl T.M. (2020). Platelets are critical for survival and tissue integrity during murine pulmonary Aspergillus fumigatus infection. PLoS Pathogens, 16(5), e1008544.
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2

Conditional Gene Knockout Mice Generation

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Hoxaflox/flox [46 (link)], MxCre, C57Bl/6-Ly5.1/CD45.1, C57Bl/6J/CD45.2 (Charles River, Harlow, UK) and generated compound MxCre+/Hoxaflox/flox (MAFF) mice were maintained in SPF facilities under guidelines of The UK Animals (Scientific Procedures) Act 1986. Experimental procedures under PPL2760 were approved by the QUB Ethical Review Board and age-matched randomized animals were used throughout. Genotyping of litters was achieved by PCR (Figure S3, Table S3).
Kettyle L.M., Lebert-Ghali C.É., Grishagin I.V., Dickson G.J., O’Reilly P.G., Simpson D.A., Bijl J.J., Mills K.I., Sauvageau G, & Thompson A. (2019). Pathways, Processes, and Candidate Drugs Associated with a Hoxa Cluster-Dependency Model of Leukemia. Cancers, 11(12), 2036.
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