Gsk429286a

Manufactured by Merck Group

Sourced in United States

GSK429286A is a laboratory equipment product. It is designed for use in scientific research and analysis. The core function of this product is to facilitate specific laboratory processes, but a detailed description cannot be provided while maintaining an unbiased and factual approach.

Automatically generated - may contain errors

Lab products found in correlation

2 protocols using gsk429286a

Quantitative Determination of Analytes

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KD025 (purity of = 99.42%) was purchased from MedChemExpress (Monmouth Junction, NJ, USA). GSK429286A (purity of > 98%) was supplied by Sigma-Aldrich (St Louis, MO, USA). HPLC-grade acetonitrile and formic acid were from Honeywell Burdick & Jackson (Muskegon, MI, USA) and Sigma-Aldrich (St Louis, MO, USA), respectively. All other analytical grade reagents were used without any further purification.

Yoon J.H., Nguyen T.T., Duong V.A., Chun K.H, & Maeng H.J. (2020). Determination of KD025 (SLx-2119), a Selective ROCK2 Inhibitor, in Rat Plasma by High-Performance Liquid Chromatography-Tandem Mass Spectrometry and Its Pharmacokinetic Application. Molecules, 25(6), 1369.

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Validated Compounds for Signaling Assays

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Defined compounds used for validation experiments were ordered de novo from various suppliers: SB-431542, PD-173074, U0126, Salinomycin, Nigericin, PD-161570, PD-166285, PD-166866, Idoxuridine and 5-Azacytidine (all from Sigma); Y-27632 2HCl, GSK429286A, Nintedanib, Pazopanib, Sorafenib, Vatalanib, Axitinib, Sunitinib, Erlotinib, Lapatinib, Gefitinib, Dasatinib, Crizotinib, Vandetanib, AEE788, Cediranib, AZD4547, CP673451, TSU-68 and KX2-391 (all from Selleck Chemicals); PP1, PP2, Rho kinase inhibitor V, SR-3677, GSK269962, SB-772077B (all from Tocris); Fasudil from Enamine; CAY10622 and PD-166326 from Cayman; BGJ398 from Axon Medchem; 5-Aza-2′-deoxycytidine from Chem-Impex. The reordered compounds were tested in extended dilution series ranging from 25 μM to 0.04 nM on TGFβ-treated NMuMG cells and from 25 μM to 1 nM on TGFβ-treated Py2T cells.

Lotz-Jenne C., Lüthi U., Ackerknecht S., Lehembre F., Fink T., Stritt M., Wirth M., Pavan S., Bill R., Regenass U., Christofori G, & Meyer-Schaller N. (2016). A high-content EMT screen identifies multiple receptor tyrosine kinase inhibitors with activity on TGFβ receptor. Oncotarget, 7(18), 25983-26002.

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