Ccl5 mice

Manufactured by Jackson ImmunoResearch

Sourced in United States

Ccl5−/− mice are genetically modified mice that lack the Ccl5 gene, also known as the Rantes gene. These mice are often used as a model to study the role of the Ccl5 chemokine in various biological processes.

Automatically generated - may contain errors

Lab products found in correlation

C57bl 6 mice, by Taconic Biosciences (1 mentions) Wt c57bl 6 mice, by Jackson ImmunoResearch (1 mentions) Wt balb c, by Jackson ImmunoResearch (1 mentions) C57bl 6ntac mice, by Taconic Biosciences (1 mentions) Ccr5 mice, by Taconic Biosciences (1 mentions) B6.129p2 ccl5tm1hso j, by Jackson ImmunoResearch (1 mentions)

4 protocols using ccl5 mice

Genetically Modified Mouse Models

Check if the same lab product or an alternative is used in the 5 most similar protocols

One-month-old male wild-type (B6-M) and athymic (Foxn1^−/−; B6NU-M) C57BL/6 mice were purchased from Taconic Biosciences. Cx3cr1^+/GFP and Ccr2^+/RFP mice (Keiko Hirose, Washington University) were intercrossed to generate Cx3cr1^−/−Ccr2^−/− and Ccr2^−/− mice. Ccl5^−/− mice were purchased from the Jackson Laboratory (005090). Nf1^flox/flox and Nf1^flox/mut; GFAP-Cre mice were generated as described previously (Bajenaru et al. 2003 (link)). All mice were maintained on a C57BL/6 background and used in accordance with an approved Animal Studies Committee protocol.

Pan Y., Xiong M., Chen R., Ma Y., Corman C., Maricos M., Kindler U., Semtner M., Chen Y.H., Dahiya S, & Gutmann D.H. (2018). Athymic mice reveal a requirement for T-cell–microglia interactions in establishing a microenvironment supportive of Nf1 low-grade glioma growth. Genes & Development, 32(7-8), 491-496.

+ Open protocol

+ Expand

Genetically Engineered Mice for Research

Check if the same lab product or an alternative is used in the 5 most similar protocols

WT BALB/c, WT C57BL/6 mice and ccl5^−/− mice on C57BL/6 background were purchased from the Jackson Laboratories (ME, USA). ccl5^−/− mice on BALB/c background were generated as previously described (11 (link)). All mice were maintained in a pathogen-free facility. All animal protocols are proved by the Research Animal Resource Center at Weill Cornell Medicine.

Ban Y., Mai J., Li X., Mitchell-Flack M., Zhang T., Zhang L., Chouchane L., Ferrari M., Shen H, & Ma X. (2017). Targeting autocrine CCL5-CCR5 axis reprograms immunosuppressive myeloid cells and reinvigorates antitumor immunity. Cancer research, 77(11), 2857-2868.

+ Open protocol

+ Expand

Genetic Mouse Models of Neurofibromatosis Type 1

Check if the same lab product or an alternative is used in the 5 most similar protocols

All mice, including Nf1^+/− mice (neomycin sequence insertion within exon 31 of the murine Nf1 gene), Nf1^flox/mut; GFAP-Cre (OPG) mice (Nf1^+/− mice with somatic Nf1 gene inactivation in neuroglial progenitors at E15.5) and Nf1^flox/flox mice (controls)^{66 (link),67 (link)}, were maintained on a strict C57BL/6 background and used in accordance with an approved Animal Studies Committee protocol at Washington University. Ccl5^−/− mice were purchased from the Jackson Laboratory (JAX; 005090). Mice were housed in barrier facilities with controlled light–dark cycles (12:12 h) and ad libitum access to food and water.

Guo X., Pan Y., Xiong M., Sanapala S., Anastasaki C., Cobb O., Dahiya S, & Gutmann D.H. (2020). Midkine activation of CD8+ T cells establishes a neuron–immune–cancer axis responsible for low-grade glioma growth. Nature Communications, 11, 2177.

+ Open protocol

+ Expand

CCR5 Knockout Mouse Protocol

Check if the same lab product or an alternative is used in the 5 most similar protocols

Ccr5 knockout (Ccr5^−/−) mice were purchased from Taconic Farms (Germantown, NY; B6.129P2-Ccr5tm1Kuz N10). Experimental WT, Ccr5^+/− and Ccr5^−/− mice (3 to 5 months old) were generated by intercrossing Ccr5^+/− mice. Littermates were used for Ccr5 KO linking test. cFos-tTa mice that express tetracycline transactivator (tTA) protein under the control of the c-Fos (also known as Fos) promoter were maintained in a C57BL/6N background. Ccrl5 knockout (Ccl5^−/−) mice were purchased from Jackson lab (B6.129P2-Ccl5tm1Hso/J). 16-month-old male C57BL/6Nia were purchased from NIA for Ccr5 expression detection and linking test. 11-week-old male C57BL/6N Tac mice were purchased from Taconic Farms (Germantown, NY) for all other experiments. Mice are housed in an AAALAC accredited facility with 12-12 light/dark cycles. Housing conforms to The Guide for the Care and Use of Laboratory Animals, 8th edition. The temperature setpoint is 72 degrees plus or minus 3 degrees; the humidity range is between 30% to 70%. All experiments were performed during the light phase of the cycle. All studies were approved by the Animal Research Committee at UCLA.

Shen Y., Zhou M., Cai D., Filho D.A., Fernandes G., Cai Y., de Sousa A.F., Tian M., Kim N., Lee J., Necula D., Zhou C., Li S., Salinas S., Liu A., Kang X., Kamata M., Lavi A., Huang S., Silva T., Do Heo W, & Silva A.J. (2022). CCR5 closes the temporal window for memory linking. Nature, 606(7912), 146-152.

+ Open protocol

+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!