Mineral oil

Oranges (Citrus sinensis) and orange peel bagasse were purchased from a local supermarket in Campinas (Sao Paulo, Brazil). Hesperidin standard was bought from Sigma-Aldrich (St. Louis, MA, USA) at analytical grade (>97%). Calcium(II) chloride, copper(II) acetate, sodium hydroxide, and hydrochloric acid were from Labsynth (Diadema, Sao Paulo, Brazil) at practical grade. Deuterated solvent (DMSO-d₆) was purchased from Sigma-Aldrich (St. Louis, MA, USA). Methanol and phosphoric acid for the UHPLC assays were analytical grade (Avantor “Performance Materials”, Mexico^®, Ecatepec de Morelos, Mexico). ABIL^® Care 85 (Bis-PEG/PPg-16/16 PEG/PPG16/16 Dimethicone; Caprylic/Capric Triglyceride) were sampled from the EVONIK^® group (Essen, Germany). Muru muru (Astrocaryum murumuru Seed Butter), Cupuaçu butter (Theobroma grandiflorum Seed Butter), and Andiroba oil (Carapa Guianensis Seed Oil) were sampled from Amazon oil industry; Glyceryl monostearate, Mineral oil, Carbopol ULTREZ 10, Triethanolamine, and Vit E-acetate (α-Tocopheryl acetate) were bought from Fagron^® (Rotterdam, The Netherlands).

Native hyaluronic acid (sodium salt, molecular weight 1.2 MDa) and urea-crosslinked hyaluronic acid (molecular weight 2.0–4.0 MDa –raw material containing also pentylene glycol) were kindly given by I.R.A. Srl (Istituto Ricerche Applicate Srl, Usmate-Velate, Monza-Brianza, Italy). Sodium ascorbyl phosphate (known under the trade name STAY-C^®50) was purchased from DSM Nutritional Products Ltd. (Segrate, Milano, Italy). Phosphate buffered saline (PBS) and hexane were supplied by Sigma-Aldrich (Schnelldorf, Germany). Mineral oil was obtained from Fagron (Quarto Inferiore, Bologna, Italy). Sorbitan monooleate (Span 80) was provided by Acef (Fiorenzuola D’Arda, Piacenza, Italy).