Modular p800 autoanalyzer

Manufactured by Roche

Sourced in Japan, Germany

The Modular P800 autoanalyzer is a compact and versatile laboratory instrument designed for automated clinical chemistry analysis. It is capable of performing a wide range of assays on a variety of sample types, including serum, plasma, and urine. The Modular P800 utilizes advanced photometric and electrochemical detection methods to deliver accurate and reliable results.

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Lab products found in correlation

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Spelling variants of this product

Modular P800 (128 citations) AutoAnalyzer (35 citations) Roche-Modular Autoanalyzer (10 citations)

9 protocols using modular p800 autoanalyzer

Biomarker Measurements in Cardiovascular Study

Cited 3 times

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hsCRP was measured in 2012–2013 in serum stored at −70°C since collection in visit 2 using the Roche Modular P800 autoanalyzer (Roche Diagnostics, Indianapolis, Indiana)^{7 (link)}. The coefficient of variation (CV) was 4.5%. hsCRP from visit 4 (1996–1998) stored plasma was measured using Siemens Dade Behring BN II^{26 (link)}. The reliability coefficient for the hsCRP assay was 0.99 based on 421-blinded replicates.
Fibrinogen was measured in 1987–1989 (visit 1) in stored plasma by the thrombin-time titration method with reagents obtained from General Diagnostics Organon Technica Company (West Chester, Pennsylvania)^{27 (link)}. The intraclass correlation coefficient (ICC) obtained from repeated testing on a sample of subjects over several weeks was 0.72.
GGT was measured in 2012–2013 in serum stored at −70°C since collection in visit 2 using the Roche Modular P800 autoanalyzer (Roche Diagnostics, Indianapolis, Indiana). The CV was 5.1% at 39 U/L and 2.9% at 171 U/L. GGT at visit 4 was measured in stored plasma using Olympus AU400^{28 (link)}. Intraassay coefficient of variation was 9.3% for GGT.
WBC count was measured in visit 2 using standard methods.

Al Rifai M., Schneider A.L., Alonso A., Maruthur N., Parrinello C.M., Astor B.C., Hoogeveen R.C., Soliman E., Chen L.Y., Ballantyne C.M., Halushka M.K, & Selvin E. (2014). sRAGE, Inflammation, and Risk of Atrial Fibrillation: Results from the Atherosclerosis Risk in Communities (ARIC) Study. Journal of diabetes and its complications, 29(2), 180-185.

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Serum Biomarker Analysis Protocol

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Blood samples were collected and centrifuged at 1500× g for 15 min at 4 °C to obtain serum samples, which were used to measure the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels by using a chemical analyzer (Modular P800 Autoanalyzer, Roche Diagnostics, Basel, Switzerland). Commercial kits were used to analyze the levels of endotoxin (A39553, Thermo, Rockford, IL, USA) and FFA (FA115, Randox, Crumlin, UK) per the manufacturers’ instructions.

Huang H.C., Lee P.N., Huang W.C, & Yang H.Y. (2023). Partial Replacement of Diet with Dehulled Adlay Ameliorates Hepatic Steatosis, Inflammation, Oxidative Stress, and Gut Dysbiosis in Rats with Nonalcoholic Fatty Liver Disease. Nutrients, 15(20), 4375.

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Comprehensive Blood Panel and Metabolic Markers

Cited 1 time

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Venous blood was taken the morning after polysomnographic evaluation. Blood routine, liver function, triglyceride (TG), total cholesterol (TC), and fasting glucose were tested in all patients. Blood routine was detected by Hitachi H-7600 autoanalyzer produced by Japan Co., Ltd., and blood biochemistry was performed using a Modular P800 autoanalyzer (Roche, Tokyo, Japan). PLR measured platelet count to lymphocyte count, and WBC/MPV measured white blood cell count to mean platelet volume. Platelet-related parameters including platelet count (PC), mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), average concentration of platelet contents (MPC) were also assessed. FLI and APRI were calculated using the following formulas [21 (link), 22 (link)]: FLI = (e^{0.953×ln(triglycerides)+0.139×BMI+0.718×ln(GGT)+0.053×waistcircumference−15.745})/(1 + e^{0.953×ln(triglycerides)+0.139×BMI+0.718×ln(GGT)+0.053×waistcircumference−15.745}) × 100 (with TG measured in mmol/l, GGT in U/l, and waist circumference in cm), APRI = (AST/upper limit of normal)/platelets (10⁹/L) × 100.

