Hy 101120

Manufactured by MedChemExpress

HY-101120 is a laboratory instrument used for the purification and analysis of chemical compounds. It employs a specific technique to separate and identify the components of a mixture. The core function of this product is to facilitate the process of isolating and characterizing substances in a research or analytical setting.

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Lab products found in correlation

N acetyl l cysteine nac, by Beyotime (1 mentions) Go6983, by Selleck Chemicals (1 mentions) Isobutylmethylxanthine, by Merck Group (1 mentions) Human insulin, by Merck Group (1 mentions) Dexamethasone (dex), by Merck Group (1 mentions) Indomethacin, by Merck Group (1 mentions) Sb203580, by Bio-Techne (1 mentions)

3 protocols using hy 101120

Investigating CREB inhibitor effects

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DTX stock solution was purchased from Hengrui (H20020543, Jiangsu, China) and diluted to indicated concentrations immediately before treatment. The commercial Creb inhibitor 666–15 (HY-101120, MedChemExpress) was used at 200 ng/mL in vitro and 10 mg/kg in vivo. The rmCcl3 (450-MA-050/CF, R&D) was used at 5 µg/mice in vivo. N-acetyl-L-cysteine (NAC) (S0077, Beyotime) was used at 10 mM for indicated time. Hydrogen dioxide (H₂O₂) (CN51001, Chinasun Specialty Products Co, Ltd) was administered at indicated concentrations.

Sheng D., Ma W., Zhang R., Zhou L., Deng Q., Tu J., Chen W., Zhang F., Gao N., Dong M., Wang D., Li F., Liu Y., He X., Duan S., Zhang L., Liu T, & Liu S. (2022). Ccl3 enhances docetaxel chemosensitivity in breast cancer by triggering proinflammatory macrophage polarization. Journal for Immunotherapy of Cancer, 10(5), e003793.

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Selective CREB and Pan-PKC Inhibition in MDA-MB-231 Cells

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A selective CREB inhibitor, 666-15 (HY-101120, MedChemExpress), was purchased and used in our experimental design to treat MDA-MB-231 cells at a concentration of 73 nM. A pan-PKC inhibitor (Go 6983, Selleck) was purchased and used to treat MDA-MB-231 cells at a concentration of 5 μM.

Qin Y., Chen W., Jiang G., Zhou L., Yang X., Li H., He X., Wang H.L., Zhou Y.B., Huang S, & Liu S. (2020). Interfering MSN-NONO complex–activated CREB signaling serves as a therapeutic strategy for triple-negative breast cancer. Science Advances, 6(8), eaaw9960.

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Adipocyte Differentiation Assay

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Human insulin, isobutylmethylxanthine (IBMX), dexamethasone, T3, and indomethacin were purchased from Sigma-Aldrich. H89 and SB203580 were purchased from Tocris Bioscience. HY101120 was obtained from MedChem Express.

Wang X., Li Y., Qiang G., Wang K., Dai J., McCann M., Munoz M.D., Gil V., Yu Y., Li S., Yang Z., Xu S., Cordoba-Chacon J., De Jesus D.F., Sun B., Chen K., Wang Y., Liu X., Miao Q., Zhou L., Hu R., Ding Q., Kulkarni R.N., Gao D., Blüher M, & Liew C.W. (2022). Secreted EMC10 is upregulated in human obesity and its neutralizing antibody prevents diet-induced obesity in mice. Nature Communications, 13, 7323.

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