All patients underwent preoperative examinations (Philips 3.0 T Ingenia, Philips Medical System, The Netherlands). Routine T1-weighted imaging (T1WI), T2-weighted imaging (T2WI) and DWI were acquired using an 8-channel phased-array carotid coil. T1/T2-weighted turbo spin-echo sequences were used to visualize the morphologic features of thyroid nodules (FOV, 22 × 22 cm; voxel size, 0.85 × 0.85 mm/0.76 × 0.76 mm; number of slices, 20; slice thickness, 4 mm; slice spacing, 0.6 mm; repetition time (TR) and echo time (TE) of 525/36 ms and 3600/100 ms; turbo factor, 8 and 22; flip angle, 90°; and total acquisition time, 6:34 min) and to gain sufficient anatomical information. An rFOV DWI examination using a two-dimensional (2D) spatially selective echo-planar radiofrequency (RF) excitation technique was performed with the following parameters: TR/TE, 1351/69 ms; turbo factor, 29; EPI factor, 29; FOV, 160 × 47 mm; voxel size, 1.50 × 1.50 mm; NSA 4; 10 to 15 slices with thicknesses of 5.0 mm and a 1.0-mm gap. Eight b values (0, 20, 50, 100, 200, 400, 600, and 990 s/mm2) were used, and the acquisition time was 5:37 min.
Ingenia 3.0t
Manufactured by Philips
Sourced in Netherlands, Germany, United States
The Ingenia 3.0T is a magnetic resonance imaging (MRI) system manufactured by Philips. It operates at a magnetic field strength of 3.0 Tesla, which provides high-resolution imaging capabilities. The Ingenia 3.0T is designed to perform MRI scans and produce detailed images of the body's internal structures.
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Lab products found in correlation
Achieva 3.0t, by Philips (5 mentions)
Osirix md software, by Pixmeo (4 mentions)
Discovery mr750 3.0t, by GE Healthcare (3 mentions)
Magnetom avanto fit, by Siemens (3 mentions)
Ecat high resolution research tomograph hrrt, by Siemens (2 mentions)
Magnevist, by Bayer (2 mentions)
Verio 3.0t, by Siemens (2 mentions)
Gadopentetate dimeglumine, by Bayer (2 mentions)
Somatom force, by Siemens (2 mentions)
Somatom definition as, by Siemens (2 mentions)
Ge signa excite hdxt, by GE Healthcare (1 mentions)
Crl nih foxn1rnu, by Charles River Laboratories (1 mentions)
Omniscan, by GE Healthcare (1 mentions)
Achieva 3.0t tx, by Philips (1 mentions)
Magnetom aera, by Siemens (1 mentions)
Prussian blue, by Merck Group (1 mentions)
Dneasy blood and tissue kit, by Qiagen (1 mentions)
Signa hdxt 1.5t, by GE Healthcare (1 mentions)
Magnetom aera 1.5t, by Siemens (1 mentions)
Magnetom skyra 3.0t, by Siemens (1 mentions)
133 protocols using ingenia 3.0t
1
Comprehensive Thyroid Nodule Imaging Protocol
2
Multimodal Brain Imaging Protocol
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Standardized T1, T2, fluid attenuated inversion recovery, and diffusion-weighted images (DWIs) were acquired for all participants at the Chuncheon Sacred Heart hospital using the same 3.0 T magnetic resonance imaging (MRI) scanner (Philips 3.0T Ingenia, Koninklijke Philips Electronics N.V., Amsterdam, Netherland). Images were obtained in one session for all participants, and all MR images were obtained in the same orientation and slice positions. DWIs were obtained using the following parameters: axial slice thickness of 3.0 mm, inter-slice thickness of 4.5 mm, repetition time of 3980 ms, echo time of 84 ms, flip angle of 90°, and matrix size of 256 × 256 pixels.
3
Multimodal Neuroimaging of Alzheimer's Biomarkers
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All subjects underwent a structural brain MRI including T1-weighted and T2-FLAIR sequences. Structural brain images were acquired by two different scanners, either with Philips Ingenuity 3.0 T TF PET/MRI (n = 38; Philips Healthcare, Amsterdam, the Netherlands) or Philips Ingenia 3.0 T (n = 22; Philips Healthcare, Amsterdam, the Netherlands).
