DSC (Q2000 TA instruments, United Kingdom) was performed to evaluate the percentage of drug crystallinity after tablet preparation. Tzero pans (TA instruments, Belgium) were filled with approximately 5–10 mg sample and placed in the DSC equipment after being non-hermetically sealed with Tzero lids using a Tzero Press (TA instruments, United Kingdom). An empty Tzero pan was used as a reference. A single heating run was performed at a heating rate of 10 °C/min from 0 to 150, 260 and 280 °C for MPT, MTF and THA formulations, respectively. The DSC apparatus was equipped with a refrigerated cooling system and dry nitrogen at a flow rate of 50 mL/min. The percentage of drug crystallinity was calculated by means of Equation (1) using the melt enthalpy obtained in DSC experiments.
Tzero press
Manufactured by TA Instruments
Sourced in United States
The Tzero Press is a laboratory instrument designed for sample compression and preparation. It provides precise control over the sample's physical state, enabling users to obtain consistent and reproducible results during thermal analysis. The core function of the Tzero Press is to prepare samples for further analysis using various thermal analysis techniques.
Automatically generated - may contain errors
Lab products found in correlation
Q2000, by TA Instruments (4 mentions)
Tzero pan, by TA Instruments (2 mentions)
Tzero hermetic lid, by TA Instruments (2 mentions)
Universal analysis 2000, by TA Instruments (1 mentions)
Tzero hermetic pan, by TA Instruments (1 mentions)
Q20 differential scanning calorimeter, by TA Instruments (1 mentions)
Cyclohexane, by Merck Group (1 mentions)
Discovery tga, by TA Instruments (1 mentions)
Dsc q2000, by TA Instruments (1 mentions)
6 protocols using tzero press
1
Quantifying Drug Crystallinity in Tablets
2
Thermal Analysis of Organic Polymers
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
A Tzero™ press (TA instruments, USA) was used to seal the pan containing OPX hermetically with its corresponding lid (TA instruments, USA) and an empty pan sealed with its lid was used as the reference. The samples were then heated from −20 to 140°C at 10°C min−1 under N2 gas (50 mL min−1) in a differential scanning calorimeter Q2000, (TA Instruments, USA). Data analysis was performed with TA Universal Analysis software.
3
Determining PCL Crystallinity by DSC
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
The produced filaments were analyzed by Differential Scanning Calorimetry (DSC; Q2000 TA instruments, Leatherhead, UK) to investigate the crystallinity of PCL. Tzero pans (TA instruments) were filled with approximately 5–10 mg of sample and placed in the DSC instrument after being non-hermetically sealed with Tzero lids using a Tzero Press (TA instruments). An empty Tzero pan was used as a reference. A heating run at a rate of 10 °C/min from 0 to 100 °C was performed. The DSC instrument was equipped with a refrigerated cooling system and dry nitrogen at a flow rate of 50 mL/min. The percentage of PCL crystallinity was calculated based on the following equation using the melt enthalpy obtained in the DSC experiments:
4
DSC Analysis of Enthalpic Relaxation
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
A 2 mm thick, ∅4 mm cylindrical sample was punched from a tensile specimen and placed in a pan (901683.901 Tzero Hermetic Pan, TA Instruments, USA), covered with a lid (Tzero Hermetic Lid 901683.901, TA Instruments, USA) crimped (Tzero Press, TA Instruments, USA), weighed (Quintex 124-1s, Sartorius, GER) and inserted into the DSC (Q2000, TA Instruments, USA). Temperature was swept twice from 20 °C to 300 °C and back to 20 °C at 20 °C min−1. DSC was applied to quantify enthalpic relaxation by integration of the endothermic peak at Tg.29 (link) Enthalpic relaxation (ΔH(Tg)) was determined in Universal Analysis 2000 (V. 4.5, TA Instruments, USA) by numerical integration with a linear extrapolation from the constant heat flow plateau after Tg subtracted the unaged ΔH(Tg) (t = 0 h) (Fig. 12 ). Onset Tg was determined during cooling, ΔCp was determined as the change in heat flow over Tg during heating and Tm was determined from integration with linear baseline from 240 to 280 °C.
5
Differential Scanning Calorimetry Analysis of Lipid Mixtures
6
Thermal Analysis of HEX D and HEX H
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
The melting points of HEX D and HEX H were examined using thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). TGA was performed using a Discovery TGA (TA Instruments, U.S.A.) system. Each active was weighed in an open aluminium pan (TA Instruments, U.S.A.) and then heated inside the Discovery TGA furnace. The starting temperature and the final temperature were set to 25°C and 400°C, respectively, while the heating ramp was 10°C/min. A nitrogen flow of 25 mL/min was supplied throughout the analysis in order to create an inert atmosphere around the sample. A DSC Q2000 (TA Instruments, U.S.A.) system was used for the DSC analysis. Each active was weighed in a hermetic aluminium pan (TA Instruments, U.S.A.) which was subsequently sealed with a hermetic aluminium lid (TA Instruments, U.S.A.) using a Tzero ™ press (TA Instruments, U.S.A.
). An empty hermetic aluminium pan (sealed with a hermetic aluminium lid) was used as a reference. Both the sample and reference were heated from 40°C to 290°C, with a heating ramp of10°C/min and a nitrogen flow of 50 mL/min.
). An empty hermetic aluminium pan (sealed with a hermetic aluminium lid) was used as a reference. Both the sample and reference were heated from 40°C to 290°C, with a heating ramp of10°C/min and a nitrogen flow of 50 mL/min.
About PubCompare
Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.
We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.
However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.
Ready to get started?
Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required
Revolutionizing how scientists
search and build protocols!