Chen M., Wang B., Huang J., Zhao J., Chen J, & Chen G. (2022). The role of platelet-related parameters for the prediction of NAFLD in OSAHS patients. BMC Pulmonary Medicine, 22, 487.

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Monitoring Iron Metabolism after IV Administration

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At 24 hours after the first, second, and fifth IV iron administration (ie, on days 1, 8, and 29), blood samples were collected from the tail vein in capillary tubes following 14 hours’ fasting. Hb levels were determined with a Sysmex XT-1800i (Hoffman-La Roche, Basel, Switzerland). Levels of serum iron and liver enzymes (AST, ALT, and ALP) were measured by colorimetric and ultraviolet methods, respectively, using a Modular P800 autoanalyzer (Hoffman-La Roche) with the corresponding reagents (Hoffman-La Roche). Aliquots of sera and urine were assayed for creatinine with the enzymatic ultraviolet method (Randox Laboratories, Crumlin, UK). Creatinine clearance was calculated as urine volume × urine creatinine/serum creatinine. Proteinuria was determined by the sulfosalicylic acid method. Transferrin saturation (TSAT) was calculated as serum iron concentration (μg/L)/total iron-binding capacity (μg/L) ×100.27 (link),28 (link)

Toblli J.E., Cao G., Rico L, & Angerosa M. (2017). Cardiovascular, liver, and renal toxicity associated with an intravenous ferric carboxymaltose similar versus the originator compound. Drug Design, Development and Therapy, 11, 3401-3412.

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Serum Calcium and Albumin Analysis

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The serum samples were then analyzed for calcium by Ortho–Cresolphthalein Complexone (oCPC) method and albumin by bromocresol green (BCG) dye binding method on modular P-800 autoanalyzer (Roche Diagnostics, Germany) and then the same samples were analyzed for ionized calcium by potentiometry on combiline direct ISE analyzer (Eschweiler products, Germany). Routine quality control check was done by quality control samples provided by Roche on autoanalyzer and those provided by Eschweiler products on direct ISE analyzer. The samples were analyzed only after internal quality check were found to be satisfactory pertaining to patient samples.
The units of TCa assayed on autoanalyzer were then converted from mg/dL to mmol/L using conversion factor of 0.25 and albumin was converted from g/dL to g/L using conversion factor of ten so as to facilitate their use in formulae. The free ionized calcium as measured on direct ISE analyzer was already in units of mmol/L.

Mir A.A., Goyal B., Datta S.K., Ikkurthi S, & Pal A. (2016). Comparison Between Measured and Calculated Free Calcium Values at Different Serum Albumin Concentrations. Journal of Laboratory Physicians, 8(2), 71-76.

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Anthropometric and Metabolic Assessments

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Body weight and height were measured in bare feet and light clothing in the morning with the same equipments. Body mass index (BMI) was calculated by dividing body weight to height square (kg/m²). Waist circumference was measured at a level midway between the lower costal margin and the iliac crest. Blood pressure was gauged by a standard mercury sphygmomanometer on the right arm with the participants in a sitting position after 5 min of rest—the average of two measurements, with 1-min interval, was considered. Fasting blood was taken in the morning for the measurement of serum glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (Alk Phos), total bilirubin (T. bilirubin), gamma glutamyltransferase (GGT), and lipid profile comprising total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), and triglycerides (TG). All blood samples were analyzed using the Modular P800 autoanalyzer (Roche, Tokyo, Japan). High-sensitivity C-reactive protein (hs-CRP) was measured with a BNII nephelometer (Dade Behring, Deerfield, IL, USA). The value of mean arterial pressure (MAP) was calculated by the following equation: diastolic blood pressure + 1/3 (systolic blood pressure − diastolic blood pressure).