MRI was used to acquire volumetric variables (hippocampal volume, parahippocampal volume and entorhinal volume), global cortical atrophy score, medial temporal lobe atrophy score, and total volume of white matter hyperintensities. To determine brain Aβ load, [11C]PiB PET scans (n = 60) were acquired from 40 to 90 min post injection (mean injected dose 497 [30 ] MBq) with an ECAT high-resolution research tomograph (HRRT, Siemens Medical Solutions, Knoxville, TN).
MRI was used to acquire volumetric variables (hippocampal volume, parahippocampal volume and entorhinal volume), global cortical atrophy score, medial temporal lobe atrophy score, and total volume of white matter hyperintensities. To determine brain Aβ load, [11C]PiB PET scans (n = 60) were acquired from 40 to 90 min post injection (mean injected dose 497 [30 ] MBq) with an ECAT high-resolution research tomograph (HRRT, Siemens Medical Solutions, Knoxville, TN).
4
Multimodal Liver Imaging Protocol
5
Hepatocellular Carcinoma Induction in Rats
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Animal experiments were approved by the local governmental committee for animal protection and welfare (Tierschutzbehörde Regierung von Oberbayern, Protocol Nr. 55.2-1-54-2532-25-2016). All procedures were carried out in accordance with applicable laws and regulations. Two animal cohorts were employed in the study. Cohort A included 17 male Wistar rats (RccHan:WIST; six to eight weeks old; Envigo; Re Schaijk, Netherlands), consisting of 13 rats in which HCCs were induced by oral administration of 0.01% diethyl-nitrosamine (DENA, SigmaAldrich) dissolved in drinking water over ten weeks, as previously described19 (link), and 4 healthy control rats. Cohort B consisted of ten male nude rats (Crl:NIH-Foxn1rnu; six to eight weeks old; Charles River, Sulzfeld, Germany) in which subcutaneous tumors were implanted in each flank. Tumor screening in cohort A rats was performed by T2-weighted (T2w) anatomical imaging on a human 3 T clinical MRI system (Philips Ingenia 3.0 T; Philips Medical, Amsterdam, Netherlands) as previously described12 (link). Tumor screening in cohort B rats was performed by caliper measurement. Tumor bearing animals were included in HPMRS(I) experiments once tumors reached ≥ 10 mm in diameter.
6
Macaque Brain Imaging and Optical Probing
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One healthy adult Japanese macaque monkey (female; 5.0 kg) without any history of experimentation was used. The positions of M1 and the premotor area (PMA) were determined using stereotaxic coordinates from MR images of the monkey’s brain using a 3.0 T MR imaging (MRI) system (Philips Ingenia 3.0 T, Philips Healthcare, Best, The Netherlands). The anatomical MRI protocols consisted of a T1-weighted turbo field echo sequence (repetition time/echo time, 7.3/3.2 ms; number of excitations, 2; flip angle, 8°; field of view, 134 × 134 mm; matrix, 224 × 224; slice thickness, 0.6 mm; number of slices, 200). Pentobarbital anesthesia was administered at 20 mg/kg, after which the parietal region of scalp was incised and optode sockets were formed on the skull surface with self-curing acrylic resin (UNIFAST II Clear, GC Corporation, Tokyo, Japan). Titanium oxide (KA-30, Titan Kogyo, Ltd., Ube, Japan) was mixed into the resin at a weight ratio of 1:450 to match its optical scattering property to that of the skull. These procedures were done under sterile conditions.
7
Multiparametric MRI Protocol for Comprehensive Evaluation
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MRI was performed using the 3.0-T Ingenia or 3.0-T Ingenia CX MR system (Philips Healthcare, Best, the Netherlands) with an abdominal eight-channel surface phased array coil. The main sequences included sagittal T2-weighted imaging (T2WI), axial T2WI, coronal T2WI, axial T1-weighted imaging (T1WI), diffusion-weighted imaging (DWI) (b values of 0, 1000, and 2000 s/mm2), Apparent diffusion coefficient (ADC) maps, and dynamic contrast-enhanced (DCE)-MRI. Gadopentetate dimeglumine (Omniscan, GE Healthcare, Milwaukee, WI; Magnevist; Bayer Healthcare) was intravenously injected at a dose of 0.1 mmol/kg of body weight and rate of 2.5 mL/s by using an automatic injector (Guerbet). The details of MRI acquisition parameters, including the sequence, flip angle (degree), repetition time (TR)/echo time (TE), echo train length, matrix size, field of view, thickness, and b values, are summarized in Supplementary Materials (Table S1 ).
8
Multimodal MRI Acquisition Protocol for Brain Imaging
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All MRI scans were acquired using 3.0-T scanner [Achieva 3.0 T TX (eight-channel head coil) or 3.0 T Ingenia (32-channel head coil), Philips, Eindhoven, Netherlands] at Nanjing Drum Tower Hospital. Subjects were placed in the supine position. Sagittal T1-weighted MR images were performed by a three-dimensional turbo fast echo acquisition with the following parameters: repetition time (TR) = 9.8 ms, echo time (TE) = 4.6 ms, inversion time (TI) = 900 ms, flip angle = 8°, field of view (FOV) = 256 × 256 mm, matrix = 256 × 256, number of slices = 192, and slice thickness = 1 mm. DTI data were obtained using an echo planar imaging (EPI) sequence with the following parameters: in 32 non-collinear directions diffusion encoding (b = 1,000 s/mm2 for each direction) and one image with no diffusion weighting (b = 0 s/mm2), TR = 9,154 ms, TE = 55 ms, flip angle = 90°, matrix size = 112 × 112, FOV = 224 × 224 mm, and slice thickness = 2.5 mm. The total scan lasted 13 min. Additionally, axial T2-weighted, diffusion-weighted imaging (DWI) sequence, and fluid-attenuated inversion recovery (FLAIR) sequence were collected to detect acute or subacute infarctions and visible WM damage.
9
CMR Evaluation of IS and MVO after PCI
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All patients underwent CMR examination within 1 week after PCI using the Philips 3.0T Ingenia magnetic resonance imaging system. The patients were positioned in a supine position, and the breath-holding sequence was scanned over 12 cardiac cycles with a breath-holding time of 12-17 s. Gadolinium was then administered via a peripheral vein for first-pass perfusion scans, and myocardial delayed gradient echo inversion recovery sequence enhancement scans were performed 10 min after injection (TR: 6 ms, TE: 3 ms, FA: 25°, TI: 260-350 ms, shot duration: 100-125 ms, voxel: 1.6 mm × 1.9 mm × 8 mm). CMR images were analyzed by experienced radiologists. The area of IS was shown as hyperintensity in images, and MVO was described as hypointense areas in the area of IS in late-gadolinium enhancement (LGE) CMR images. The representative CMR-LGE images are shown in Supplementary Fig. 1. Both IS and MVO were expressed as their percentage of left ventricle (LV).
10
Pituitary Microadenoma Detection using MRI
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This retrospective case series was approved by the institutional review board of Moriyama Memorial Hospital. We investigated patients who underwent IPSS at our hospital between April 2018 and December 2020. During that period, 65 patients were referred to our hospital for endocrinologically diagnosed CD; all the patients underwent MRI using a 1.5T scanner (1.5T MAGNETOM Aera, Siemens Healthcare, Erlangen, Germany). After a 3.0T MRI (3.0T Ingenia, Philips Healthcare, Best, The Netherlands) system was introduced at Moriyama Memorial Hospital in October 2020, all MRI studies since then were performed with 3.0T MRI. As per routine, coronal and sagittal sections were obtained using nonenhanced T1-weighted spin echo (SE), T2-weighted SE, and enhanced T1-weighted SE sequences. All patients with microadenomas or tumors that were invisible on MRI were also imaged using a 3Dspoiled gradient echo sequence. The minimum size of detectable pituitary lesions by the MRI scans used in this study was approximately 2 mm. Even with meticulous analysis of the MRI results, no definite adenomas were apparent in 19 patients. Among them, 14 patients underwent 1.5T MRI and five underwent 3.0T MRI following the aforementioned method. All patients underwent IPSS after receiving a detailed explanation of the procedure, following which informed consent was obtained.
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