Lin Q.C., Chen L.D., Chen G.P., Zhao J.M., Chen X., Huang J.F, & Wu L.H. (2014). Association between nocturnal hypoxia and liver injury in the setting of nonalcoholic fatty liver disease. Sleep & Breathing = Schlaf & Atmung, 19(1), 273-280.

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Anthropometric and Biochemical Assessment

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Body mass index (BMI) was calculated as: weight (kg; without heavy clothing) divided by the square of height (m). Waist circumference (WC; measured midway between the lower rib margin and the iliac crest) and neck circumference (NC; measured at mid-neck height between the mid-cervical spine to mid-anterior neck) were measured to within 1 mm. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured by an automated sphygmomanometer on the right arm in the sitting position after 5 minutes of rest. Blood samples were taken in the morning after a 12-hour fast and were analyzed to measure blood glucose, liver function (including alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin (T. bilirubin) and gamma glutamyl transferase (GGT)), and lipid profile (including levels of triglycerides (TG), total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), and low-density lipoprotein- cholesterol (LDL-C)). All biochemical parameters were measured using the Modular P800 autoanalyzer (Roche, Tokyo, Japan). High-sensitivity C-reactive protein (hs-CRP) was analyzed using a BNII nephelometer (Dade Behring, Deerfield, IL, USA).

Huang J., Chen L., Li X., Chen M., Lin T, & Chen G. (2023). Association Between Metabolic-Associated Fatty Liver Disease and Obstructive Sleep Apnea: A Cross-Sectional Study. Nature and Science of Sleep, 15, 49-57.

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Clinical and Biochemical Measurements

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Details on clinical and biochemical measurements of all subjects were collected: history of medication (including lipid-lowering drugs, hypoglycemic drugs, and antihypertensive agents), smoking habits, and alcohol consumption. Each subject underwent measurements of weight, height, and waist circumference after the removal of shoes and a heavy coat. Body mass index (BMI) was calculated as weight in kilograms divided by the square of height in meters, and waist circumference was determined at the midpoint between the inferior costal margin and the iliac crest.
Venous blood was drawn in the morning after an overnight fast. The lipid and lipoprotein profile included total cholesterol (TC), triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C), and low-density lipoprotein-cholesterol (LDL-C). The liver enzymes ALT and AST were assayed. All biochemical blood measurements were analyzed using standard laboratory procedures on the Modular P800 autoanalyzer (Roche, Tokyo, Japan).

Jin Y.X., Wang B.Y., Wang X.L., Yu X., Chen L.D., Yang Y.S, & Huang J.F. (2023). Relationship between Obstructive Sleep Apnea and Liver Abnormalities in Older Patients: A Cross-Sectional Study. International Journal of Clinical Practice, 2023, 9310588.

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Plasma and Serum Biochemical Analysis

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Concentrations of ALT (U/L), AST (U/L), IP (mg/dL), K⁺ (mmol/L), and LDH (U/L) in the plasma and serum samples were determined using an automated chemistry analyzer (Roche Modular P800 autoanalyzer; Roche Diagnostics GmbH, Mannheim, Germany) with the appropriate reagents (Roche Diagnostics) according to the recommended protocol. Free-hemoglobin concentrations (mg/dL) in the plasma and serum samples were measured using the QuantiChrom Hemoglobin Assay Kit (Bioassay Systems, Haywood, CA, USA) according to the manufacturer's recommendations. All samples were measured in duplicate.

Lee J.E., Hong M., Park S.K., Yu J.I., Wang J.S., Shin H., Kim J.W., Han B.G, & Shin S.Y. (2015). Inorganic Phosphorus and Potassium Are Putative Indicators of Delayed Separation of Whole Blood. Osong Public Health and Research Perspectives, 7(2), 90-95.

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